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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F- Fluoride Assessment of Aortic Bioprostheses Durability and Outcome - 18F- Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 18F-D4-FCH in MIBC - Feasibility study of uptake of 18F-D4-Fluorocholine (18F-D4-FCH) PET/CT and correlation with choline kinase alpha expression in Muscle Invasive Bladder Cancer (MIBC)In Set-Up Pending NHS PermissionObservational 
 18F-­FMC and MRS in gliomas - 18F­-Fluoromethylcholine (18F-FMC) PET/CT and magnetic resonance spectroscopy (MRS) Imaging and tissue biomarkers of cell membrane turnover in primary brain gliomasIn Set-Up Pending NHS Permission  
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Acelarin(NUC1031) plus Carboplatin for recurrent ovarian cancer - Phase IB open label study to assess the safety, pharmacokinetics and clinical activity of Acelarin (NUC-1031) given on days 1 & 8 with carboplatin on day 1, every three weeks for 6 cycles in participants diagnosed with recurrent ovarian cancer.In Set-Up Pending NHS Permission  
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Anthropometric data for MoRoW3 - Development of a Device for the Motorised Rehabilitation of Walking (MoRoW3)In Set-Up Pending NHS Permission  
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 ASPIRE: Action to Support Practices Implementing Research Evidence - ASPIRE: Action to Support Practices Implementing Research Evidence. Piloting tailored intervention package designed to improve adherence to high impact clinical recommendations.In Set-Up Pending NHS Permission  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Body composition & chemo response & toxicity in early breast cancer - CANDO-2: A feasibility and pilot cohort study to investigate body composition and chemotherapy response and toxicity in early breast cancerIn Set-Up Pending NHS Permission  
 Bumetanide in Hypokalaemic Periodic Paralysis - A randomised, double-blind, placebo-controlled, phase II clinical trial with a cross-over design assessing efficacy of a single dose of bumetamide in reducing focal attack severity in hypokalaemic periodic paralysis assessed using the McManis protocol.In Set-Up Pending NHS PermissionInterventionalNo
 CALIBER - A phase II randomised feasibility study of chemoresection and surgical management in low risk non muscle invasive bladder cancerIn Set-Up NHS Permission ReceivedInterventionalYes, within and outside lead country
 CamBMT1 - Cambridge Brain Mets Trial 1: A proof­ of principle phase 1b / randomised phase 2 study of afatinib penetration into cerebral metastases for patients undergoing neurosurgical resection, both with and without prior low­dose, targeted radiotherapyIn Set-Up Pending NHS PermissionInterventional 
 Care Augmentation by Location-linked messaging CALL-Me - Assessment of care augmentation by location-linked messaging in amyotrophic lateral sclerosis with respiratory impairment compared with current standard careIn Set-Up Pending NHS PermissionInterventionalNo
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Central neural control of lower urinary tract function V1.00 - A magnetic resonance imaging study evaluating the central neural correlates of lower urinary tract function and dysfunction in neurogenic and idiopathic bladder conditionsIn Set-Up Pending NHS PermissionObservational 
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical Phenotyping and Genotyping of HIV-Associated Neuropathy - Clinical Phenotyping and Genotyping of HIV-Associated Sensory Neuropathy : The HIV-POGO studyIn Set-Up Pending NHS PermissionObservationalNo
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 Controlled Study of Exhaled breath in type 1 diabetes - A randomized controlled study to evaluate non-invasive measurement of plasma glucose from exhaled breath by using mass spectrometry in type 1 diabetesOpenInterventionalNo
 CRT of hydration in last days of life (feasibility study) - A cluster randomised trial of alternative forms of hydration in cancer patients in the last days of life (feasibility study)In Set-Up Pending NHS PermissionInterventional 
 CULPRITSHOCK - Prospective randomized multicenter study comparing immediate multivessel revascularization by PCI versus culprit lesion PCI with staged nonculprit lesion revascularization in patients with acute myocardial infarction complicated by cardiogenic shock.In Set-Up Pending NHS PermissionInterventionalNo
 D3 dopamine receptor function in dyskinetic PD patients - D3 and D2high dopamine receptor function in Parkinson’s disease patients with levodopa-induced dyskinesiasIn Set-Up Pending NHS PermissionObservationalNo
 Decision Making with Teenagers, Parents and Clinicians - Principles and practices for involving young people in decision making about their care and treatment: A prospective participant observation study to inform policy and practiceIn Set-Up Pending NHS PermissionObservational 
 Deep and Frequent Phenotyping Feasibility - Deep and Frequent Phenotyping for experimental medicine in Dementia: A Feasibility Study in the NIHR Translational Research Collaboration in DementiaIn Set-Up Pending NHS PermissionObservationalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing A Blood Test For Early Stage NSCLC - Developing A Blood Test For Early Stage Non-Small Cell Lung CancerIn Set-Up Pending NHS PermissionObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diffusion imaging in gliomas - Quantitative diffusion imaging for early treatment response and progression evaluation in adult high grade gliomas; a multicentre study.In Set-Up Pending NHS Permission  
 DINOSAUR Paediatric Bone and Joint Study: Qualitative component - DINOSAUR Paediatric Bone and Joint Study: Qualitative componentIn Set-Up Pending NHS PermissionObservational-unknown-
 DISCHARGE Pilot Study - Quality of Life and Microcosting in Patients with Stable Angina / Chest Pain: Pilot-study to the DISCHARGE trialIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 DRN 900 - study diabetesIn Set-Up Pending NHS PermissionObservational 
 DSD Life - A Multi-Centre Clinical European Study on the Outcome of Surgical, Hormonal and Psychological Intervention in Disorders of Sexual Development.   
