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UKCRN Study Portfolio


Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 “Test n Treat”: a feasibility trial of rapid STI testing and treatment - “Test n Treat (TnT)”: a cluster randomised feasibility trial of frequent, rapid testing and same day on-site treatment to reduce rates of chlamydia and gonorrhoea in high risk Further Education college studentsIn Set-Up Pending HRA ApprovalInterventionalNo
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A 34­week Follow­up to: MK­0431A in Pediatric Patients with Type 2 Diabetes Mellitus - A 34­week Follow­ up to: A Phase III, Multicenter, Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the  Safety and Efficacy MK­0431A (A Fixed Dose Combination Tablet of  Sitagliptin and Metformin) in Pediatric Patients with Type 2 Diabetes Mellitus.   
 A case study of a Maternity Service Development Programme - A case study of a Maternity Service Development Programme, and its influence on maternity services and inter­agency collaboration   
 AbSeS - The Abdominal Sepsis Study: Epidemiology of Etiology and OutcomeIn Set-Up Pending HRA ApprovalObservationalYes, within and outside lead country
 Acute effect of Donepezil on transcranial magnetic stimulation paramet - Acute effect of single dosing with Donepezil on cholinergic cortical circuits in Alzheimer's disease: A longitudinal transcranial magnetic stimulation study   
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Adolescents living with HIV project (ALHIV) - The Passages Project: Global research into speciality care and transition for adolescents living with HIV.In Set-Up Pending NHS PermissionObservational-unknown-
 Adult onset type 1 - diabetes ­ the PROCEED study - An Exploratory Study to Develop a Supportive Programme of Care for Adult Onset - Type 1 Diabetes­ the PROCEED study.   
 AMOUR - Aflibercept (Eylea®) for macular oedema associated with underlying Retinitis Pigmentosa (AMOUR)In Set-Up Pending HRA ApprovalInterventionalNo
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Application of 3D facial imaging in the management of orbital disease - Application of 3D facial imaging in the management of orbital diseaseIn Set-Up Pending NHS PermissionObservationalNo
 ARIES: App to support Recovery in Early Intervention Services - App to support Recovery In Early Intervention Services (the ARIES study): Usability testing and pilot randomized controlled trial of a supported self-management smartphone application for psychosis   
 ARTESiA:   Apixaban in patients with device-detected sub-clinical AF - APIXABAN FOR THE REDUCTION OF THROMBO-EMBOLISM IN PATIENTS WITH DEVICE-DETECTED SUB-CLINICAL ATRIAL FIBRILLATION.   
 Astroglial activation, ß-amyloid deposition and neuronal activity - Multi-modal imaging correlates of astroglial activation, ß-amyloid deposition and neuronal activity as markers of cognitive impairment in AD   
 Baronet - Biological and radiological outcomes of neoadjuvant endocrine treatment (BARONET).   
 BeST? - The Best Services Trial (BeST?): Effectiveness and cost-effectiveness of the New Orleans Intervention Model for Infant Mental Health   
 BeST?. - The Best Services Trial (BeST?): Effectiveness and cost-effectiveness of the New Orleans Intervention Model for Infant Mental HealthIn Set-Up Pending NHS PermissionInterventional-unknown-
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Blood-borne Virus Testing in the ED - A qualitative study to assess the acceptability and feasibility of blood-borne virus testing in an Emergency Department setting   
 Bowditch revisited: defining the optimum heart rate range in CHF - Bowditch revisited: defining the optimum heart rate range in chronic heart failureIn Set-Up Pending NHS PermissionInterventionalNo
 Brain imaging and cognition in DMD - Brain imaging and cognition in patients with Duchenne Muscular Dystrophy   
 CAH appearance surgery study Version 1 - Managing large clitoris in childhood in girls with CAH: An investigation of the psychological impact of current treatment strategies.   
