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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A feasibility study of treatments for Dupuytren's Contracture - Needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren’s contractures of the fingers: a feasibility study which investigates the acceptability and design of a multicentre randomised controlled trial (RCT).In Set-Up Pending NHS PermissionObservationalNo
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A study to evaluate the effect of solithromycin in COPD - A singlecentre, doubleblind, randomised, placebo-controlled, crossover study to evaluate the effect of solithromycin on airway inflammation in male and female patients with chronic obstructive pulmonary disease.In Set-Up Pending NHS PermissionObservationalNo
 ADDITION Plus - 10 year - ADDITION Plus - 10 year   
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Adult onset type 1 - diabetes ­ the PROCEED study - An Exploratory Study to Develop a Supportive Programme of Care for Adult Onset - Type 1 Diabetes­ the PROCEED study.   
 ALSCarE - A Programme for ALS Care in Europe (ALSCarE)OpenObservationalNo
 AMPSIM - A pilot study to compare Virtual Reality (VR) versus VR plus haptic feedback as a possible technique to decrease phantom pain responses in amputeesIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 An investigation into distractibility in those reporting memory change - Attention all!: An investigation into distractibility in everyday lifeIn Set-Up NHS Permission ReceivedObservationalNo
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Antiplatelet therapy in COPD (APPLE-COPD:ICON 2) - Anti-platelet Therapy in the Primary Prevention of Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease.In Set-Up Pending NHS PermissionObservationalNo
 Attachment and mentalization as predictors of family therapy outcome - Attachment and mentalization as predictors of outcome in family therapy for adolescent anorexia nervosaIn Set-Up Pending NHS PermissionObservationalNo
 Baby Express Research Trial - First Year Together: Evaluation of Baby Express in Greater ManchesterIn Set-Up Pending NHS PermissionObservationalNo
 Benefit and Risk Information for Medication in Multiple Sclerosis (BRIMMS) - Improving understanding and recall of risk information relating to MS medication: Developing an evidence-based clinical tool for assisting communication and understanding of MS medication risk information between patients and health professionals Benefit and Risk information for Medication in Multiple Sclerosis (BRIMMS)In Set-Up NHS Permission ReceivedObservationalNo
 Bleeding disorders in women undergoing surgery for menorrhagia - Disorders of Platelet Function and Coagulation in Women Undergoing Surgical Intervention for Severe MenorrhagiaIn Set-Up Pending NHS PermissionObservationalNo
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Breath Analysis in ICU for Diagnosis of Ventilator Associated Pneumonia - Breath Analysis in Intensive Care: Proof of Concept for Non-Invasive Diagnosis of Ventilator Associated PneumoniaIn Set-Up Pending NHS PermissionObservationalNo
 CapaCiTY Study 2 - Chronic Constipation Treatment Pathway - PRAGMATIC RANDOMISED TRIAL OF LOW VERSUS HIGH VOLUME INITIATED TRANSANAL IRRIGATION THERAPY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventionalNo
 CapaCiTY Study 3-Chronic Cinstipation Treatment Pathway - STEPPED WEDGE RANDOMISED TRIAL OF LAPAROSCOPIC VENTRAL MESH RECTOPEXY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 Care Homes Independent Pharmacist Prescribing Service: CHIPPS - WP4 - Care Homes Independent Pharmacist Prescribing Service (CHIPPS): Development and delivery of a cluster randomised controlled trial to determine both its effectiveness and cost-effectiveness; Work Package 4In Set-Up Pending NHS Permission  
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Communication and Dementia Version 1.0 - Communication and Dementia Version 1.0In Set-Up Pending NHS PermissionObservationalNo
 Comparison of Ostomy Products (COOP) - A randomised-controlled double-blind crossover comparison of Manuka honey hydrocolloid (Aurum®) versus conventional hydrocolloid (Optum®) on peristomal skin health.In Set-Up Pending NHS PermissionObservationalNo
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 CUTHIVAC002 - A Phase I clinical trial to assess the safety and immunogenicity of HIV DNAC CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteersIn Set-Up Pending NHS PermissionObservationalNo
 DECIDE and SHARE-IT: shared decision making - Development of generic decision aids linked to recommendations in GRADE guidelines to promote shared decision making in the clinical encounter: user-testing and feedbackIn Set-Up Pending NHS Permission  
