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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A Phase I Clinical Trial of DARC - A Phase I, Storer Design, open-label, cross-sectional, single site trial of ANX776 in healthy volunteers, progressive glaucoma/glaucomasuspect/ocular hypertensive subjects and non-arteritic anterior ischaemic optic neuropathy subjects.In Set-Up Pending NHS PermissionInterventionalNo
 A Phase I Study to Assess Ebola Vaccines cAd3-EBO Z and MVA-EBO Z - A Phase Ia clinical trial to assess the safety and immunogenicity of MVA-EBO Z alone and a heterologous prime-boost immunisation with ChAd3-EBO Z and MVA-EBO Z in healthy UK volunteersIn Set-Up Pending NHS Permission  
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Alcohol Use in People Aged 50 and Over - Version 1 - Evaluation of a multi-level intervention to prevent alcohol-related harm in people aged 50 and overIn Set-Up Pending NHS PermissionObservational 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 ARTFORCE Head & Neck (2-arm study) - ARTFORCE: a randomized study with concomitant cisplatin and standard or adaptive high dose radiotherapy for advanced head and neck cancerIn Set-Up Pending NHS Permission  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Brain network structures in Idiopathic Generalised Epilepsy (IGE) - Brain network structures in predicting treatment responsiveness in patients with idiopathic generalised epilepsy (IGE)In Set-Up Pending NHS PermissionObservational 
 Calibre - CALiBRe: Assessment of the Mechanism of Action of idelalisi (CAL101) in B-cell Receptor Pathway Inhibition in CLLIn Set-Up Pending NHS Permission  
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Cellular immunity to herpesvirus infection: Studies with EBV & CMV -v1 - Cellular immunity to herpesvirus infection: Studies with Epstein-Barr virus and human cytomegalovirusIn Set-Up Pending NHS PermissionObservationalNo
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 closED. - Impact of closing Emergency Departments in England   
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Collaborative case management to aid return to work - Collaborative case management to aid return to work after long term sickness absence: a pilot randomised controlled trialIn Set-Up Pending NHS PermissionObservational 
 Comparison of patient and clinician taken HVS for candida and BV - Comparison of patient self taken vaginal swab versus clinician taken high vaginal swab for the detection of candida and bacterial vaginosis in women with vaginal discharge - pilot study.In Set-Up Pending NHS PermissionObservationalNo
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during Pregnancy   
 Confidence After Stroke Measure - Confidence After Stroke MeasureIn Set-Up Pending NHS PermissionObservational 
 CUT*HIVTHER 001 - A randomized phase I/II study to assess the safety and immunogenicity of the DNA-GTU vaccine administered by two novel routes compared to placebo in HIV-infected patients on antiretroviral therapyIn Set-Up Pending NHS PermissionInterventionalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing a system for robust and rapid simultaneous EEG-fMRI - The fast without the spurious: developing a system for robust and rapid simultaneous EEG-fMRI measurementsIn Set-Up Pending NHS PermissionObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effect of a TNF alpha inhibitor on microglial activation in MCI - A double-blind, placebo-controlled study of the effect of a TNF alpha antibody, certolizumab pegol (Cimzia), on microglial activation in amyloid PET positive patients with Mild Cognitive Impairment due to AD-Intermediate likelihoodIn Set-Up Pending NHS Permission  
 EORTC 1209EnTF - A phase II study exploring the safety and efficacy of nintedanib (BIBF1120) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.In Set-Up Pending NHS PermissionInterventionalYes, within and outside lead country
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 eSupportive Care - The development of an eSupportive care system to support children and young people with complex health care needs and their families to stay at homeIn Set-Up Pending NHS PermissionObservationalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 Genetic Frontotemporal dementia Initiative (GENFI) - Genetic Frontotemporal dementia Initiative (GENFI)In Set-Up Pending NHS PermissionInterventional 
 Genomics of diabetic retinopathy in the UK - Investigating diabetic retinopathy: A study of the clinical epidemiology, cellular and population genomics of diabetic retinopathy among primary care patients in the UK   
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Immuni-D - Vitamin D and Immunity: photosynthesis versus supplementationIn Set-Up Pending NHS PermissionObservationalNo
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Inhaled Nanoparticles, Vascular Function and Translocation - Pulmonary inflammation, the systemic translocation of inhaled nanoparticles and vascular endothelial function (PRISTINE)In Set-Up Pending NHS Permission  
