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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A Better Start Evaluation - A Better Start Impact and Economic Evaluation ProgrammeIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 A feasibility study of early and enhanced rehabilitation in ICU - A feasibility study of early and enhanced rehabilitation in critical care and potential impact on immunoendocrine functionIn Set-Up Pending NHS PermissionInterventionalNo
 A feasibility study of treatments for Dupuytren's Contracture - Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers: a feasibility study which investigates the acceptability and design of a multicentre randomised controlled trial (RCT).In Set-Up Pending NHS PermissionObservationalNo
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A study of the effectiveness of different kinds of hip replacements - RSA-measured in vivo migration and micromotion in the DePuy TriLock, Corail and Deltamotion hip replacement components: a singleblinded randomised control trial.In Set-Up Pending NHS Permissionnot specifiedNo
 A study on maternity service user’s contribution to safety - Speaking Up, Listening and Responding; an exploration of factors affecting women speaking up about the safety of their health in maternity careIn Set-Up Pending NHS PermissionObservationalNo
 ABC-07 - Addition of stereotactic body radiotherapy to systemic chemotherapy in locally advanced biliary tract cancersIn Set-Up Pending NHS Permission  
 ACELARATE - A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC1031) with Gemcitabine in patient with metastatic pancreatic carcinoma. (ACELARATE)In Set-Up Pending NHS PermissionInterventional 
 ACTICCA-­1 - Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA­-1 trial) A randomized, multidisciplinary, multinational AIO/DGAV/DGVS phase III trial.In Set-Up Pending NHS PermissionInterventional 
 ADDITION Plus - 10 year - ADDITION Plus - 10 year   
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Advanced OCT and Adaptive Optics Imaging in Retinal Disease - A Prospective Study to Evaluate Swept-Source OCT and Adaptive Optics Imaging of Diseases of the Vitreous, Retina and ChoroidIn Set-Up Pending NHS PermissionObservationalNo
 ALSCarE - A Programme for ALS Care in Europe (ALSCarE)In Set-Up Pending NHS PermissionObservational 
 AMPSIM - A pilot study to compare Virtual Reality (VR) versus VR plus haptic feedback as a possible technique to decrease phantom pain responses in amputeesIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Antiplatelet therapy in COPD (APPLE-COPD:ICON 2) - Anti-platelet Therapy in the Primary Prevention of Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease.In Set-Up Pending NHS PermissionObservationalNo
 ASSESSING STATUS OF VISUAL CORTEX IN PATIENTS WITH MACULAR DISEASE 1.0 - ASSESSING STATUS OF VISUAL CORTEX IN PATIENTS WITH MACULAR DISEASE 1.0In Set-Up Pending NHS PermissionObservationalNo
 AXAFA – AFNET 5 - Anticoagulation using the direct factor Xa inhibitor apixaban during Atrial Fibrillation catheter Ablation: Comparison to vitamin K antagonist therapy. A32. National coordinating investigator   
 Baby Express Research Trial - First Year Together: Evaluation of Baby Express in Greater ManchesterIn Set-Up Pending NHS PermissionObservationalNo
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Breath Analysis in ICU for Diagnosis of Ventilator Associated Pneumonia - Breath Analysis in Intensive Care: Proof of Concept for Non-Invasive Diagnosis of Ventilator Associated PneumoniaIn Set-Up Pending NHS PermissionObservationalNo
 Calibre - CALiBRe: Assessment of the Mechanism of Action of idelalisi (CAL101) in B-cell Receptor Pathway Inhibition in CLLIn Set-Up Pending NHS Permission  
 CAM­-PLEX - To assess the safety of continuous IV administration of the CXCR4  antagonist, plerixafor (Mozobil), at potentially active plasma concentrations and assess its impact on the immune  microenvironment in patients with advanced pancreatic, high grade  serous ovarian and colorectal adenocarcinomasIn Set-Up Pending NHS PermissionInterventional 
 CapaCiTY Study 2 - Chronic Constipation Treatment Pathway - PRAGMATIC RANDOMISED TRIAL OF LOW VERSUS HIGH VOLUME INITIATED TRANSANAL IRRIGATION THERAPY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventionalNo
 CapaCiTY Study 3-Chronic Cinstipation Treatment Pathway - STEPPED WEDGE RANDOMISED TRIAL OF LAPAROSCOPIC VENTRAL MESH RECTOPEXY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Cerebral Visual Disorders Classification System - Development and validation of a new classification system and assessment protocol for children with cerebral visual disordersIn Set-Up Pending NHS PermissionInterventional 
 Chronic neuroinflammation following blast TBI - Investigating chronic neuroinflammation and neurodegeneration following blast traumatic brain injury (bTBI) and its relationship to brain structure and functionIn Set-Up NHS Permission ReceivedObservational 