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a PROM for Cardiac Rehabilitation - Development of a Patient-reported Outcome measure (PROM) for Cardiac RehabilitationIn Set-Up Pending NHS PermissionInterventionalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Dex - CSDH Trial - A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematomaIn Set-Up Pending NHS PermissionInterventionalNo
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diabetic Foot Ulcer Prevention System (DFUPS) - An Innovative System for the Early Identification, Monitoring, Evaluation and Diagnosis of Diabetic Foot Ulcers   
 Diagnosing and monitoring infection in critical illness - Diagnosing and monitoring infection in critically ill patients using metabolic and immunological signaturesIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 ERUK - ERUK - Established and novel cell-surface autoantibodies in adults with new-onset cryptogenic epilepsiesOpenObservationalNo
 Evaluation Of Patient Organiser For Patients with IPF - PILOTING OF AN IDIOPATHIC PULMONARY FIBROSIS (IPF) ORGANISEROpen No
 Extending Working Lives in the NHS version 1Extending Working Lives in the NHS version 1 - Extending Working Lives in the NHS: Opportunities, Challenges and ProspectsIn Set-Up Pending NHS Permission  
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 GARMIN-II: double-blind randomised controlled trial of lesogaberan in cough - The Role of GABAb receptor mechanisms in cough: Double-blind randomised controlled trial of Lesogaberan in Chronic cough patients with positive and negative symptom association probabilitiesIn Set-Up Pending NHS PermissionInterventionalNo
 Genes and the Kidney in Tuberous Sclerosis - A Study of the Natural History of Renal Disease in TSC2/PKD1 Contiguous Gene Deletion Syndrome.OpenObservationalNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENFI sub-study - GENFI sub-studyIn Set-Up Pending NHS PermissionObservational 
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 Gut bacteria in colorectal cancer - Role of toxigenic bacterial infections in cancer developmentIn Set-Up Pending NHS Permissionnot specifiedNo
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 Hypoxia gene signature as a biomarker in prostate cancer - Development and validation of a hypoxia gene signature as a biomarker of radioresistance in prostate cancerIn Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Innovate Dementia Acorn Project - An evaluation of the impact of intelligent lighting in an in-patient environment for people living with dementiaIn Set-Up Pending NHS PermissionObservational 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 INSPIRE. - A prospective*, randomised, Interventional Study evaluating the short-term PredIction of Pre-eclampsia/Eclampsia in pregnant women with suspected pre-eclampsia.In Set-Up Pending NHS PermissionObservationalNo
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating Pain Mechanisms in Endometriosis Version - Investigating pain mechanisms in endometriosis: a multimodal study to identify mechanisms and markers of central and inflammatory pain in women with endometriosis.In Set-Up Pending NHS PermissionObservationalNo
 Kidney Injury after Major Surgery (KIMS) - Observational study of the long term outcomes of acute kidney injury after major surgeryIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 LAIV and EHPC - The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage StudyIn Set-Up Pending NHS PermissionObservationalNo
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 LOCATE - LOCATE: Localising Occult prostate Cancer metastases with Advanced imaging TEchniqueIn Set-Up Pending NHS PermissionObservational 
 Long term abdominal drains in end stage cirrhosis - Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis : a feasibility randomised controlled trial.In Set-Up Pending NHS PermissionObservationalNo
 LOTUS Study - Dynamic Lycra Orthoses as an adjunct to upper limb rehabilitation after stroke: A feasibility study and trial.In Set-Up Pending NHS PermissionInterventionalNo
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Metabolomics in SLE - Pilot study on the use of metabolomics to predict outcome in patients with systemic lupus erythematosusIn Set-Up Pending NHS PermissionObservationalNo
 Methotrexate induced liver fibrosis - Evaluation of the role of AST:ALT ratio, ELF markers and fibroscan in the detection of methotrexate induced hepatotoxicity.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 mHealth for antenatal mental health - Tablet computers for implementing NICE antenatal mental health guidelines Feasibility studyIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Molecular Imaging of Multiple Sclerosis (MIMS) - Molecular Imaging of Tissue Structure and Metabolism In Multiple SclerosisIn Set-Up Pending NHS PermissionInterventionalNo