 Can surface roughness predict progression of tooth wear? - Can surface roughness predict progression of tooth wear in patients with dietary origins of acid? An in situ study   
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 CATCH-uS: Children with ADHA in transition to adult services - Young people with Attention Deficit Hyperactivity Disorder (ADHD) in transition from children's services to adult services (CATCh-uS): a mixed methods project using national surveillance, qualitative and mapping studies.In Set-Up Pending NHS PermissionObservationalNo
 CELTIC - CELTIC   
 CFMATTERS Study - Cystic Fibrosis Microbiome determined Antimicrobial Therapy Trial in Exacerbations: Results StratifiedIn Set-Up NHS Permission ReceivedInterventional and ObservationalYes, within and outside lead country
 Changing health behaviours prior to surgery: What are your views? - Changing health behaviours prior to surgery: What are your views?In Set-Up NHS Permission Receivednot specifiedYes, within lead country only
 Characterisation of myocardial inflammation in cardiomyopathies - Characterisation of myocardial inflammation in ischaemic and non-ischaemic cardiomypathiesIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Clinical study to test photonic chips as non-invasive glucose sensors - Non-invasive Monitoring of Glucose in Diabetes Mellitus:  A Pilot Study to investigate photonic chips as a glucose Sensor in a laboratory benchtop prototypeIn Set-Up Pending HRA Approval  
 Closed-loop in Pregnancy Day & Night Home Feasibility Study (CLIP24/7) - Evaluation of the feasibility, utility, safety and efficacy of day and night closed-loop insulin delivery at home in women with type 1 diabetes during pregnancyIn Set-Up Pending NHS Permission  
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Cognitive Bias Modification for Paranoia - Cognitive Bias Modification for ParanoiaIn Set-Up Pending HRA ApprovalInterventional 
 Cognitive performance among men receiving ADT - Risk and Resilience Factors Associated with Cognitive Changes Following Androgen Deprivation Therapy in Prostate Cancer Patients   
 Commissioning services for adults with learning disabilities or autism - The role of quality information in commissioning social care services for adults with learning disabilities or autism ­ a survey of commissioners in EnglandIn Set-Up Pending NHS PermissionObservational 
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 CREATE: Children Reading with Electronic Assistance to Educate - Exploratory study to evaluate the impact of tablet computers and low-vision software on education and learning in children and young people with low visionIn Set-Up Pending NHS PermissionInterventionalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diabetic Foot Ulcer Prevention System (DFUPS) - An Innovative System for the Early Identification, Monitoring, Evaluation and Diagnosis of Diabetic Foot UlcersIn Set-Up Pending NHS Permission  
 Dietary Nitrate and Monocyte-platelet aggregates in Atherosclerosis - Dietary Nitrate and Monocyte-platelet aggregates in Patients with AtherosclerosisClosedInterventionalN/A
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Does Immune Responsiveness to MSU crystals reduce over time? - Does immune responsiveness to monosodium urate crystals reduce over time? A prospective study of patients with acute goutIn Set-Up Pending NHS PermissionObservational 
 Does Gut Permeability Alter after Gastric Bypass in Type 2 Diabetes? - A pilot study to investigate whether the permeability of the intestinal mucosa is altered after Gastric Bypass surgery in patients with Type 2 diabetes.In Set-Up Pending NHS PermissionInterventionalNo
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EASI­-SWITCH v1.0 - Early switch to oral antibiotic therapy in patients with low risk  neutropenic sepsis.In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 EBC MAIN Version 2.0 dated of September 22, 2015 - The European Bifurcation Club Left Main Study; A randomized comparison of single versus dual stent implantation for distal left main true coronary bifurcation lesions.   
 ECLIPSE Study 4: Organisational climate: Qualitative study - Enhancing Cognition and quality of LIfe in the early PSychosEs (ECLIPSE) ­ Study 4: Organisational climate: Qualitative study of implementation viewsIn Set-Up Pending NHS PermissionObservationalNo
 ECLIPSE Study 5: Organisational climate: Quantitative staff survey - Enhancing Cognition and quality of LIfe in the early PSychosEs (ECLIPSE) Study 5: Organisational climate: Quantitative staff surveyIn Set-Up Pending HRA ApprovalObservational-unknown-
 Effectiveness of Ripple mapping for atrial tachycardia ablation - A prospective multicentre study of effectiveness of Ripple mapping for atrial tachycardia ablationIn Set-Up Pending NHS Permission  
 EndoSTIM for GORD in asthma - Laparoscopic EndoSTIM electrical stimulation system of the lower oesophageal sphincter for the treatment of gastro-oesophageal reflux disease (GORD) in asthma – a pilot, randomised, sham­controlled studyIn Set-Up Pending NHS PermissionInterventionalNo
 Enriching relational knowing in stroke care - Enriching relational knowing in stroke care: using appreciative action research to co-create a relationship-centered care approach to patient and family relationships and multidisciplinary working on stroke units.   