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Clinically isolated syndrome 30 year follow up study - Clinically isolated syndromes and multiple sclerosis: prospective clinical and MRI follow up after 30 years and features at earlier time-points.In Set-Up Pending NHS PermissionObservationalNo
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Cognitive Dysfunction in Coeliac Disease - A Study of Cognitive Dysfunction in Coeliac Disease and the Impact of Good Adherence to a Gluten Free DietIn Set-Up Pending NHS PermissionObservationalNo
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 CTC tumourgenicity in early stage NSCLC - Tumourigenicity of Circulating Tumour Cells in Early Stage Lung Cancer to Predict Disease RecurrenceIn Set-Up Pending NHS PermissionObservationalNo
 DECIDE and SHARE-IT: shared decision making - Development of generic decision aids linked to recommendations in GRADE guidelines to promote shared decision making in the clinical encounter: user-testing and feedbackIn Set-Up Pending NHS Permission  
 Deep brain stimulation for bladder control - Deep brain stimulation for bladder controlIn Set-Up Pending NHS PermissionObservationalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing the compassion towards others scale (CTOS) - Developing a measure of compassion towards others and examining the roles of self-compassion and other-compassion as mechanisms of mindfulnessIn Set-Up Pending NHS PermissionObservationalNo
 Development of a lifestyle service pathway in NAFLD - Development of the first evidence based lifestyle service pathway for people with non-alcoholic fatty liver disease (NAFLD) Phase 1: Exploring the current service pathwayIn Set-Up Pending NHS PermissionObservationalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Dex - CSDH Trial - A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematomaIn Set-Up Pending NHS PermissionInterventionalNo
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diagnosing and monitoring infection in critical illness - Diagnosing and monitoring infection in critically ill patients using metabolic and immunological signaturesIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early Diagnosis of Inherited Immune Deficiency - Bringing Next Generation Sequencing to the Next Generation: Early Diagnosis of Inherited Immune DeficiencyIn Set-Up Pending NHS PermissionInterventional 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effects of AZD7325 on cutaneous sensation - A phase I single site, single dose, randomized, double-blind, placebo controlled, 3-way cross-over biomarker study investigating the effect of the GABA modulator AZD7325 on cutaneous sensation in healthy volunteersIn Set-Up Pending NHS PermissionInterventionalNo
 E-FIT 1 v1.0 - A multi-centre, randomised, double blind, placebo-controlled trial evaluating the effects of early administration of fibrinogen concentrate in adults with major traumatic haemorrhage. E-FIT 1 StudyIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 EHOD and Cystadane Surveillance protocol - European Network and Registry for Homocystinurias and Methylation Defects (EHOD) And Cystadane® SurveillanceIn Set-Up Pending NHS PermissionObservational 
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 ERUK - ERUK - Established and novel cell-surface autoantibodies in adults with new-onset cryptogenic epilepsiesOpenObservationalNo
 Evaluation of nonlinear propagation artifact correction - Evaluation of nonlinear propagation artifact correctionIn Set-Up Pending NHS Permission  
 Extending Working Lives in the NHS version 1Extending Working Lives in the NHS version 1 - Extending Working Lives in the NHS: Opportunities, Challenges and ProspectsIn Set-Up Pending NHS Permission  
 Faecal Microflora in ITP vs1 - Is Immune thrombocytopaenic purpura (ITP) associated with an abnormal faecal microflora?In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Fluciclovine (18F) PET/CT in biochemical recurrence of prostate cancer - A phase 3 open label study to assess the clinical utility of Fluciclovine (18F) PET/CT in patients with prostate cancer with biochemical recurrence after radical treatmentIn Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 GARMIN-II: double-blind randomised controlled trial of lesogaberan in cough - The Role of GABAb receptor mechanisms in cough: Double-blind randomised controlled trial of Lesogaberan in Chronic cough patients with positive and negative symptom association probabilitiesIn Set-Up Pending NHS PermissionInterventionalNo