 Mood mAPPer - Mood mAPPer: Validation of a Mobile Phone App to track Moods and Mental States in Young Persons with ADHDIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 MRI cardiopulmonary metrics in pulmonary arterial hypertension - Reproducibility of Magnetic resonance imaging cardiopulmonary metrics in healthy volunteers and patients with pulmonary arterial hypertension – Implications for trial design   
 Multimodality imaging of the aorta - Investigation into aortic structure and function using magnetic resonance imaging (MRI), computed tomography (CT) and position emission tomography (PET)In Set-Up Pending NHS Permission  
 NMDA PET in TBI - Imaging NMDA receptor activation following head injury using positron emission tomographyIn Set-Up Pending NHS PermissionObservationalNo
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke SurvivorsIn Set-Up Pending NHS Permission  
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patients' views of discussing weight management with knee OA V1.15.1.15 - To understand patients’ views and experiences of discussing weight management with a health professional when they have a clinical diagnosis of knee osteoarthritis and a BMI of over 25.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Perceptions of pilot ward staff involved in PRASE - The PRASE Intervention in collaboration with hospital volunteers: Exploring the perceptions of ward staff involved in receiving and acting upon patient feedback.In Set-Up Pending NHS Permission  
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PhenoDM1 - Myotonic Dystrophy type 1 (DM1) deep phenotyping to improve delivery of personalised medicine and assist in the planning, design and recruitment of clinical trials.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Physiotherapy in Conservatively Managed Distal Radius Fractures - Outcomes and Cost Effectiveness of Physiotherapy, Self Directed Therapy and Advice Sheets Following Conservatively Managed Distal Radius Fractures : A Prospective Randomised Controlled Trial.In Set-Up Pending NHS PermissionObservationalNo
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 PLACE Qualitative Sub-Study - PLACE (Prevention of Lymphoedema after Clearance by External Compression) Qualitative Sub-StudyIn Set-Up Pending NHS Permission  
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predicting poor outcome following total hip and knee arthroplasty - A prospective observational (C) study in adult patients with primary osteoarthritis (P), to identify the physical and psychological risk factors predicting poor patient satisfaction and function (O) following primary total hip and knee arthroplasty (I) I ­Intervention, P ­Population,  O Outcome, C ­ ComparatorOpenObservationalNo
 Predictors of outcome in vein of Galen malformation - Identifying early predictors of outcome in neonatal vein of Galen malformation.In Set-Up Pending NHS PermissionInterventional 
46012373Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 PRIM4641 - A method validation, single-period, open-label evaluation study to explore the sensitivity of a novel biosensor device (SenseWear® Armband Gecko) for measuring physical activity in subjects with COPD & AsthmaIn Set-Up Pending NHS Permission  
 PRINCESS - Prehospital Resuscitation IntraNasal Cooling Effectiveness Survival Study (PRINCESS)In Set-Up NHS Permission ReceivedInterventionalNo
 Protein defects in retinal degenerations (version 0.9) - Investigation of protein defects in inherited retinal degenerationsIn Set-Up Pending NHS PermissionObservationalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Realist Evaluation of Adapted Sex Offender Treatment Programs - Realist Evaluation of Adapted Sex Offender Treatment Programs for Men with Intellectual DisabilityIn Set-Up Pending NHS PermissionObservationalNo
 Reduced Appetite in Crohn’s disease - Reduced Appetite in Crohn’s disease: The role of the brain in the control of food intakeIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?In Set-Up Pending NHS PermissionObservational 
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Repurposing anti-TNF for treating Dupuytren's disease - A multicentre, double blind, randomised, placebocontrolled, parallel group, phase II trial to determine the safety and efficacy of intranodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with a dose response run-in.In Set-Up Pending NHS PermissionObservationalNo
