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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
  genetic testing preventative biphosphonate treatment Pagets disease - MRC GaP Study Stage 1 - Interview Study investigating the acceptability of genetic testing followed by preventative biphosphonate treatment for Paget's disease of bone    
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A patient reported outcome measure for polymyalgia rheumatica - Design of a patient reported outcome measure for polymyalgia rheumaticaIn Set-Up Pending NHS Permission  
 A Phase I Study to Assess Two New Influenza Vaccine Candidates - A Phase I Study to Determine the Safety and Immunogenicity of Vaccination Regimens Employing the Candidate Influenza Vaccines MVA-NP+M1 and ChAdOx1 NP+M1In Set-Up Pending NHS PermissionInterventionalNo
 A Phase I trial of AZD2014 in combination with paclitaxel - TAX TORC - TAXTORC: A Phase I multi-centre trial of the combination of AZD2014 (dual TORC1 and TORC2 inhibitor) and weekly paclitaxel in patients with solid tumoursIn Set-Up Pending NHS PermissionInterventional 
 A qualitative evaluation of care planning in primary care - A qualitative observation and interview study exploring the process and outcome of care planning for people with longterm conditions in primary careIn Set-Up Pending NHS Permission  
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 A study of serological markers for Cryptosporidium exposure and variation over time associated - A study of serological markers for Cryptosporidium exposure and variation over time associated with changes in the treatment of drinking water.OpenObservational-unknown-
 A Trial of Nilvadipine in Mild to Moderate Alzheimer's disease - A European multicenre double-blind placebo controlled phase III trial of nilvadipine in mild to moderate Alzheimer's disease.In Set-Up Pending NHS PermissionInterventionalNo
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Acanthamoeba Keratitis Study - Retrospective and prospective case control study of contact lens wearers investigating the genetic and environmental risk factors for the susceptibility and severity of Acanthamoeba keratitis and further complicationsOpenObservationalNo
 ACES Art as Creative Engagement for Stroke - Can an arts based creative engagement intervention following stroke improve psychosocial outcomes? A feasibility trial of a creative engagement intervention for in-patient rehabilitation   
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 AKT inhibitor in breast cancer (STAKT study) - The short term effects of an AKT inhibitor (AZD5363) on biomarkers of the AKT pathway and antitumour activity in a breast cancer paired biopsy study (STAKT Trial)In Set-Up Pending NHS Permission  
 Alemtuzumab and Rheumatoid Arthritis - An Immunisation Study - Alemtuzumab and Rheumatoid Arthritis - An Immunisation StudyIn Set-Up Pending NHS PermissionObservationalNo
 Amygdala neural responses in depression and bipolar disorder - Evaluation of Amygdala neural responses as a putative distinctive biomarker for bipolar disorder vs. unipolar depression (BUD study: Bipolar vs. Unipolar Depression)In Set-Up Pending NHS PermissionInterventional and ObservationalNo
 An evaluation of the RCAS course - An evaluation of the RCAS courseIn Set-Up Pending NHS Permission  
 Anti inflammatory effects of Keratinocyte growth factor in acute lung injury - Anti inflammatory effects of keratinocyte growth factor in acute lung injury in healthy volunteers   
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Anticipated regret to increase colorectal cancer screening - A randomised controlled trial of a brief psychological intervention to increase the uptake of colorectal cancer screening in ScotlandIn Set-Up Pending NHS PermissionObservationalNo
 Aspects Musculoskeletal Health - The Hertfordshire Cohort Study: Aspects of Musculoskeletal HealthClosed N/A
 ASSertID Phase 2 - A Pilot Randomised Controlled Trial of Drug Treatment for Depression in Patients undergoing HaemodialysisIn Set-Up NHS Permission ReceivedInterventionalNo
 ASSertID Phase 3 - Drug Treatment for Depression in Patients undergoing Haemodialysis Qualitative StudyIn Set-Up NHS Permission ReceivedObservational-unknown-
 Assessment SLE - Validation of BILAG2004 index for assessment of disease activity in systemic lupus erythematosus (SLE)    
 Asthma goals feasibility study - Can eliciting and addressing health-related goals improve asthma control and asthma-related quality of life? Feasibility Phase II pilot randomised controlled trial of a brief interventionIn Set-Up Pending NHS PermissionInterventionalNo
 ASTROLAB - Assessment of the safety of Long Acting Beta Agonists (LABAs) in Asthma in Routine Care by combining healthcare databases and direct patient follow upIn Set-Up Pending NHS Permission  
 ATesting01 - TESTING   
 ATTILA - Assistive Technology and Telecare to Maintain Independent Living At Home for People with DementiaIn Set-Up Pending NHS PermissionInterventionalNo
 Avoidance in OCD - An investigation of the neural correlates of active avoidance in obsessive compulsive disorderIn Set-Up Pending NHS PermissionInterventionalNo
 BARACK D - Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) Trial: a prospective randomised open blinded endpoint trial to determine the effect of aldosterone receptor antagonism on mortality and cardiovascular outcomes in patients with stage 3b chronic kidney disease.In Set-Up Pending NHS Permission  
 Beliefs and Psychosis: Diary Study - Beliefs and Psychosis: Diary StudyIn Set-Up Pending NHS PermissionObservational-unknown-
 Beliefs and Psychosis: Interview Study - Beliefs and Psychosis: Interview StudyIn Set-Up Pending NHS PermissionObservationalNo
 BELLS - Bell's palsy: Early acicLovir and/or prednisoLone in ScotlandOpenInterventional-unknown-
 bilateral versus single IMA - A randomised trial to compare survival following bilateral versus single internal mammary (IMA) grafting in coronary revascularisation    
 BLIS - Barriers to life style interventions in schizophrenia   