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equality for children and young people with and without learning disability (LD) - Ensuring equal access to high quality hospital care and services for children and young people with long­term conditions and /or learning disabilities: Phase 1. Pay More AttentionIn Set-Up Pending HRA ApprovalObservationalNo
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 Explant model - Human bone tissue for study the performance of bone plugs   
 Exploring the transition experiences of higher-stage medical trainees - Exploring the transition experiences of higher-stage medical trainees: A longitudinal audio-diary study across the trainee-trained/ trainee-SAS transitionIn Set-Up Pending NHS Permission  
 Expression of m.3243 A>G - Factors determining disease expression in mitochondrial disease due to the m.3243 A.G mutation   
 Facet-joint feasibility study - A multicentre double-blind randomised controlled trial to assess the clinical- and cost-effectiveness of facet-joint injections in selected patients with non-specific low back pain: a feasibility study   
 Faecal gut bacteria DNA testing in IBS patients and control subjects. - Faecal gut bacteria DNA testing in IBS patients and normal (Control) subjects with the GA­map™ Dysbiosis test   
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 FAST: Prevalence and Impact of frailty in Colorectal Surgical patients - Pilot study of the Diagnosis and Impact of Frailty in Patients Undergoing Elective Colorectal Surgery   
 Feasability Study Using TBS for Upper Limb Spasticity Version 1.0 - Feasibility Study to Investigate the Effects of Theta Burst Stimulation (TBS) to Treat Upper Limb Spasticity and Dysfunction in Spinal Cord Injured PatientsIn Set-Up Pending NHS PermissionInterventional 
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Flora Colonoscopy Twin Study - The Flora Colonoscopy Twin Study: Genetic Transmission of Components of the Human Microbiome   
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 Functional heterogeneity of human MP in health and disease - Functional heterogeneity of human mononuclear phagocytes in health and diseaseIn Set-Up Pending NHS PermissionObservational 
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 GBS2 - Accuracy of a rapid intrapartum test for maternal group B streptococcal colonisation and its potential to reduce antibiotic usage in mothers with risk factors.   
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENFI Manchester - GENFIIn Set-Up Pending NHS PermissionObservational 
 GLOWING Pilot Cluster RCT - GestationaL Obesity Weight management: Implementation of National Guidelines (GLOWING): A pilot cluster randomised controlled trial of a guideline implementation intervention for the management of maternal obesity by midwivesIn Set-Up Pending NHS PermissionInterventionalNo
 GLP-1 receptor expression in CHI - The physiology of glucagon-like-peptide-1 receptor expression in patients with CHIIn Set-Up Pending NHS PermissionObservationalNo
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 HD-CSF version 1 - HD-CSF: Studying cerebrospinal fluid to understand key CNS pathobiological targets in Huntington’s diseaseIn Set-Up Pending HRA ApprovalObservational 
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HGUS Study - A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/­ ifosfamide following surgery or in metastatic first line treatmentIn Set-Up Pending NHS Permission  
 Hippocampal and retrosplenial function in MCI patients - Sensitivity and specificity of combined tests of hippocampal and retrosplenial cortex function for the diagnosis of prodromal Alzheimer’s diseaseIn Set-Up Pending HRA ApprovalObservational 
 HIV-1 latent reservoir in co-infections V1 - The impact of co-infections on the size of the HIV-1 latent reservoirIn Set-Up Pending NHS PermissionObservationalNo
 Home testing of day and night closed loop with pump suspend feature - An open-label, multi-centre, randomised, single-period, parallel design study to assess the efficacy, safety, utility and psychosocial effect of 12 week day and night automated closed loop glucose control combined with pump suspend feature compared to sensor augmented insulin pump therapy in youth and adults with type 1 diabetes with sub-optimal glucose control under free living conditionsIn Set-Up Pending NHS PermissionInterventionalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 IBD Bioresource - The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis   
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying a high-risk profile in endometrial cancer - A prospective study for identifying a high-risk molecular profile in women with endometrial cancerIn Set-Up Pending HRA ApprovalObservational 
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 ILD Controls V1.0 - Control subjects for better understanding of pathogenesis of fibrotic lung diseaseIn Set-Up NHS Permission ReceivedObservationalNo