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 EDIBLE v1.0 - Evaluating Dietary Intervention Before surgicaL treatment for EpilepsyIn Set-Up Pending NHS PermissionInterventional-unknown-
 Efficacy of Consuming LcS In Spinal cord injury Patients (ECLISP) - Effect of Lactobacillus casei Shirota in preventing antibiotic associated diarrhoea (AAD) including Clostridium difficile associated diarrhoea (CDAD) in patients with spinal cord injuries: a multicentre, randomised, double-blind, placebo-controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 ElaTION - The efficacy and cost effectiveness of Real Time Ultrasound Elastogrophy in the investigation of thyroid nodules and the diagnosis of thyroid cancer.In Set-Up Pending NHS PermissionInterventional and Observational 
 EORTC 90091-10093 - Trastuzumab in HER2-negative Early breast cancer as Adjuvant Treatment for Circulating Tumour Cells (CTC) ("Treat CTC" trial)In Set-Up Pending NHS Permission  
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Evaluation of the Schwartz Center Rounds - Mapping Study: Phase 1 of a Longitudinal National Evaluation of Schwartz Centre Rounds: an intervention to enhance compassion in the relationships between staff and patients though providing support for staff and promoting their wellbeingIn Set-Up Pending NHS PermissionObservationalNo
 Exploring ED attendance by patients with advanced cancer - How do patients with advanced cancer decide to attend the emergency department, and what influences their decision-making at this time? A qualitative case studyIn Set-Up Pending NHS Permission  
 FACTS, Version 1 - Food Allergy and Critical allergen Threshold StudyIn Set-Up Pending NHS PermissionObservationalNo
 FACTS, Version 1. - Food Allergy and Critical allergen Threshold Study   
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitation   
 Full thickness laparo-endoscopic excision for benign colonic polyps - An observational study of full thickness laparo-endoscopic excision for benign colonic polyps (FLEX)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 GALA-­BIDD - Improving the intra­operative diagnosis of high-grade glioma using a fluorescence biomarkerIn Set-Up Pending NHS Permissionnot specified 
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic Contribution to Drug Induced Renal Injury in children - The Genetic Contribution to Drug Induced Renal Injury in adults and children: The Drug Induced Renal Injury Consortium (DIRECT)In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENPET: Targeted FCH-PET imaging based on genetic profile - Detection of metastatic disease in BRCA mutation carrier prostate cancer patients with optimised imaging protocolsIn Set-Up Pending NHS PermissionInterventional 
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GoSHARE-ADR - Genetics of the Scottish Health Research Register - Adverse Drug Reactions   
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 HERALD-1: HEpatic Resection Analgesia and Length of time to Discharge - Short-term Outcomes with Intrathecal Opioid and Patient Controlled Analgesia versus Thoracic Epidural Analgesia for Hepatic Resection: A Randomised Controlled Trial.In Set-Up Pending NHS PermissionInterventionalNo
 HI-Light Vitiligo Trial - Home Interventions and Light therapy for the treatment of vitiligoIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 How outcome measures work in palliative care (Version 2) - How outcome measures work in palliative care - A study of the implementation of outcome measures in practice (Version 2)In Set-Up Pending NHS PermissionObservationalNo
 HSDR Mortality Alerts - Evaluation of a national surveillance system for mortality alertsIn Set-Up Pending NHS Permission  
 Human peripheral blood studies to research immunological lung disease - Human peripheral blood cell laboratory studies to investigate the role of immune and inflammatory pathways in respiratory disease.In Set-Up Pending NHS PermissionObservationalNo
 HWATIP - Hypoglycaemia worsens atherosclerosis through inflammatory pathwaysIn Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identification of risk factors for developing Acute Kidney Injury in patients undergoing orthopaedic - Identification of risk factors for developing Acute Kidney Injury in patients undergoing orthopaedic surgery.   