 Blood Pressure Self-Screening in Oxfordshire - Blood Pressure SelfScreening in Oxfordshire: A Survey of Sites and Interviews with Current and Potential Service Users and ProvidersIn Set-Up Pending NHS Permission  
52480460CAPP (Ct Assessment of Pain and Plaque) - Cardiac CT for the Assessment of Chest Pain and PlaqueOpenInterventionalNo
 Cartilage disease - Cartilage repair by autologous chondrocyte transplantation (ACTIVE)   
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Causal Modelling of Mobility Disability. - Mobility disability in joint replacement patients: testing a causal theoretical model using an n-of-1 design.ClosedObservationalN/A
 Causality expectations treatment chronic musculoskeletal pain - Pain clinic practitioners' beliefs about the causality of, and expectations for treatment of chronic musculoskeletal pain   -unknown-
 Changes body composition through puberty - Lifestyle and changes in body composition through puberty: a resource for the study of gene-environment interactions    
 Characterisation microcephalin - Functional and Developmental characterisation of microcephalin, the MCPH1 primary microcephaly gene    
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 CLIC-GCA/PMR - "Clinical and immunogenetic characterization of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) "    
 Clinical immunogenetic characterization GCA PMR - Clinical and immunogenetic characterization of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR)    
 Clinical productivity in community pharmacy 1.0 - Investigating the organisational factors associated with variation in clincal productivity in community pharmaciesIn Set-Up Pending NHS PermissionObservational 
 CoBalT 2 - A long term follow-up of the CoBalT study participantsIn Set-Up Pending NHS PermissionObservationalNo
 COCAPP: Collaborative Care Planning Project - Cross-national comparative study of recovery-focused mental health care planning and coordinationIn Set-Up Pending NHS PermissionObservationalNo
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategies   
 Cognitive behaviour therapy - Scottish Neurological Symptoms Study: Treatment development project.   
 COGS 1 - Genetic susceptibility to colorectal cancer in Scotland: development of a strategy for the delivery of genetic screening an counselling and for targeting cancer prevention modalitiesOpen -unknown-
 Combination chemotherapy of Human African trypanosomiasis - Combination chemotherapy of Human African trypanosomiasis: the potential of drug synergism and the blood-brain barrier   
 Comparing Adults' and Children's Experiences of Trial Recruitment: CACE - Comparing Adults' and Children's Experiences of Recruitment to a Clinical Trial: CACE StudyOpenObservationalNo
 Comparison of dental plaque salivary microflora composition and salivary parameters between caries - Comparison of dental plaque salivary microflora composition and salivary parameters between caries free and caries prone subjects   
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCA - A randomized double-blind, placebo-controlled study of risperidone in the treatment of DSM-IV-TR conduct disorder in children and adolescentsIn Set-Up Pending NHS PermissionInterventionalNo
 Conker: Examining Interactions in Consultations for RTI in Children - Examining the interactions and behaviours in consultations for childhood respiratory tract infections.In Set-Up Pending NHS PermissionObservational 
 COPE-A-LOT-SCOT - COPE-A-LOT-SCOT: Exploring the feasibility of conducting a randomised controlled trial to test the impact of an evidence-based online cognitive-behaviour therapy intervention on child dental anxiety.In Set-Up Pending NHS PermissionObservationalNo
 Cost effectiveness ECP - A multi-centre community intervention trial to evaluate the clinical cost effectiveness of Emergency Care Practitioners    
 CRACT - MRC funded trial: Cartilage Repair by Autologous Chondrocyte Transplantation    
 CREATE (EORTC 90101) - Cross-tumoral Phase 2 clinical trial exploring Crizotinib (PF02341066) in patients with advanced tumours induced by causal alterations of either ALK or MET.In Set-Up Pending NHS PermissionInterventional 
63510637CRIB: Cardiac rehabilitation for colorectal cancer patients - The use of cardiac rehabilitation services to aid the recovery of colorectal cancer patients: A pilot randomised controlled trial with embedded feasiblity studyOpenInterventionalNo
 CTL Activity HIV - Cytotoxic T Lymphocyte (CTL) activity in chronic untreated HIV infection    
 CTL-HIV - Cytotoxic T Lymphocyte (CTL) activity in chronic untreated HIV infection    
 Dental therapists carrying out National Dental Inspection Programme - A cross-sectional evaluation study of inter-rater agreement, evaluating the ability of dental therapists to carry out dental inspections   
 DESTINY - DESTINY (DeEscalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in chronic myeloid leukaemia)In Set-Up Pending NHS Permission  
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Detection and management of pain in patients with dementia - The detection and management of pain in patients with dementia in acute care settings: Development of a Decision Support ToolIn Set-Up Pending NHS PermissionObservationalNo
 Developing measures of empathy and reasoning - Developing measures and exploring relationships between empathy, reasoning and problem solving with men with intellectual disabilities who have forensic mental health problemsIn Set-Up Pending NHS PermissionObservationalNo
 Developing the PRASE Intervention: A Multi-centred Evaluation - Developing the PRASE Intervention: A Multi-centred EvaluationOpenInterventionalYes, within lead country only
 Development of a tumour radiosensitivity-associated - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinants ObservationalNo
 Diabetes 005 (LRN East) - Epidemiological contribution to the primary prevention and early detection of Type 2 diabetes ObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivity   
 Diabetes research on patient sTratification (DIRECT): GLP-1 assay validation study. - Diabetes research on patient sTratification (DIRECT): GLP-1 assay validation study.   