 Generation of iPS Cells and Rare Diseases - Generation of Induced Pluripotent Stem (iPS) Cells and Rare DiseasesIn Set-Up Pending NHS Permissionnot specifiedNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GOLMePsA - An investigator-initiated double-blind, parallel-group randomised controlled trial of GOLimumab and Methotrexate versus Methotrexate in very early PsA using clinical and whole body MRI outcomes: the GOLMePsA study.In Set-Up Pending NHS Permissionnot specifiedNo
 GRAD - Can genomics predict dysphagia after head and neck radiotherapy? - v1In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 GTPS: does shockwave therapy help? - Does Focused Extracorporeal Shock Wave Therapy Improve Greater Trochanteric Pain Syndrome Compared to an Ultrasound Guided Steroid Injection?In Set-Up Pending NHS PermissionObservationalNo
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 IPS for patients with offending histories (IPSOH) - Individual Placement and Support (IPS) for patients with offending histories: Feasibility of an evidence-based approach in forensic mental health settingsIn Set-Up Pending NHS PermissionInterventionalNo
 Kidney Injury after Major Surgery (KIMS) - Observational study of the long term outcomes of acute kidney injury after major surgeryIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 LAIV and EHPC - The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage StudyIn Set-Up Pending NHS PermissionObservationalNo
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 LONG LIMB - Are gut hormone changes why the longlimb gastric bypass is more effective than the standard limb gastric bypass in improving type 2 diabetes mellitus?   
 Long term abdominal drains in end stage cirrhosis - Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis : a feasibility randomised controlled trial.In Set-Up Pending NHS PermissionObservationalNo
 LOPAC Laser Ablation versus Observation to Prevent Anal Cancer v.1.0 - A randomised controlled trial to study the effectiveness of Laser Ablation versus Observation to Prevent Anal Cancer in men who have sex with men with human immunodeficiency virus infection who have high­grade anal intraepithelial neoplasia (AIN 2 and/or AIN 3) disease (The LOPAC Trial)In Set-Up Pending NHS Permission  
 LOTUS Study - Dynamic Lycra Orthoses as an adjunct to upper limb rehabilitation after stroke: A feasibility study and trial.In Set-Up Pending NHS PermissionInterventionalNo
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Metabolomics in SLE - Pilot study on the use of metabolomics to predict outcome in patients with systemic lupus erythematosusIn Set-Up Pending NHS PermissionObservationalNo
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MILESTONE-Transitions - The MILESTONE Study: Improving Transition from Child to Adult Mental Health CareIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 MISSION - MISSION Severe Asthma: Modern Innovative Solutions to Improve Outcomes in Severe Asthma. A mixed methods observational comparison of clinical outcomes in MISSION versus current care delivery.In Set-Up Pending NHS PermissionObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Multimodality imaging of the aorta - Investigation into aortic structure and function using magnetic resonance imaging (MRI), computed tomography (CT) and position emission tomography (PET)In Set-Up Pending NHS Permission  
 NMDA PET in TBI - Imaging NMDA receptor activation following head injury using positron emission tomographyIn Set-Up Pending NHS PermissionObservationalNo
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke SurvivorsIn Set-Up Pending NHS Permission  
 Ob-AKI feasibility study - The impact of obesity on recovery from acute kidney injury (AKI): the Ob-AKI feasibility studyIn Set-Up Pending NHS Permission  
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patients' views of discussing weight management with knee OA V1.15.1.15 - To understand patients’ views and experiences of discussing weight management with a health professional when they have a clinical diagnosis of knee osteoarthritis and a BMI of over 25.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 Precise study social science programme - Developing patient centred, rapid, Point of Care testing including antimicrobial resistance markers for specialist sexual health services in the NHS: the Precise study social science programme.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 PredictCAT v1.1 - Predicting Self-Reported Benefit, Supporting Decision Making and Calibrating Health Utilities for Cataract Surgery. Part of a NIHR Grant Funded Programme for Applied Research. Cataract Surgery: Measuring and Predicting Patient Level Vision Related Health Benefits and Harms.In Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predicting poor outcome following total hip and knee arthroplasty - A prospective observational (C) study in adult patients with primary osteoarthritis (P), to identify the physical and psychological risk factors predicting poor patient satisfaction and function (O) following primary total hip and knee arthroplasty (I)       I ­ Intervention       P ­ Population       O ­ Outcome       C ­ ComparatorIn Set-Up Pending NHS PermissionObservationalNo
