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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 "CARE-Study" - Basic science study involving procedures with human participantsIn Set-Up NHS Permission ReceivedObservational 
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Accuracy of zero-­flux and ingestible thermometry - A study to determine the accuracy of zero­-flux and ingestible thermometers in the perioperative settingIn Set-Up Pending NHS PermissionObservationalNo
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Biomarkers of malignancy from pancreatic cysts - Molecular biomarkers in pancreatic cyst fluid to improve diagnostic accuracy and malignancy risk assessment.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 CALIBER - A phase II randomised feasibility study of chemoresection and surgical management in low risk non muscle invasive bladder cancerIn Set-Up NHS Permission ReceivedInterventionalYes, within and outside lead country
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical Study on POSS­PCU vascular grafts for vascular access v1.0 - A Clinical Investigation to Assess the Safety and Performance of POSS­PCU Small Diameter Grafts as Conduits in  Arteriovenous (AV) AccessIn Set-Up Pending NHS PermissionInterventional-unknown-
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CRT of hydration in last days of life (feasibility study) - A cluster randomised trial of alternative forms of hydration in cancer patients in the last days of life (feasibility study)In Set-Up Pending NHS PermissionInterventional 
 D3 dopamine receptor function in dyskinetic PD patients - D3 and D2high dopamine receptor function in Parkinson’s disease patients with levodopa-induced dyskinesiasIn Set-Up Pending NHS PermissionObservationalNo
 Decision-­making in breast cancer prevention: The ENGAGE study - Exploring decision-making in breast cancer prevention: The ENGAGE studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Defining Outcome Measures in Ocular Inflammatory Disease (DOMINO ID) - Defining Outcome Measures in Ocular Inflammatory Disease (DOMINO ID)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing A Blood Test For Early Stage NSCLC - Developing A Blood Test For Early Stage Non-Small Cell Lung CancerIn Set-Up Pending NHS PermissionObservational 
 Developing a new EEG method for the early diagnosis of dementia - Developing a new EEG method for the early diagnosis of dementia. Using novel EEG analyses to create a diagnostic test and biomarker for use withpeople with dementiaIn Set-Up Pending NHS PermissionObservationalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 DISCHARGE Pilot Study - Quality of Life and Microcosting in Patients with Stable Angina / Chest Pain: Pilot-study to the DISCHARGE trialIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Does prompt delivery of Parkinson's medication reduce length of stay? - Does prompt delivery of medication to in-patients with Parkinson's Disease decrease length of stay in hospital ?In Set-Up Pending NHS Permission  
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 ELUCIDATE- Sub Study - “Patients’ experience in the ELUCIDATE trial”In Set-Up Pending NHS PermissionObservationalNo
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Extracellular Vesicles At Rest and Stress – EVAREST Study - The Use of Blood Biomarkers, Including Extracellular Vesicles, to Improve the Diagnostic Accuracy of Cardiac Assessment by Stress EchocardiogramIn Set-Up Pending NHS PermissionObservational 
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genes & Health (version 1) - Genes & Health: a population based DNA sequencing, medical records, and recall BioResource study of British-Bangladeshi and British-Pakistani communities.In Set-Up Pending NHS PermissionObservationalNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GP Management of Prostate Cancer - General Practitioner views and understanding of prostate cancer screening and management with active surveillanceIn Set-Up Pending NHS PermissionObservational 
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hemodynamic patterns in different aortic valve and root prosthesis - In-vivo Assessment of The Hemodynamic Properties of Different Aortic Valve and Root Prosthesis Using Advanced Cardiac Magnetic Resonance Imaging and Computational Modelling TechnologyIn Set-Up Pending NHS PermissionObservational 
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Imaging of Compulsive Syndromes - Compulsive patterns of behaviour in Autism Spectrum Disorder (ASD) and Obsessive Compulsive Disorder (OCD)In Set-Up Pending NHS PermissionObservational 
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Inhaled Nanoparticles, Vascular Function and Translocation - Pulmonary inflammation, the systemic translocation of inhaled nanoparticles and vascular endothelial function (PRISTINE)In Set-Up Pending NHS Permission  
 INPDR - International Niemann-Pick Disease RegistryIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 International NiemannPick disease study - International Niemann Pick Disease Registry (NPDR)In Set-Up Pending NHS Permission  
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating non-attendance at diabetic clinics using peer research - Investigating non-attendance at diabetic clinics using peer researchOpenObservationalNo
 Is Clarithromycin a potential treatment for cachexia in lung cancer? - Is Clarithromycin a potential treatment for cachexia in people with lung cancer?In Set-Up Pending NHS PermissionInterventional 
 Isoprenaline infusion as a method of induction of Atrial Fibrillation - Isoprenaline infusion as a method of induction of Atrial Fibrillation; A randomised controlled trial investigating the use of Isoprenaline to induce an episode of atrial fibrillationIn Set-Up Pending NHS PermissionInterventional 
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MAGENTA ­ v1.2 - MAGENTA: Metabonomic-genomic signature correlates of clinical resistance in metastatic cancer treated with anti-EGFR therapyIn Set-Up Pending NHS PermissionObservational 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Medicines Optimisation in Cancer Pain - IMPACCT Exploratory study of a community pharmacy Pain Medicines Consultation for patients with cancer painIn Set-Up Pending NHS Permission  