 DIKPRO Trial - A randomised controlled trial of different knee prostheses    
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 DNA Glomerulonephritis - National DNA Bank for Glomerulonephritis    
 DRN 787 (CRAFT study) - Community based programme to Reduce diabetes risk in Asians using Faith centre Testing (CRAFT Study)In Set-Up Pending NHS Permission  
 DRN 802 Glucoescence - A pilot study to test a non-invasive glucose monitoring device   
 DRN 812 Kisspeptin in pregnancy and gestational diabetes - Plasma kisspeptin in pregnancy and gestational diabetes: a translational studyIn Set-Up Pending NHS Permission  
 DRN 813 ACUTE study - Does breaking sedentary time improve glucose regulation in women with impaired glucose tolerance? A Balanced Incomplete Block Design Study: ACUTE StudyIn Set-Up Pending NHS PermissionObservationalNo
 DRN 814 Diabetes Intervention for Agenda Trial (DIAT) - A pilot randomised controlled study of the efficacy of a patient-orientated agenda (produced by the PACE-D tool) for use in a diabetes clinical consultation.In Set-Up Pending NHS Permission  
 DRN 819 Leucopatch II - Leucopatch in the management of hard to heal diabetic foot ulcersIn Set-Up Pending NHS Permission  
 DRN 821 Individual risk based screening for diabetic retinopathy: WS B, C, D - Introducing personalised risk-based intervals in screening for diabetic retinopathy: development, implementation and assessment of safety, cost-effectiveness and patient experience. Workstreams B, C and D: Data linkage, risk modelling, observational cohort study and economic modellingIn Set-Up Pending NHS Permission  
 Drug prescribing among pregnant women in Tayside, Scotland: an overview. - Drug prescribing among pregnant women in Tayside, Scotland: an overview.ClosedObservationalN/A
 Early predictor of violence - Early predictor of violenceOpenObservational 
 Early Warning Systems - A realistic evaluation of Early Warning Systems and acute care training for early detection and management of deteriorating ward –based patientsOpenObservationalNo
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 ED CKD - Does sodium cause endothelial dysfunction in patients with chronic kidney disease (CKD)? A pilot study   
 EFFAPRON - The Systemic and renal Effects of Endothelin receptor Antagonism in Proteinuric Nephropathy Interventional-unknown-
 Effect Bisphosphonates Ankylosing Spondylitis - The Effect of Bisphosphonates on Disease Activity and Bone Status in Ankylosing Spondylitis    
 Effect of cardiac and aortic valve pathology on aortic spiral flow. - Effect of cardiac and aortic valve pathology on the prevalence of spiral blood flow within the thoracic aorta.   
 Effect of Remote Ischaemic preConditioning on CIN - A single centre double-blinded randomised placebo controlled study investigating the Effect of Remote Ischaemic preConditioning on Contrast medium Induced Nephropathy in at-risk patients undergoing coronary angiography or PCI. (ERICCIN)In Set-Up Pending NHS PermissionInterventionalNo
 Effect of Sulforaphane on prostate CAncer PrEvention (ESCAPE) - A human dietary intervention study to investigate the effect of sulforaphane on prostate cancer interceptionIn Set-Up Pending NHS PermissionInterventional 
 Effects of high dose UVA1 phototherapy on cutaneous fibrosis and endothelial cell function in patien - Effects of high dose UVA1 phototherapy on cutaneous fibrosis and endothelial cell function in patients with systemic sclerosis.Closed N/A
 Effects Patient - Centred Asthma Education - Effects of Patient - Centred Asthma Education for GPs and Practice Nurses: Evaluating the Impact of Training in Self Regulation Skills on Patient Outcomes: a Randomised Controlled Trial    
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 EQUIP: Training to promote service user involvement in care planning 1 - EQUIP: Training to promote service user involvement in care planning (Focus Groups)In Set-Up NHS Permission ReceivedObservationalNo
 EQUIP: Training to promote service user involvement in care planning 2 - EQUIP: Training to promote service user involvement in care planning 2 (Interview study)In Set-Up Pending NHS PermissionObservationalNo
 Eradicate HCV. - Eradicate Hepatitis C Virus - a pilot of treatment as prevention in active drug users (ERADICATE HCV).   