 Imaging Hypoxia in Cerebral Tumours (version 1) - Biological Validation of MRI and PET Biomarkers of Tissue Hypoxia in Glioblastoma MultiformeIn Set-Up Pending HRA ApprovalObservational 
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Impact and Evaluation of the BuRNTool - Impact and Evaluation of a Burns Risk Assessment of Neglect and Maltreatment in Children Tool. BuRNTool A multi centre studyIn Set-Up Pending NHS PermissionInterventional 
 Implementation of an online relatives toolkit (IMPART study) - Implementation of a relatives' toolkit (IMPART Study): Examining the critical success factors, barriers, and facilitators to the implementation of an online supported self-management intervention in the NHSIn Set-Up Pending HRA ApprovalObservationalNo
 Improving clinical practice for babies with hearing loss - Improving clinical practice for babies with hearing lossIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 INVEST in Parkinsonian Dementias - A Psychosocial Therapy to Benefit People with Parkinson’s-related Dementia: A Feasibility and Exploratory Pilot Study of Individual Cognitive Stimulation Therapy (INVEST)In Set-Up NHS Permission ReceivedInterventionalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating nociceptin release from immune cells in sepsis V1.0 - Does the release profile of nociceptin from immunocytes differ in healthy volunteers and critically ill patients with sepsis?   
 Investigating an infectious aetiology of prostate cancer - Investigating an infectious aetiology of prostate cancerIn Set-Up Pending NHS Permissionnot specifiedNo
 Is alcohol dependence associated with increased 18F Amyvid binding? - Quantification and localisation of beta­amyloid plaques in a population of alcohol dependent patients and healthy volunteers using (18F) Florbetapir (Amyvid) binding: a pilot positron emission tomography study.   
 LAAOS III - Left Atrial Appendage Occlusion Study III (LAAOS III)In Set-Up NHS Permission ReceivedInterventionalYes, within and outside lead country
 LAVA- Liver resection surgery versus thermal ablation for CLM - LAVA- Liver Resection Surgery Versus Thermal Ablation for Colorectal LiVer MetAstasesIn Set-Up Pending NHS Permissionnot specifiedYes, within and outside lead country
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 Listen-In - Listen-In: the development and testing of a web-based therapy application for patients with impaired speech comprehension caused by stroke.In Set-Up Pending NHS PermissionInterventionalNo
 Longitudinal Histories-Endometriosis PCCIU - Longitudinal History Patterns for Earlier Diagnosis of EndometriosisOpen  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 MARINAC Study - Magnetic Resonance in Infection Primed Neonatal Encephalopathy and N­-acetyl cysteineIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 Measuring neutrophil function in sepsis - The whole blood phagocytosis assay: a near patient test to promote a personalised approach to immunomodulatory therapy   
 Mechanism of action of tranexamic acid in isolated TBI v1.1 - Mechanism of action of tranexamic acid in isolated traumatic brain injury   
 Mechanisms Affecting Gut of Preterm Infants (MAGPIE) - Mechanisms Affecting the Gut of Preterm Infants in Enteral feeding trials(MAGPIE)   
 Mechanisms of Regulation of Vascular Function - Mechanisms of Regulation of Vascular FunctionClosedInterventionalN/A
 Meeting Centres - Validation of the Meeting Centres Support Programme for people with dementia and their carers in England   
 MelaTools Apps Study - MelaTools Apps Study: Skin-Self Monitoring App Assessment by Smartphone UsersIn Set-Up Pending HRA ApprovalObservational 
 Men's Attitudes to Intimate Life (MAIL) - An interview study of attitudes towards parenthood and intimate life among HIV-positive gay and bisexual men in London   
 MIBS. - Mindfulness for Irritable Bowel SyndromeIn Set-Up Pending HRA ApprovalInterventionalYes, within lead country only
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Minitub (EORTC 1208) - MINITUB REGISTRATION STUDY Prospective Registration Study on Sentinel Node (SN) Positive Melanoma Patients with Minimal SN Tumor Burden Managed without Complete Lymph Node Dissection (CLND) A Prospective Multicentre Single-Arm Registration Trial within the EORTC Melanoma Group NetworkIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 M­MARK stroke rehab device: user needs analysis - Mechanical Muscle Activity with Real­time Kinematics (M­MARK) A novel combination of existing technologies to improve arm recovery following stroke: Phase 1 user needs analysisIn Set-Up Pending NHS Permissionnot specifiedNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 NICaS device in Herceptin patients - PHASE I, version 1.0_28/09/2015 - The accuracy, efficacy and reproducibility of the whole body bio-impedance in cardiac output monitoring in Herceptin patients using a Non Invasive Cardiac output monitoring System (NICaS) - PHASE I   