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Illness Perception in Glaucoma - Illness Perception in Glaucoma (IPIG) StudyIn Set-Up Pending NHS PermissionObservationalNo
 Imaging in Transforming Gliomas - Translocator Protein Expression in Transforming GliomasIn Set-Up Pending NHS Permission  
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Immunity to respiratory tract pathogens-version 1 - Investigation of immune responses to respiratory tract pathogens and vaccines in adenotonsillar cells from humansIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 IMMUNOTACE - A randomised phase II clinical trial of conditioning cyclophosphamide and chemoembolisation with or without vaccination with dendritic Cells pulsed with HepG2 lysate in vivo in patients with Hepatocellular CarcinomaIn Set-Up Pending NHS PermissionInterventional 
 Immunotherapy for prostate cancer - Development of novel immunotherapies for prostate cancerIn Set-Up Pending NHS Permission  
 IMox study - Intramuscular oxytocics: A multi-centre randomised comparison study of intramuscular Carbetocin, Syntocinon and Syntometrine for the third stage of labour following vaginal birthIn Set-Up Pending NHS PermissionInterventionalNo
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Inflammation and disability progression in multiple sclerosis - Inflammation and disability progression in multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Informed Consent for PCI: Questionnaire Study - Mixed methods study to optimise informed consent for Percutaneous Coronary Intervention (PCI) in clinical practice: Questionnaire StudyIn Set-Up Pending NHS PermissionObservational 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 INTRA-DIALYTIC EXERCISE IN RENAL FAILURE - PrEscription of intraDialytic exercise to improve quAlity of Life (PEDAL Trial) in patients with chronic kidney disease   
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating immunogenicity to biopharmaceutics cross sectional study - Anti-Biopharmaceutical Immunization: prediction and analysis of clinical relevance to minimize the RISK: cross sectional studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 JAVA-P - A phase II study of Cabazitaxel chemotherapy in relapsed locally advanced and/or metastatic carcinoma of the penisIn Set-Up Pending NHS Permission  
 LCI-SEARCH - Lung Clearance Index (LCI) as a Sensitive measure of Early Airway Change in Cystic Fibrosis.In Set-Up Pending NHS PermissionObservationalNo
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MAGENTA ­ v1.2 - MAGENTA: Metabonomic-genomic signature correlates of clinical resistance in metastatic cancer treated with anti-EGFR therapyIn Set-Up Pending NHS PermissionObservational 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Metformin for endometrial cancer RCT - Presurgical metformin for women with endometrial cancer: a randomised placebo controlled trialIn Set-Up Pending NHS PermissionInterventional 
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Molecular profiling for lymphoma - Molecular profiling for lymphomaIn Set-Up Pending NHS PermissionObservational 
 Monitoring and Managing from Ward to Board - Information Systems: Monitoring and Managing From Ward to BoardIn Set-Up Pending NHS Permission  
 MRI with DTI tractography to road-map prostatic neurovascular bundles - Diffusion tensor imaging (DTI tractography) in the prostate: Road-mapping the neurovascular bundle prior to radical prostatectomy.In Set-Up Pending NHS Permission  
 Native T1 Mapping in Rare Diseases - Native T1 Mapping by Cardiovascular Resonance Imaging in Rare Diseases A New Method to Improve Patient CareIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Non invasive cardiac output monitoring to reduce complication in NOF - Non invasive cardiac output monitoring to guide goal directed fluid therapy in high risk patients undergoing urgent surgical repair of proximal femoral fractures.In Set-Up Pending NHS PermissionInterventionalNo
 Non-Alcoholic Fatty Liver Disease in People with Diabetes - The Prevalence and Risk Factors for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus   
 Observational Study to Determine Prognostic Factors in Skin Lymphoma - Multicenter Observational Prospective Study For The Identification Of Prognostic Factors In Patients With Mycosis Fungoides/Sezary Syndrome: Proposal For An International Prognostic Index For Cutaneous LymphomaIn Set-Up Pending NHS PermissionObservational 
 Obstructive sleep apnoea and retinal vascular reactivity - Effect of obstructive sleep apnoea on retinal vasculature reactivity following CPAP withdrawalIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 ON-EPIC Nitrate supplementation to enhance rehabilitation in COPD - ON-EPIC Oral nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary diseaseIn Set-Up Pending NHS PermissionInterventionalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PALLET - A phase II randomised study evaluating the biological and clinical effects of the combination of palbociclib with letrozole as neoadjuvant therapy in post-menopausal women with ER+ primary breast cancerIn Set-Up Pending NHS PermissionInterventional 