 EU-TrigTreat Non-Invasive Study - Arrhythmia Risk Stratification in a Clinical Patient Cohort and Correlation with Genotype and Environmental ModulatorsIn Set-Up NHS Permission ReceivedObservational 
 Evaluating the implementation of HeLP-Diabetes - A study to evaluate the implementation of an online self-management programme (HeLPDiabetes) for people with type 2 diabetes within NHS services.In Set-Up Pending NHS Permission  
 Evaluation of dried blood spot and near patient testing for BBVs. - Evaluation of the clinical validity of dried blood spot and near patient testing for the diagnosis of hepatitis C and hepatitis B viruses.   
 Evaluation of PBS: a cluster RCT - Clinical and cost effectiveness of staff training in Positive Behaviour Support (PBS) for treating challenging behaviour in people with intellectual disabilityIn Set-Up Pending NHS PermissionInterventionalNo
 Evaluation of the Consultant NMAHP SPDP. - Evaluation of the Consultant Nurses, Midwives and Allied Health Professionals Succession Planning Development PathwayClosednot specifiedN/A
 Examining Sonographer visuospatial perception and psychomotor ability. - Is there a relationship between ultrasound scanning ability and visuospatial perception and psychomotor ability?OpenObservationalNo
 FAB: Family focused treatment for Adolescents with Bipolar Disorder - A feasibility study of a randomised controlled trial of a Family Focused Treatment (FFT-A UK version) in the management of Early Onset Bipolar Disorder (EOBD) (aged under 18 years)In Set-Up Pending NHS PermissionInterventionalNo
 Factors associated with geographic and temporal variation in Campylobacter infection in humans in - Factors associated with geographic and temporal variation in Campylobacter infection in humans in ScotlandOpenObservational-unknown-
 Factors mediating the effects of prison environment on mental health - Factors mediating the effects of prison environment on mental healthOpenObservational 
 Feasibility evaluation of FLT PET in advanced pancreatic cancer - Feasibility evaluation of proliferation and nucleoside transport using FLT PET imaging in advanced pancreatic cancer patients.In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)   
 FIRE - Fungal Infection Risk Evaluation (FIRE)OpenObservational-unknown-
 Follow up HIV infected persons seen since 1996 - Long-term follow up of all HIV infected persons seen since 1996 in seven major UK centres   
 FUGBOD - Functional genomics of bone disease.Open -unknown-
 Functional anatomy of apathy - The functional anatomy of apathy: A functional MRI study in progressive supranuclear palsy and alzheimer's disease   
 Functional characterisation of synaptolagmin-11 in the 3T3-L1 adipocyte - Functional characterisation of synaptolagmin-11 in the 3T3-L1 adipocyte, conditional adipose-specific knockout mouse and human adipocyteOpen -unknown-
 Functional Developmental characterisation microcephalin - Functional and Developmental characterisation of microcephalin, the MCPH1 primary microcephaly gene    
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 GAP Study - GAP Study - Interview study investigating the acceptability of genetic testing followed by preventative bisphosphonate treatment for Paget's disease of bone.    
 GEM (Guided E-learning for Managers) - Pilot study of a randomised trial of a guided E-learning health promotion intervention based on management standards for the improvement of employee well-being and reduction of sickness absenceIn Set-Up Pending NHS PermissionInterventionalNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GIPARC - A genetic investigation into the aetiology of parkinsonism and related conditions    
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 HARP - Hydroxymethylglutaryl-CoA reductase inhibition in Acute lung injury to Reduce Pulmonary oedema and inflammation (HARP)Open  
 HDITSV - Short course, high dose induction therapy compared to standard treatment for systemic vasculitis Interventional-unknown-
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hippocampal changes in early Alzheimer's disease - Hippocampal changes in early Alzheimer's disease: A multimodal Magnetic Resonance StudyIn Set-Up Pending NHS PermissionInterventionalNo
 Hydralazine/Nitrates in Heart Failure - Assessing the Acute Haemodynamic Effects of Hydralazine and Nitrates, singly and in combination, in Patients with Chronic Heart Failure using Novel Non-invasive Sensor TechnologiesIn Set-Up Pending NHS PermissionInterventionalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate   
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Imaging Hypoxia in Head & Neck Cancer - A pilot study - Imaging Hypoxia to Define Radioresistant Disease in Head & Neck CancerIn Set-Up Pending NHS Permission  
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Immunophenotypic and functional analyses of HSPCs - Characterizing the immunophenotypic and functional differences between normal and defective human haematopoietic stem and progenitor cells (HSPCs)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 In Vitro Modelling of Hypoplastic Left Heart Syndrome - In Vitro Modelling of Hypoplastic Left Heart Syndrome using Induced Pluripotent Stem CellsIn Set-Up Pending NHS PermissionObservationalNo
 Induced sputum in children with cystic fibrosis - The contribution of induced sputum sampling to surveillance of lower respiratory tract microbiology in children with Cystic Fibrosis.   