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Molecular profiling for lymphoma - Molecular profiling for lymphomaIn Set-Up Pending NHS PermissionObservational 
 MR Lymphangiography in cancer-related lymphoedema - Magnetic Resonance Lymphangiography (MRL) in patients with cancer-related lymphoedemaIn Set-Up Pending NHS Permission  
 NAP SACC UK - NAP SACC UK: A feasibility cluster randomised controlled trial in child care settings to increase physical activity and healthy eating in 24 year oldsIn Set-Up Pending NHS PermissionInterventionalNo
 Neo-AEGIS - Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction.In Set-Up Pending NHS PermissionInterventional 
 On demand versus continuous use of omeprazole on reflux symptoms(3) - The effect of on demand versus continuous use of proton pump inhibitors on reflux symptoms, quality of life and self-rated health in patients with gastro-oesophageal reflux diseaseIn Set-Up Pending NHS PermissionObservational 
 OPTCARE Neuro - Evaluation of the clinical and cost­ effectiveness of Short-­term Integrated Palliative Care Services (SIPC) to OPTimise CARE for people with advanced long­term Neurological conditions (OPTCARE Neuro)In Set-Up Pending NHS Permissionnot specified 
 Optimising insoles for pressure offloading - Optimisation of custom insoles for pressure relief in patients with diabetes via finite element modellingIn Set-Up Pending NHS PermissionInterventionalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patient Centred Assessment Method (PCAM) - Patient Centred Assessment Method (PCAM): improving nurse led biopsychosocial assessment of patients with long term conditions and co-morbid mental health needsIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PIANO Study ­ PLX3397 c­KIT in advanced acral and mucosal melanoma - A Phase II Trial of PLX3397 in the Treatment of KIT Mutated Advanced Acral and Mucosal Melanoma (PIANO)In Set-Up Pending NHS PermissionInterventionalNo
 PICSO in NSTEMI Randomised Controlled Trial - PICSO in NSTEMI registry. Pressure controlled intermittent coronary sinus occlusion in NonST elevation Myocardial Infarction. An observational registryIn Set-Up Pending NHS PermissionInterventional 
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting drug and radiation sensitivity in thoracic cancers - Molecular markers of early detection, therapeutic stratification and response in thoracic cancersIn Set-Up Pending NHS PermissionObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Primary care screening for PAD in at risk groups - Can the introduction of rapid and automatic Ankle Brachial Pressure and Pulse Volume measuring device into General Practice identify the presence or absence of Peripheral Arterial Disease in cardiovascular risk groups?In Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 Provision of GH replacement following SAH: a feasibility study - Growth Hormone Replacement therapy for adults who have developed Growth Hormone Deficiency (GHD) following a Subarachnoid Haemorrhage (SAH). A feasibility study to assess acceptability to patients and inform future study design.In Set-Up Pending NHS Permissionnot specifiedNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 RHAPSODY Version 1 - Research and strategy for dementia in the young   
 Rotigotine and Memory in Parkinson's. - The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive ImpairmentIn Set-Up Pending NHS PermissionInterventional 
 Selective Coronary vein sampling in Left Bundle Branch Block and CRT - The effects of pacing on cardiac work on patients in Left bundle branch block and following cardiac resynchronisation therapyIn Set-Up Pending NHS PermissionObservationalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 STAND UP - Experimental intervention - STAND UP Sedentary behaviour in older adults: investigating a new therapeutic paradigm Work Package 3: Investigating the effect of sedentary time, reduced sedentary time and increased light-intensity physical activity on metabolic and psychological health in older adultsIn Set-Up Pending NHS PermissionObservational 
 Studies into SAH v1.0 - Studying subarachnoid haemorrage using multiple techniquesIn Set-Up Pending NHS PermissionObservational 
 Systemic inflammation in DLB and AD - Systemic inflammation in Dementia with Lewy Bodies and Alzheimer's DiseaseIn Set-Up Pending NHS PermissionObservationalNo
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Taurolidine 2% catheter locking to prevent CRBSI - Taurolidine 2% catheter locking to prevent catheter related bloodstream infections in patients on home parenteral nutrition with a high infection risk and those with a new central venous access device : A double-blind multicenter randomized controlled trial under guidance of the Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of ESPENIn Set-Up Pending NHS PermissionInterventionalNo
 Testing a new stepwise strategy for the management of renal anaemia - Testing a new stepwise strategy for the management of renal anaemia in primary care: An exploratory cluster randomised trialIn Set-Up Pending NHS PermissionInterventional and Observational 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The development and implementation of automated methods for echo - The development and implementation of automated methods for the reproducible assessment of aortic stenosis and mitral regurgitationIn Set-Up Pending NHS Permission  
 The genetic aetiology of chemotherapy induced cardiotoxcity - The genetic aetiology of acute early onset chemotherapy induced cardiotoxicity in childrenIn Set-Up Pending NHS PermissionObservational 
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 VERISMART trial - Randomised trial comparing conventional versus contact force and electrical coupling index in atrial flutter ablation (VERISMART TRIAL)In Set-Up Pending NHS Permission  
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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