 PANasta - Cattell Warren versus Blumgart techniques of pancreatico-jejunostomy following pancreato­duodenectomy ­a double blinded multicentred trial.In Set-Up Pending NHS PermissionInterventional 
 PANTERA - Exercise training as a novel primary therapy for men with localised prostate cancer: the PANTERA trial (Prostate cAncer Novel ThERApy)In Set-Up Pending NHS Permission  
 Patient Centred Assessment Method (PCAM) - Patient Centred Assessment Method (PCAM): improving nurse led biopsychosocial assessment of patients with long term conditions and co-morbid mental health needsIn Set-Up Pending NHS Permission  
 Patient reported outcomes in prostate cancer radiotherapy - Patient reported outcomes in patients treated within a randomised trial of image-guided radiotherapy for localised prostate cancerIn Set-Up Pending NHS Permission  
 Patients' experiences of cancer diagnosis in UK, Sweden and Denmark - A comparative qualitative study of patients' experiences of cancer diagnosis in England, Denmark and Sweden: can comparative analysis of patients' narratives help us identify how to improve cancer services?In Set-Up Pending NHS PermissionObservational 
 PATRIOT - A Phase I Study to assess the Tolerability, Safety and Biological Effects of a Specific Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor (AZD6738) as a Single Agent and in Combination with Palliative Radiation Therapy in Patients with Solid TumoursOpenInterventional 
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 POINT OF CARE TESTING FOR RESPIRATORY PATHOGENS (Resp ED POCT) - A CONTROLLED CLINICAL TRIAL INVESTIGATING THE IMPACT OF POINT OF CARE TESTING FOR ‘ATYPICAL’ PNEUMONIA, BORDETELLA PERTUSSIS AND VIRAL PATHOGENS ON PATIENT PATHWAYS, ANTIMICROBIAL CONSUMPTION AND COST-EFFICIENCY.In Set-Up Pending NHS PermissionInterventionalNo
 POMP v0.1 - 'In House' Preimplantation Oxygenated Hypothermic Machine Perfusion Reconditioning after Cold Storage versus Cold Storage alone in ECD Kidneys from Brain Dead DonorsIn Set-Up Pending NHS Permission  
 PREDICT (Sarcoma) - Can we reliably detect viable, dying or dead Ewing’s Sarcoma cells in peri-tumoral tissue following induction chemotherapy?In Set-Up Pending NHS PermissionObservational 
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting drug and radiation sensitivity in thoracic cancers - Molecular markers of early detection, therapeutic stratification and response in thoracic cancersIn Set-Up Pending NHS PermissionObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Prognostic Biomarkers in Epilepsy (ELMO) Study - Prognostic Biomarkers in Epilepsy (ELMO) StudyIn Set-Up Pending NHS PermissionObservational-unknown-
 PROWESS - A feasibility study of delivering a culturally adapted group based breast cancer self-management intervention in a community setting, designed to enhance confidence to self-manage following treatment for primary breast cancer and promote peer support, among women from different ethnic and socio-economic backgroundsIn Set-Up Pending NHS Permission  
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 Pulse oximeter respiratory monitoring in obstructive sleep apnoea - Respiratory monitoring by pulse oximetry waveform analysis in children with suspected obstructive sleep apnoeaIn Set-Up Pending NHS PermissionObservationalNo
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Red cell transfusion and QoL in myelodysplastic syndromes (REDDS) - Red blood cell transfusion thresholds and Quality of Life in myelodysplastic syndromes: a pilot, feasibility study.In Set-Up Pending NHS PermissionInterventionalNo
 redi: Risk-assessed Exercise & Diet Intervention - Stage 1 - redi: Risk-assessed Exercise and Diet Intervention for men with prostate cancer: Stage I - Proof of conceptIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Risk assessment for PTBD +/stenting - Risk stratification scoring for percutaneous transhepatic biliary drainage (PTBD), with or without stenting.In Set-Up Pending NHS Permission  
 SAMS Reliability - Software Architecture for Mental Health Self Management Reliability and Proof of Concept studyIn Set-Up Pending NHS PermissionObservational 
 SGH EnviroDental ver 1 - A study into the elution of monomers from tooth-coloured filling materials into the environment via bodily excretions.In Set-Up Pending NHS PermissionObservationalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 SMARTCap - SMARTCap: A field-deployable blood test for stroke, capable of detecting brain ischaemia from the earliest stages of pathologyIn Set-Up NHS Permission ReceivedObservationalNo