 Informing patient care pathways:can we improve the surgical experience - The surgical experience: Does optimising the patient care pathway improve the outcome and patient experience?In Set-Up Pending NHS Permission  
 INITIATE - Is intravenous iron and darbepoetin more effective than oral iron in reducing blood transfusion requirements for patients undergoing cardiac surgery?OpenInterventionalNo
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 INSENS - Insulin Sensitisation as a Novel Mechanism to Lessen Ischaemic Burden in Overweight, Non - Diabetic Patients with Chronic Stable Angina: A Pilot Study   -unknown-
 Insight and metacognition in neuropsychiatric disorders - Cognitive and neural correlates of insight and metacognition in first episode psychosis and early-stage dementia or mild cognitive impairment, and their relationship with moodIn Set-Up Pending NHS PermissionObservational-unknown-
 INTEREST - Identification of Novel Biomarkers of Intestinal Ischaemia in Infants and ChildrenOpenObservationalYes, within lead country only
 International Cancer Benchmarking Patership Module 3 - International Cancer Benchmarking Patership Module 3: an international investigation into the causes of delay in diagnosis of cancer in primary care: a mixed methods surveyIn Set-Up Pending NHS Permission  
 Intervention to Assist Lay Cancer Carers Provide Physical Care - Development and Evaluation of an Intervention to Assist Lay Carers to Provide Physical Care to Family Members with Cancer at End-of-LifeIn Set-Up NHS Permission ReceivedInterventionalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating Hereditary Cancer Predisposition - IHCAP - Investigating Hereditary Cancer Predisposition - a combined genomics approachIn Set-Up Pending NHS Permission  
 Investigation Myopia - Investigation of the Genetic Basis of Myopia in the 1958 British Birth Cohort    
 Investigation of immune cell behaviour in inflammatory arthritis. - Investigation of misfolded HLA-B27 molecules from patient-isolated leucocytes and dendritic cells as a novel biomarker for inflammatory arthritis.OpenObservationalNo
 Investigation of Movement in People with Hypermobility - An Investigation of Tibial Movement in People with Benign Joint Hypermobility Syndrome. Do They Move Differently?OpenObservational-unknown-
 Investigation of the cause of Hodgkin Lymphoma V1 - Investigation of the cause of Hodgkin Lymphoma V1   
 KANECT - The use of Ketamine as an anaesthetic during electroconvulsive therapy (ECT) for depression: does it improve treatment outcome?OpenInterventionalNo
98813295KGF - Keratinocyte growth factor (KGF) in an endotoxemic model of acute lung injury in healthy volunteersClosedInterventionalN/A
 Linking cytogenetic abnormalities to p53 mutation and clinical outcome in breast cancer. - Linking cytogenetic abnormalities to p53 mutation and clinical outcome in breast cancer.ClosedObservationalN/A
 LIPOS: Liraglutide in PCOS - Liraglutide in PCOS (LIPOS) Study: Evaluation of the Efficacy of Liraglutide on Menstrual Cyclicity in Women with PCOS - A prospective randomised double-blind placebo-controlled studyIn Set-Up Pending NHS PermissionInterventionalNo
 LOCATE - Local Care and Treatment Evaluation - A community based study to determine the feasibility of remodelling the diagnosis and management of liver disease in primary care to improve patient outcomes and reduce service delivery costs.In Set-Up Pending NHS Permission  
 Longitudinal Study of Corneal Endothelium Cell Density in Glaucoma - Longditudinal Study of Long Term Corneal Endothelial Cell Density Change in Open and Closed Angle Glaucoma PatientsIn Set-Up Pending NHS Permission  
 Long-stay patients in high and medium secure forensic-psychiatric care WP3 - Characteristics and needs of long-stay patients in high and medium secure forensic-psychiatric care: Implications for service organisation WP3 Patient experience of long-stayIn Set-Up Pending NHS PermissionObservationalNo
 Long-stay patients in high and medium secure forensic-psychiatric care WP4 - Characteristics and needs of long-stay patients in high and medium secure forensic-psychiatric care: Implications for service organisation WP4 Service innovationIn Set-Up Pending NHS PermissionObservationalNo
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 Magnetoencephalography (MEG) in Musical Hallucination - Magnetoencephalography (MEG) in Musical HallucinationIn Set-Up Pending NHS PermissionObservationalNo
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Mechanisms and Reversibility of Heart Failure associated with Diabetes - Mechanisms and Reversibility of Heart Failure associated with DiabetesIn Set-Up NHS Permission ReceivedObservationalNo
 Mechanisms underlying treatment resistance in psychosis - Mechanisms underlying treatment resistance in psychosisIn Set-Up Pending NHS PermissionObservationalNo
 Meconium and fatty acid esters - Prevalence of alcohol use during pregnancy: A pilot study measuring meconium fatty acid esters as a surrogate of intra-uterine foetal alcohol exposureOpenObservational-unknown-
 Medication Adherence Post-Stroke - Medication Adherence Post-StrokeIn Set-Up Pending NHS Permission  
 Metabolic Imaging in Carotid Atherosclerosis - An investigation of the role the 18F Sodium Fluoride and 18F Flurodeoxyglucose PET CT and USPIO enhanced MRI in imaging carotid artery inflammation and mineralization   
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
06653773MIR - Mirtazapine added to SSRIs for treatment resistant depression in primary care: a placebo controlled randomised controlled trialIn Set-Up Pending NHS PermissionInterventional 
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Motivational Interviewing for Hearing Aid Use: A Feasibility Study - Application of motivational interviewing in facilitating hearing aid use in hard of hearing individuals who do not use their hearing aids regularly: A feasibility studyIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
 MPD-RC 112 (Pegasys) - Randomized Trial of Pegylated Interferon Alfa-2a versus Hydroxyurea Therapy in the Treatment of High Risk Polycythemia Vera and High Risk Essential ThrombocythemiaIn Set-Up Pending NHS Permission  
 MRI-AAA - Acquisition of time resolved MRI data in abdominal aortic aneurysm.    