 Observational study: effect of Pirfenidone on cough in IPF patients - Observational study of the effect of Pirfenidone on cough in patients  with idiopathic pulmonary fibrosisIn Set-Up Pending NHS PermissionObservationalNo
 Oncogeriatrics Evaluation - National evaluation of oncogeriatrics assessment methodology and deliveryIn Set-Up Pending NHS Permission  
 Optimisation of neonatal ventilation - Optimisation of neonatal ventilation - determining the appropriate level of volume guarantee   
 Oxford Telehealth Qualitative Study version 1.2 - The Oxford Telehealth Qualitative Study (Case 3 in the SCALS - Studies in Co-creating Assisted Living Solutions - study).   
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Partnership in Prostate Cancer Care: (ICARE-P) - Partnership in Prostate Cancer Care: the feasibility of an integrated system to improve patient outcomes and experience (ICARE-P)   
 PHARLAP, protocol version 8uk - A multi-centre randomized controlled trial of an Open lung Strategy including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in patients with acute respiratory distress syndrome   
 Phase I Tracheal replacement using tracheal scaffold and MSC's - A Phase I open-label study to assess the safety, tolerability and potential efficacy of a novel tracheal replacement consisting of a tissue engineered de-celluarised tracheal scaffold with seeded autologous mesenchymal stem cells in subjects with severe tracheal stenosis or malacia   
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Physician associates in secondary care - Investigating the contribution of physician associates (PAs) to secondary care in England: comparative case studies   
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 Pre box change LV function screening - Evaluation of Screening Tools to Assess suitability for Resynchronisation Therapy Patients undergoing Pacemaker generator replaceMent (ESTARTPPM): Studies to evaluate the role of several screening tests for left ventricular dysfunction in patients scheduled for pacemaker generator box change to evaluate if upgrade to cardiac resynchronisation therapy may be appropriate.In Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predictors of progression from MCI to AD - Predictors of progression from mild cognitive impairment to dementia: brain functional network studiesIn Set-Up Pending HRA Approval  
 Pre-Hospital Brain Scanning - Pre-Hospital Brain Imaging - Evaluation of a Near InfraRed TechniqueIn Set-Up Pending HRA ApprovalObservational 
 Pre-Hospital Emergency Department Data Linking Project (PHED Data) 0.1 - Data linkage across ambulance services and acute trusts: assessing  the potential for improving patient care.In Set-Up Pending HRA ApprovalObservationalYes, within lead country only
 Prevalence of Pompe’s disease in respiratory clinics - Prevalence of Pompe’s disease amongst patients with unexplained  respiratory muscle weakness or respiratory failure   
 Primary care treatment of pain-related insomnia - Primary care treatment of pain-related insomnia: A feasibility study of a hybrid cognitive-behavioural approach   
 Priorities and Preferences for Whole Genome Sequencing - A study to define patient priorities and preferences when consenting to whole genome sequencing to ensure informed choiceIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Pro­-Euro­-DILI Registry version 1 - Prospective European DILI registry: Creation of a multicentre and  multidisciplinary European registry of prospective drug-induced liver injury cases.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Progression Evaluation in Glaucoma (PEG) - Progression Evaluation in Glaucoma (PEG): Progression of disease in patients newly diagnosed with glaucoma and glaucoma suspects  participating in the GATE studyIn Set-Up Pending NHS PermissionObservationalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 Qualitative Evaluation of Telephone Outreach for NHS Health Checks - Qualitative evaluation of telephone outreach to enhance uptake of NHS Health Checks in more deprived communities   
 Quality of life in glaucoma patients undergoing glaucoma surgery - Quality of Life assessment in glaucoma patients undergoing glaucoma surgery   
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR) - Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR)  Development of a rapid Point of Care Molecular assay for the  detection of carbapenem resistance genes in rectal swabsIn Set-Up Pending NHS PermissionInterventionalNo
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?In Set-Up Pending NHS PermissionObservational 
 ReGROUP: Retaining the experienced GP workforce in direct patient care - The changing general practitioner workforce: the development of policies and strategies aimed at retaining experienced GPs and those taking a career break in direct patient care (ReGROUP).In Set-Up Pending HRA ApprovalObservational 
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 REVEAL version 1 - Molecular profiling of tumour tissue, circulating nucleic acids and circulating tumour cells in early stage breast cancer.   