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SORAMIC - Evaluation of Sorafenib in combination with local microtherapy guided by GdEOBDTPA enhanced MRI in patients with inoperable hepatocellular carcinomaIn Set-Up Pending NHS PermissionInterventional 
 SPLENDOUR: Survival imProvement in Lung cancEr iNduced by DenOsUmab theRapy - A randomised, open-­label phase III trial evaluating the addition of denosumab to standard first­line anticancer treatment in advanced NSCLC.In Set-Up Pending NHS PermissionInterventional 
 Supporting excellence in end of life care (SEED): Workstream 6 - Supporting Excellence in End of life care in Dementia via individual care plans (SEED): Workstream 6In Set-Up Pending NHS PermissionObservational 
 Testing a new stepwise strategy for the management of renal anaemia - Testing a new stepwise strategy for the management of renal anaemia in primary care: An exploratory cluster randomised trialIn Set-Up Pending NHS PermissionInterventional and Observational 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The ADENOMA Study - The ADENOMA study - Accuracy of Detection using ENdocuff Optimisation of Mucosal AbnormalitiesIn Set-Up Pending NHS PermissionInterventionalNo
 The AKORDD study of Outreach in Acute Kidney Injury - The AKORDD study: Acute Kidney Outreach to Reduce Deterioration and Death A feasibility study to determine the best implementation leading to a Cluster trial   
 The Babelfish Control study - Developing a Continuous Non-invasive Intracranial Pressure Monitoring Device: The Babelfish Control Study.In Set-Up Pending NHS PermissionObservational 
 The current impact of personal health budgets - The Current Impact Of Personal Health Budgets On Service Providers And Patient EmpowermenIn Set-Up Pending NHS Permission  
 The development and implementation of automated methods for echo - The development and implementation of automated methods for the reproducible assessment of aortic stenosis and mitral regurgitationIn Set-Up Pending NHS Permission  
 The development of an app for exercises after breast cancer surgery - Development and field-testing of a mobile application for self-management of exercises after breast cancer surgeryIn Set-Up Pending NHS Permission  
 The genetic aetiology of chemotherapy induced cardiotoxcity - The genetic aetiology of acute early onset chemotherapy induced cardiotoxicity in childrenIn Set-Up Pending NHS PermissionObservational 
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 TIER - A Phase I/II Study of Thiotepa, Ifosphamide, Etoposide and Rituximab for the treatment of relapsed or refractory primary central nervous system lymphomaIn Set-Up Pending NHS PermissionInterventional 
 Trajectories of Outcome in Neurological Conditions Sub-Study 4 Longtitudinal - Trajectories of Outcome in Neurological Conditions: Quality of Life (QoL) and neurological disease Sub-Study4 LongtitudinalIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 UK FROST (United Kingdom Frozen Shoulder Trial) - Multi-centre randomised controlled trial with economic evaluation and nested qualitative study comparing early structured physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a frozen shoulder (Adhesive Capsulitis)In Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 Understanding and improving healthcare experiences of people with HIV - Understanding and improving the healthcare service experiences of people living with HIV.In Set-Up Pending NHS PermissionObservationalNo
 Understanding Consequences - Understanding Consequences of Prostate Cancer TreatmentsIn Set-Up Pending NHS Permission  
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Use and misuse of opioid prescribing across Scotland - rates, quality, variations and explanations. - Use and misuse of opioid prescribing across Scotland - rates, quality, variations and explanations.   
 Using levels of blood in stool to estimate the risk of serious large bowel disease - The relationships between faecal haemoglobin concentration and risk of significant colorectal neoplasia in screening and symptomatic populations.   
 Using MRI tissue parameter maps to detect and delineate FCD - Using new quantitative MRI tissue parameter maps to detect and delineate focal cortical dysplasia (FCD)In Set-Up Pending NHS PermissionObservationalNo
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 VERISMART trial - Randomised trial comparing conventional versus contact force and electrical coupling index in atrial flutter ablation (VERISMART TRIAL)In Set-Up Pending NHS Permission  
 VWF-ADAMTS 13 in stroke - A prospective investigation of the VWFADAMTS 13 axis in acute ischaemic brain injury (TIAs and stroke).In Set-Up Pending NHS PermissionObservationalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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