 MRS assay of glutamate-GABA in autism - In-vivo MRS assay of brain glutamate-GABA balance and drug response in autism. A pilot case-control studyIn Set-Up Pending NHS PermissionObservationalNo
 Muscle function - Does the oral nutritional supplementation of malnourished older people at hospital discharge improve muscle function? A two centre single blind randomised trial.   
 Musculoskeletal examination children - Development of an evidence based regional musculoskeletal examination for school aged children    
 MUSTEK - A prospective, single-centre, feasibility study evaluating the prevalence of diagnostic clinical imaging features of subclinical enthesitis in patients with moderate to severe plaque psoriasis and the response to skin directed treatment with UstekinumabIn Set-Up NHS Permission ReceivedInterventionalNo
 Neuroinflammation in HIV individuals stable on cART - Neuroinflammation in HIV individuals stable on cART: a [11C] PBR28 PET-CT studyIn Set-Up NHS Permission ReceivedObservationalNo
 Neuronal viability and liver study - Neuronal viability and blood chemistry in liver transplantation   
 NFCSGA - National Family Collection for the Study of the Genetics of Asthma    
 NHS24 Study - Managing Symptoms in the Community: Examining the role of NHS24In Set-Up Pending NHS PermissionObservationalNo
 Novel Detection Methods of Cocaine and its Metabolites - Comparison of Novel Detection Methods of Cocaine and its Metabolites from Varying Biological MatricesOpenInterventionalYes, within lead country only
 OFFSCA-ID - Costs and benefits of social care support for ex-offenders with Learning DisabilitiesIn Set-Up Pending NHS PermissionObservationalNo
 Optimising motor functions and treatment in Parkinson's disease - Development and validation of quantitative methods for assessment of motor functions in Parkinson’s disease and optimisation of treatment.In Set-Up Pending NHS PermissionObservationalNo
 OXTEXT-7: Quantitative evaluation - OXTEXT-7: Stepped wedge cluster randomised controlled trial of Feeling Well with True Colours for community patients in Oxford Health NHS Foundation Trust: quantitative evaluationIn Set-Up Pending NHS PermissionObservationalNo
 OXWATCH - Women and Wellbeing Study - OxWATCH - Oxfordshire Women And Their Children’s HealthIn Set-Up Pending NHS Permission  
 Paediatric European Risperidone Studies - Paediatric European Risperidone StudiesIn Set-Up Pending NHS Permission No
 Pain and Symptom Management in Children - The Symptom Profile and Experience of Children with Rare Life-Limiting Conditions: Perspectives of their Families and Key Health ProfessionalsIn Set-Up Pending NHS Permission  
 Paracrine and endocrine regulation of human luteal granulosa cells, immune cells, fibroblasts and en - Paracrine and endocrine regulation of human luteal granulosa cells, immune cells, fibroblasts and endothelial cells in vitro   
 Partial Left Ventricular Support in Advanced Heart Failure - Partial Left Ventricular Support in Advanced Heart FailureIn Set-Up Pending NHS PermissionObservationalNo
 Patient empowerment using multi-agent systems in the NHS. - Patient empowerment using multi-agent systems in the NHS.ClosedObservationalN/A
 Patients' preferences of general practice services: A pilot study - Patients' preferences of general practice services: A pilot studyIn Set-Up Pending NHS Permission  
 PERAT - Patient education in rheumatoid arthritis: measuring self-efficacy and predicting change    
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Physiotherapy for Hypermobility Trial (PHyT) - The Effects of a Comprehensive Physiotherapy Intervention for Adults with Joint HypermobilityIn Set-Up Pending NHS PermissionInterventionalNo
 Pilot study: impact of gynaecological cancers leaflet in GP practices - Evaluating the impact of a leaflet to raise awareness in women of symptoms of gynaecological cancers on consultation rates, use of diagnostic tests and referrals in primary care. A pilot study in GP practices.In Set-Up Pending NHS PermissionInterventional and ObservationalNo