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Pre-Operative JX-594 - A clinical study to evaluate the biological effects of pre-operative intravenous administration of JX-594 (thymidine kinase-deactivated Vaccinia virus plus GM-CSF) prior to planned surgical resection of locally advanced/poor prognosis or metastatic cancersIn Set-Up Pending NHS Permission  
 Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 PRIM4641 - A method validation, single-period, open-label evaluation study to explore the sensitivity of a novel biosensor device (SenseWear® Armband Gecko) for measuring physical activity in subjects with COPD & AsthmaIn Set-Up Pending NHS Permission  
 Protein defects in retinal degenerations (version 0.9) - Investigation of protein defects in inherited retinal degenerationsIn Set-Up Pending NHS PermissionObservationalNo
 Provision Of Psychological support to People in Intensive care (v1.0) - Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI) cluster-randomised controlled trialIn Set-Up NHS Permission ReceivedInterventionalNo
 Psoriasis and emotional response following treatment (PsERT) - Psoriasis and emotional response following treatment (PsERT) - A functional magnetic resonance imaging studyIn Set-Up Pending NHS PermissionObservationalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 RAIDER - A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladderIn Set-Up Pending NHS PermissionInterventional 
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Rare Diseases Translational Research- DMD - Neuromuscular Rare Disease Translational Research in patients with Duchenne Muscular DystrophyIn Set-Up Pending NHS PermissionInterventional 
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?   
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Repurposing anti-TNF for treating Dupuytren's disease - A multicentre, double blind, randomised, placebocontrolled, parallel group, phase II trial to determine the safety and efficacy of intranodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with a dose response run-in.In Set-Up Pending NHS PermissionObservationalNo
 RESCUE-COPD1 Version 1 - Randomised trial of E-Health platform Supported Care vs Usual care after Exacerbation of COPDIn Set-Up Pending NHS Permissionnot specifiedNo
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Rowing Away from Diabetes - Indoor rowing in adults with impaired glucose regulation: a pilot study   
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 SCIMITAR Plus (version 1.0) - Smoking Cessation Intervention for Severe Mental Ill Health Trial (SCIMITAR): a definitive randomised evaluation of a bespoke smoking cessation serviceIn Set-Up Pending NHS Permission  
 Shed tumour cells in bladder cancer - Feasibility study for the detection of shed urothelial tumour cells in the urine of bladder and upper urothelial tract cancer patients for monitoring and diagnosisIn Set-Up Pending NHS Permission  
 ShoulderLink - Acceptability of real time 1:1 videoconferencing consultations after shoulder rehabilitationIn Set-Up Pending NHS PermissionObservationalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Simvastatin in sight threatening Uveitis trial (SU) - Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial.In Set-Up Pending NHS PermissionInterventionalNo
 SINAPPS One - An unblinded study of the feasibility of plasmapheresis or intravenous immunoglobulin, combined with corticosteroids, in patients with acute psychosis associated with anti-neuronal membrane auto-antibodies.In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
12726986SPRAINED Study - Synthesising a clinical Prognostic Rule for Ankle Injuries in the Emergency Department (SPRAINED)In Set-Up NHS Permission ReceivedObservationalYes, within lead country only
 Structural brain abnormalities and hypoxia in sickle cell anaemia - Structural brain abnormalities and hypoxia in sickle cell anaemiaIn Set-Up Pending NHS PermissionInterventional 
 Study of the effects of Vitamin D on immune responses to Tuberculosis - Study of the effects of Vitamin D on immune responses to Tuberculosis.In Set-Up Pending NHS Permissionnot specifiedNo
 Supporting physiotherapy adherence in children with cystic fibrosis - Development of an intervention to increase physiotherapy adherence among young children with cystic fibrosis: a Medical Research Council complex intervention framework development and feasibility study   
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 The consequences of motor unit remodelling for motor control - The consequences of motor unit remodelling for motor control: an important factor in the loss of mobility with old age.   