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Retention of CD16+ monocytes in the ischaemic limb - The Retention of Angiogenic CD16+ Monocytes in Critical Limb Ischaemia (ROAM­CLI)   
 RIVER Registry – RIVaroxaban Evaluation in Real life setting - Prospective, multicentre, international Registry of male and female patients newly diagnosed with Atrial Fibrillation and treated with  Rivaroxaban   
 Rowing Away from Diabetes - Indoor rowing in adults with impaired glucose regulation: a pilot study   
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 ShoulderLink - Acceptability of real time 1:1 videoconferencing consultations after shoulder rehabilitationIn Set-Up Pending NHS PermissionObservationalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 SILKIE (Skin graftIng Low friKtIon Environment) - Can skin grafting success rates in burn patients be improved by using a low friction environment – a feasibility study?In Set-Up Pending NHS PermissionObservationalNo
 Simvastatin in sight threatening Uveitis trial (SU) - Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial.In Set-Up Pending NHS PermissionInterventionalNo
 Skills for weight loss Maintenance (SkiM) - Skills for weight loss Maintenance (SkiM): The feasibility of an intervention to support weight loss maintenance, and of a trial to evaluate itIn Set-Up Pending NHS Permission  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Study of the effects of Vitamin D on immune responses to Tuberculosis - Study of the effects of Vitamin D on immune responses to Tuberculosis.In Set-Up Pending NHS Permissionnot specifiedNo
 Surgery and Alzheimer's pathology - Evaluating the influence of obesity on neuroinflammation and Alzheimer’s pathologyIn Set-Up Pending NHS PermissionObservationalNo
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 TB040: MVA85A aerosol vs IM in adults with latent M.tb infection - A phase I trial to compare the safety and immunogenicity of candidate TB vaccine MVA85A administered by the aerosol inhaled route and the intramuscular route in healthy adult volunteers who are latently infected with Mycobacterium tuberculosisIn Set-Up Pending NHS PermissionObservationalNo
 The effect of oxytocin on conduct disorder & Autism Spectrum Disorder - The effect of intranasal oxytocin on the brain processing of antisocial adolescents with a diagnosis of conduct disorder or autism spectrum disorder, compared to healthy controlsIn Set-Up Pending NHS PermissionInterventionalNo
 The effect of oxytocin on psychopathy and Autism Spectrum Disorder - The effect of intranasal oxytocin on the brain processing of adult subjects with a diagnosis of antisocial personality disorder and criminal psychopathy, or autism spectrum disorder, compared to healthy controlsIn Set-Up Pending NHS PermissionInterventionalNo
 The in vivo migration and micromotion of the TriFit TS femoral stem - Investigation of the invivo migration and micromotion in the Corin TriFit TS femoral hip system using Radiostereometric Analysis (RSA)In Set-Up Pending NHS PermissionObservationalNo
 The INFECIR2 Albumin Prevention Study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.In Set-Up Pending NHS PermissionObservationalNo
 The PRACTICE Trial - Pulmonary Rehabilitation and ACTIvity after COPD Exacerbation - The PRACTICE TrialIn Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 Transitions from paediatric to adult services for sickle cell disease - Transitions from paediatric to adult services for sickle cell disease (SCD): a prospective qualitative study examining young adult patients’ experiencesIn Set-Up Pending NHS PermissionObservationalNo
 UK-PK Study - National Study of the Implementation of a Pharmacokinetic Focused Educational Package for patients living with Severe Haemophilia A.In Set-Up Pending NHS PermissionObservationalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validating the MSKHQ - Validating the Arthritis Research UK Musculoskeletal Health Questionnaire (MSKHQ).In Set-Up Pending NHS PermissionObservationalNo
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vascular Function in Obesity - Identification of cardiovascular changes in obesity using dynamic and static retinal vessel analysisIn Set-Up Pending NHS PermissionObservationalNo
 Vibrant Effectiveness and Reliability Study (VERS) - Evaluating the long-term reliability and performance of the Vibrant Soundbridge and Bonebridge systemsIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Vision On: HAI training tool - Vision-on: Staff Training Tool for the Prevention of Healthcare Associated InfectionsOpenObservationalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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