 Pilot testing: Diabetes and Well-being The two dimension(2D)study - Pilot testing of a Diabetes and Depression (2D) Multi-Component Intervention in preparation for a randomised clinical trialIn Set-Up Pending NHS PermissionInterventionalNo
 PIRFECT - A podiatry intervention to reduce falls in care home residents: development, feasibility and acceptability with exploratory randomised controlled trial   
 PISTUT - PROSPECTIVE COLLABORATIVE STUDY OF PATIENTS WITH INTESTINAL SEGMENTS TRANSPOSED INTO THE URINARY TRACT    
 POETIC: FLT-PET sub-study - Trial of Perioperative Endocrine Therapy - Individualising Care: FLT-PET sub-studyIn Set-Up Pending NHS PermissionInterventional 
 PRAMS - PRAMS: Prediction of Recovery and Monitoring after StrokeIn Set-Up NHS Permission Received  
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting destabilisation: The family's response to alcohol treatment - Predicting destabilisation: The family’s response to alcohol rehabilitation and its impact on treatment outcomesIn Set-Up Pending NHS PermissionObservationalNo
 PrEP - A phase IV study to determine the oral and genital tract concentration of Maraviroc required for ex vivo protection from HIV-1 using Maraviroc 300mg statIn Set-Up Pending NHS PermissionInterventionalNo
 PRESSURE 2 - Pressure Relieving Support Surfaces: A Randomised Evaluation 2In Set-Up Pending NHS Permission Yes, within lead country only
 Primary care consultations, work and musculoskeletal problems - Primary care consultations, work and musculoskeletal problemsIn Set-Up Pending NHS PermissionObservationalNo
 PROCARDIS - Precocious Coronary Artery Disease (PROCARDIS) Study: A family study to identify inherited causes of coronary heart disease    
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 PUQALY. An Item Reduction Survey - Pressure Ulcer Quality-Adjusted Life Years (PUQALY): An Item Reduction SurveyIn Set-Up Pending NHS PermissionObservationalNo
 Qualitative enquiry into stakeholder views of dyadic art psychotherapy - Qualitative research into how key stakeholder view the delivery of dyadic art psychotherapyIn Set-Up Pending NHS PermissionObservationalNo
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder   
 Record - Linkage Study to Determine the Past and Current Burden of Diagnosed Hepatitis C in Scotland - Record - Linkage Study to Determine the Past and Current Burden of Diagnosed Hepatitis C in Scotland and the Influence of a Hepatitis C Diagnosis on Alcohol - Related HospitalisationClosednot specifiedN/A
 Recruitment Asians Asthma - Strategies to promote recruitment of South Asians (Indians, Pakistanis and Bangladeshis) into UK asthma studies.    
 Reducing the frequency and severity of voices: AVATAR Clinical Trial - Reducing the frequency and severity of auditory hallucinations: A randomised clinical trial of a novel Audio-Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR therapy) compared to supportive counsellingIn Set-Up Pending NHS PermissionInterventionalNo
 Remove - RemoveOpenInterventional 
 Remove - Remove   
 Remove - Remove   
 RESPONDS Interview Study - Bridging the knowledge and practice gap between domestic violence and child safeguarding: developing policy and training for general practice.In Set-Up NHS Permission ReceivedObservationalNo
 SAHSC BioResource - South East Scotland SAHSC Human Annotated BioResource   
 Self management education for adults with asthma - A multi centre randomised controlled trial of lay-led, individualised self-management education for adults with asthma   
 Self management education fro adults with asthma - A multi centre randomised controlled trial of lay-led, individualised self-management education for adults with asthma.   