 RHiNO - Respiratory health outcomes in neonates   
 Role of avastin and 5-fluorouracil in trabeculectomy surgery (RAFTS) - The use of bevacizumab as a modulator of wound healing following trabeculectomy surgery: A Single Centre Randomised Controlled Phase III Pilot Study.   
 Safetxt: a randomised controlled trial of a safer sex intervention - Safetxt: A randomised controlled trial of an intervention delivered by mobile phone messaging to reduce sexually transmitted infections (STI) by increasing sexual health precaution behaviours in young peopleIn Set-Up Pending HRA ApprovalInterventionalYes, within lead country only
 SERINE PROTEASES AND SERPINS IN DUCHENNE MUSCULAR DYSTROPHY - SERINE PROTEASE AND SERPIN LEVELS AND ACTIVITY IN CHILDREN WITH DUCHENNE MUSCULAR DYSTROPHY   
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Sirolimus Treatment for PIK3CA Related Overgrowth (PROMISE) - A Non-Randomised, Open Label, Pilot Trial of Sirolimus Therapy for Segmental Overgrowth Due to PIK3CA Related Overgrowth   
 Skin Camouflage for Women Prisoners with Self-Harm Scarring: Version 2 - Feasibility and Acceptability of Medical Skin Camouflage for Recovery of Women with Self-Harm Scarring in Prison: Phase 1 and 2In Set-Up Pending HRA Approval  
 Sleep and Psoriasis survey - What is the frequency and nature of sleep disruption in a sample of people with psoriasis?In Set-Up Pending NHS PermissionObservationalNo
 Sleep and Psoriasis Qualitative Study - Exploring sleep experiences of people living with psoriasis   
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Social Inclusion in Mental Health - Development and Validation of a measure of Social Inclusion ­ The SInQUEIn Set-Up Pending HRA Approval  
 Specificity of "4 Mountains" spatial memory test for Alzheimer disease - The 4 Mountains Test of spatial memory for diagnosis of early Alzheimer's disease: evaluation of diagnostic specificity.   
 Spectral Analysis of Brain Tissue at Operation - (HELICoiD B) - Spectral Analysis of Brain Tissue at Operation - HypErspectraL Imaging Cancer Detection BIn Set-Up Pending HRA Approval  
 SPREE (version 1.0) - Screening programme for pre-eclampsiaIn Set-Up Pending HRA ApprovalObservationalYes, within lead country only
 StOP Haemophilia A Study - Strategies for Optimising Prophylaxis – Clinical Utility and Accuracy of Model Predicted Factor VIII half­life and Trough Levels Compared to Current Recommended Prophylaxis Monitoring Strategies in Routine Clinical Practice in Adult Haemophilia A – StOP Haem A Study   
 STOP-HCV-1 version 1.0 - Stratified Treatment OPtimisation for HCV-1 (STOPHCV-1)   
 STRAT-­PD - Identification of biological indicators for disease in patients with Parkinson’s disease – The Breath Test StudyIn Set-Up Pending HRA ApprovalObservationalNo
 STUDY TO BE DELETED - STUDY TO BE DELETEDIn Set-Up Pending HRA Approval  
 Taking pART: How people decide to consent for fertility research - Taking pART: Understanding how patients decide whether to consent to the use of fertility data for research - A qualitative study of patients undergoing treatment and the staff who explain consent proceduresIn Set-Up NHS Permission Received  
 TASTE - Tenecteplase versus Alteplase - Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial   
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up NHS Permission ReceivedInterventional 
 Telehealth for patients living with COPD and co­-existing conditions - Telehealth for patients living with COPD and co­existing conditions: experiences of healthcare and implications for the design of acceptable and appropriate home­-based telehealth systems   
 TEPHRA Version 1 - Trial of Exercise to Prevent Hypertension in Young Adults   
 testCW - should be ignored/deleted   
 The British Orthopaedic Surgery Surveillance Study - The BOSS Study. - The British Orthopaedic Surgery Surveillance Study: A nationwide service evaluation, and nested-cohort study.   