 The E-SEE trial v1 - Enhancing Social-Emotional Health and Wellbeing in the Early Years: A Community-based Randomised Controlled Trial (and Economic) Evaluation of the Incredible Years Infant and Toddler (0-2) Parenting ProgrammesIn Set-Up Pending NHS Permission  
 The INFECIR2 Albumin Prevention Study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.In Set-Up Pending NHS PermissionObservationalNo
 The PRACTICE Trial - Pulmonary Rehabilitation and ACTIvity after COPD Exacerbation - The PRACTICE TrialIn Set-Up Pending NHS PermissionObservationalNo
 The role of LLT1 in immune evasion and hepatocellular carcinoma - The role of LLT1 in immune evasion and hepatocellular carcinomaIn Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 Transitions from paediatric to adult services for sickle cell disease - Transitions from paediatric to adult services for sickle cell disease (SCD): a prospective qualitative study examining young adult patients’ experiencesIn Set-Up Pending NHS PermissionObservationalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Users' and carers' views of stratified medicine: phase 2 - Mental Health Service Users' and Carers' Views of Stratified Medicine for Treatment Resistant Schizophrenia: Phase 2In Set-Up Pending NHS PermissionObservationalNo
 Vaccines Against Salmonella Typhi (VAST) - Vaccines Against Salmonella Typhi: a phase IIb, single centre, observerblind, randomised controlled trial to assess the immunogenicity and protective efficacy of Vi conjugated (ViTCV) and unconjugated (ViPS) polysaccharide vaccines in preventing typhoid infection compared to a control vaccine (meningococcal ACWY), using a human challenge model of typhoid infectionIn Set-Up Pending NHS PermissionObservationalNo
 Validating the MSKHQ - Validating the Arthritis Research UK Musculoskeletal Health Questionnaire (MSKHQ).In Set-Up Pending NHS PermissionObservationalNo
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vibrant Effectiveness and Reliability Study (VERS) - Evaluating the long-term reliability and performance of the Vibrant Soundbridge and Bonebridge systemsIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Vision On: HAI training tool - Vision-on: Staff Training Tool for the Prevention of Healthcare Associated InfectionsOpenObservationalNo
 VOLUME 6 - An Exploratory Randomised Controlled Trial Assessing Volunteering in Mental Health Care for People with PsychosisIn Set-Up Pending NHS PermissionInterventionalNo
 WATCH Wessex Asthma Lifetime Cohort study - WATCH - Wessex Asthma Lifetime Cohort studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 WB-DW-MRI at 3T in relapsed multiple myeloma:early response assessment - Pilot study to evaluate diffusion-weighted MRI (DWMRI) Whole Body MRI in relapsed Multiple Myeloma at 3T: test-retest, early response assessment and exploratory imaging of renal function.In Set-Up Pending NHS PermissionInterventional 
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 WREN Study - A WebBased Cardiac REhabilitatioN Alternative for Those Declining or Dropping Out Of Conventional Rehabilitation: The WREN Feasibility Study   




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