 Serotonergic function in adults with Prader-Willi syndrome version 1 - From genotype to psychiatric phenotype: serotonergic function in adults with Prader-willi syndrome   
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Simulation in Cardiology - Developing, Implementing and Evaluating Simulation Applications and Technologies for Interventional CardiologistsOpenObservationalNo
 Simvastatin Pulmonary Hypertension - Simvastatin in Pulmonary Hypertension    
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SOLE Study of Letrozole Extention - A phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant endocrine therapy for postmenopausal women with hormone-receptor positive, node positive early stage breast cancer.OpenInterventionalYes, within lead country only
 SPIRiT - A feasibility study to inform the design of a national multi-centre RCT to evaluate if reducing serum phosphate to normal levels improves clinical outcomes including mortality, cardiovascular events, bone pain or fracture in patients on dialysisIn Set-Up NHS Permission ReceivedInterventionalNo
 Spontaneous smoking cessation prior to lung cancer diagnosis: a case control study - Spontaneous smoking cessation prior to lung cancer diagnosis: a case control study   
 Staff beliefs and perceived barriers towards oral health care provisions in stroke units in Scotland - Staff beliefs and perceived barriers towards oral health care provisions in stroke units in Scotland.In Set-Up NHS Permission Received  
 Stem cells for drug discovery - Stem cells for Biological Assays of Novel drugs and prediCtive toxiCology (StemBANCC)In Set-Up Pending NHS PermissionObservationalNo
 STOPIT - STOPIT: Study Of Public place Intervention on Tobacco exposure   
 Studies of the molecular pathogenesis of adrenocortical tumours - Studies of the molecular pathogenesis of adrenocortical tumoursOpen  
 Study Genetics Asthma - National Family Collection for the Study of the Genetics of Asthma    
 study management anti-retroviral therapy - A large simple study comparing two strategies for management of anti-retroviral therapy (CPCRA 065) [The SMART study]    
 Study Musculoskeletal Health - The Hertfordshire Cohort Study: Aspects of Musculoskeletal Health   
 Support Back - Internet Intervention Supporting Management of Low Back Pain in Primary Care: a feasibility studyIn Set-Up Pending NHS Permission  
 SWS Cohort Study at Age 10-12 Years - Southampton Women's Survey cohort study at age 10-12 years: Developmental influences on body composition, metabolism and thinking skillsIn Set-Up Pending NHS PermissionObservationalNo
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The E.G. Scan Study - A Multi-centre Observational Study to Assess a Novel Endoscopic Device in Imaging the Upper Gastrointestinal (GI) tract: The E.G. Scan Study   
 The effect of workplace stress on eating behaviour - The Integrated Neurobiology of Food Intake, Addiction and Stress (NeuroFAST); the effect of workplace stress on eating behaviourIn Set-Up Pending NHS PermissionObservationalNo
 The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc - The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)   
 The Impact of Delayed Puberty on Adolescent Brain Development - A behavioural and neuroimaging study investigating the impact of constitutional delayed onset of puberty in males aged 14-16 years on risk-taking behaviour and brain development using structural and functional Magnetic Resonance Imaging (MRI)OpenObservationalNo
 The Impact of Ethnicity on the High Density Lipoprotein (HDL) Proteome - The Impact of Ethnicity on the High Density Lipoprotein (HDL) ProteomeIn Set-Up Pending NHS PermissionObservationalNo
 The neural basis of gambling cognitions - The neural basis of gambling cognitions: relevance for vulnerability and treatment of gambling addictionIn Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 THRIVE - Trial of Healthy Relationship Initiatives for the Very Early-yearsIn Set-Up Pending NHS Permission  
 TIGO matching interventions to identified determinants of practice - Tailored Implementation of Guidelines for Obesity – matching implementation interventions to identified determinants of practiceIn Set-Up Pending NHS Permission  
 TPMT genotyping prior azathioprine treatment. - A prospective randomised controlled trial of thiopurine methyltransferase (TPMT) genotyping in the management of patients, prior to commencement of azathioprine treatment.    
 Trajectories of Outcome in Neurological Conditions Sub- Phase 4 Interviews and Questionnaire - Trajectories of Outcome in Neurological Conditions: Quality of Life (QoL) and neurological diseases Sub- Phase 4 Interviews and QuestionnaireIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Trajectories of Outcome in Neurological Conditions Sub-Study 4 Longtitudinal - Trajectories of Outcome in Neurological Conditions: Quality of Life (QoL) and neurological disease Sub-Study4 LongtitudinalIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 TRALIS - A randomised double-blind placebo-controlled trial in rheumatoid arthritis of lisinopril.- TRALIS    
 Transient Ischaemic attack - Peripheral inflammation and vascular events: a multi-centre, follow-up study of transient ischaemic attack and minor stroke outpatients   
 TREMERA - Prospective, Single-centre, Open-label, Randomised, Pilot Study Assessing the Changes in Expression of JAKSTAT and Speed & Depth of Remission Induced by Tocilizumab & Methotrexate Combination and Tocilizumab Monotherapy in Patients with Early Rheumatoid Arthritis (TREMERA).In Set-Up Pending NHS PermissionInterventionalNo
 TRENOB - A pilot study to investigate the efficacy of CoblationTM of the nasal turbinates in the treatment of nasal obstruction    
 TwistDx RPA: Sample Choice and Performance Evaluation - TwistDx Chlamydia Trachomatis Recombinase Polymerase Amplification Assay: Sample Choice and Performance EvaluationIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 UEEMRD - Urinary Endothelin-1 as an Early Marker of Renal Dysfunction    
 United Kingdom Rotator Cuff Surgery Study (UKUFF) - What is the clinical and cost effectiveness of open versus arthroscopic surgical repair for tears of the rotator cuff?   
 Urinary proteomics in prostate cancer - Urinary and Serum proteomics in prostate cancerIn Set-Up Pending NHS PermissionObservationalNo
 Use of placental vessels for pharmacokinetic screening studies in pre-eclampsia - Use of placental vessels for pharmacokinetic screening studies in pre-eclampsia   
 Validation of a Long-Term Post-Stroke Checklist - Validation of a Long-Term Post-Stroke ChecklistIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 VTEC - VTE in care homes (VTEC)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 WARTS trial - Cryotherapy versus salicylic acid for the treatment of verrucae: a randomised control trial.Closednot specifiedN/A
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Wheel-SAS - Clinical Evaluation of a Wheelchair Stability Assessment SystemIn Set-Up Pending NHS PermissionObservationalNo
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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