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The TREatment of severe Atopic eczema Trial (TREAT) - A Randomised Controlled Trial Assessing the Effectiveness, Safety and Cost-effectiveness of Methotrexate versus Ciclosporin in the Treatment of Severe Atopic Eczema in Children: The TREatment of Severe Atopic Eczema Trial (TREAT)In Set-Up Pending NHS PermissionInterventional 
 The DESiGN Trial ­ Detection of small for gestational age fetus (SGA) - The DESiGN Trial ­ Detection of small for gestational age fetus (SGA) – a cluster randomised controlled trial to  evaluate the effect of the Growth Assessment Protocol (GAP) programmeIn Set-Up Pending NHS PermissionInterventionalYes, within and outside lead country
 The PReSUTINeB Study (v1.0). - Prevention of Recurrent Symptomatic Urinary Tract Infections in Patients with Chronic Neurogenic Bladder Dysfunction: A mixed Method Study (The PReSUTINeB Study).   
 'Together’ promotion of healthy lifestyles - 'Together’ a European project related to the promotion of healthy  lifestyles to pregnant and lactating women.In Set-Up Pending NHS PermissionObservationalNo
 TRIGGER Trial - Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker to Stratify Management of Good And Poor Responders To Chemoradiotherapy: A Rectal Cancer Multicentre Randomised Control Trial   
 TROLLEY - Evaluation of a growth guiding construct vs. standard dual growing  rods and VEPTR for the treatment of early onset  scoliosis patients: A prospective multi­center cohort study with a matched historical control.   
 UK STAR - UK Study of tendo Achilles Rehabilitation - multicentre randomised clinical trial   
 UltraSound Evaluation For mUsculoskeletal Lupus (USEFUL) - A prospective observational study to investigate the validity of ultrasound as an outcome measure in assessing response to therapy in Systemic lupus erythematosus (SLE)In Set-Up Pending HRA ApprovalObservational 
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vestibular Function in Patients with Vestibular Schwannoma - Vestibular Function in Patients with Vestibular Schwannoma (Acoustic Neuroma)   
 Visual processing patterns in neurodevelopmental disorders - Visual processing patterns in neurodevelopmental disordersOpenObservational 
 Visual Field Algorithm Study (vFAST) - Quantification of agreement and variability characteristics of a newly developed visual field algorithm with the reference standard: an observational study   
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 What can gait analysis tell us about dementia and its subtypes? - What can gait analysis tell us about dementia and its subtypes? An integrated study of brain and behavior.   
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 WHIST - Wound Healing In Surgery for Trauma - WHIST - Wound Healing In Surgery for Trauma. A Randomised Controlled Trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients having surgical incisions for major trauma to the lower limbIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 WHiTE Four - World Hip Trauma Evaluation Four: A randomised controlled trial of the sliding hip screw versus X­Bolt dynamic plating system for the fixation of trochanteric fractures of the hip.   
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 Whole-­genome sequencing of multidrug-­resistant organisms in ICU - Whole-genome sequencing to investigate colonisation and transmission of  multidrug-­resistant organisms on the  adult intensive care unit at Addenbrooke’s HospitalIn Set-Up Pending NHS PermissionObservationalNo
 Xenon lung imaging in COPD: a COPD Cohort substudy - Hyperpolarised xenon magnetic resonance imaging (Xe-129 MRI) lung imaging in COPDIn Set-Up NHS Permission ReceivedObservationalNo




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