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 Liaison Psychiatry Services: measurement and evaluation LP-MAESTRO WS1 - Liaison Psychiatry: Measurement and evaluation of service types, referral patterns and outcomes (LP-MAESTRO) Workstream 1In Set-Up Pending NHS PermissionObservational 
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 MARQUE: Dementia and agitation in domestic environments - Managing Agitation and Raising QUality of Life:   Stream 4: Qualitative study of people with dementia and agitation and their family  carers living in domestic environmentsIn Set-Up Pending NHS PermissionObservationalNo
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Next Generation Tests for Latent Tuberculosis Infection - Predictive values of next generation interferon gamma release assays for latent tuberculosis infectionIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Non-contact, hand-held device for measurement of respiratory rate - Development of the “BreathEasy”: a non-contact, hand-held device for measurement of respiratory rate (CPRM)In Set-Up Pending NHS PermissionInterventional 
 Non-invasive brain stimulation for dysphagia after acute stroke - Randomised controlled dose response trial of transcranial direct current stimulation for dysphagia after acute strokeIn Set-Up Pending NHS PermissionInterventional 
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke Survivors   
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PATHWAY - PATHWAY: Improving the effectiveness of psychological interventions for depression and anxiety in the cardiac rehabilitation pathway. A single blind randomised controlled trial with fourmonth and twelve month follow up comparing GroupMCT plus usual CR (intervention)with usual CR (control).   
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predicting drug and radiation sensitivity in thoracic cancers - Molecular markers of early detection, therapeutic stratification and response in thoracic cancersIn Set-Up Pending NHS PermissionObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Prevalence of Acute and Chronic Kidney Disease in the ICU (PEACE) - PrEvalence of Acute and Chronic Kidney Disease treated by renal replacement therapy in the ICU Environment (PEACE). A prospective international, multi-centre, prevalence study on the epidemiology of the use of renal replacement therapy for ICU patients who have acute kidney injury and chronic end stage kidney disease.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 PROOF-ABPM - Prospective Register Of patients undergoing repeated OFfice and Ambulatory Blood Pressure Monitoring (PROOF-ABPM)In Set-Up Pending NHS PermissionObservational 
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Role of phosphodiesterase in early de novo sporadic Parkinson's Disease - The role of phosphodiesterase 10A in early de novo sporadic PD: An in vivo positron emission tomography study   
 Rotigotine and Memory in Parkinson's. - The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive ImpairmentIn Set-Up Pending NHS PermissionInterventionalNo
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesIn Set-Up Pending NHS PermissionInterventional 
 SCOPE-ME PREM development - Study Comparing Outcomes and Patient Experience Measures for GI Endoscopy (SCOPE-ME) – Patient Reported Experience Measure (PREM) Development PhaseIn Set-Up Pending NHS Permission  
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Study of Melatonin for treatment of Nocturia in PD - Single­-centre open label exploratory phase llb pilot study of exogenous oral Melatonin for the treatment of Nocturia in adults with Parkinson’s diseaseIn Set-Up Pending NHS PermissionInterventional 
 Supporting physiotherapy adherence in children with cystic fibrosis - Development of an intervention to increase physiotherapy adherence among young children with cystic fibrosis: a Medical Research Council complex intervention framework development and feasibility study   
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 TNBC in D&G - Triple negative breast cancers and markers of HPV involvement:study in NHS Dumfries and GallowayIn Set-Up Pending NHS PermissionObservationalNo
 TORCMEK - A Phase Ib/IIa study of AZD2014 in combination with Selumetinib in patients with advanced cancersIn Set-Up Pending NHS PermissionInterventional 
 Transperineal ultrasound to assess the progress of labour - The Sono-VE Study: Assessing the acceptability and feasibility of transperineal ultrasound and developing an ultrasound based predictive model for labour outcome.In Set-Up Pending NHS PermissionObservationalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 WB-DW-MRI at 3T in relapsed multiple myeloma:early response assessment - Pilot study to evaluate diffusion-weighted MRI (DWMRI) Whole Body MRI in relapsed Multiple Myeloma at 3T: test-retest, early response assessment and exploratory imaging of renal function.In Set-Up Pending NHS Permission  
 WEBPaMS - WEB-Based Physiotherapy for People with Multiple SclerosisIn Set-Up Pending NHS PermissionInterventionalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey   
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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