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Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ABPA. - Studies on Aspergillus Lung DiseaseIn Set-Up Pending NHS PermissionObservationalNo
 Acceptability of a PA intervention for managing RA fatigue Version 1 - Managing fatigue in rheumatoid arthritis (RA) with physical activity (PA) (FRAPA). Phase 3: Exploring the acceptability of a physical activity interventionIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 ACES Art as Creative Engagement for Stroke - Can an arts based creative engagement intervention following stroke improve psychosocial outcomes? A feasibility trial of a creative engagement intervention for in-patient rehabilitationIn Set-Up Pending NHS Permission  
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Analysis of 24/7 working in the London hyper acute stroke system - Analysis of 24/7 working in the London hyper acute stroke systemIn Set-Up Pending NHS Permission  
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Beyond TME - The role of MRI in improving surgical technique and outcomes in exenterative pelvic surgery for locally extensive primary or recurrent rectal cancerIn Set-Up Pending NHS PermissionInterventional 
 Biomarker identification in lymphoproliferative disorders - The identification of clinically relevant biomarkers in lymphoproliferative disordersIn Set-Up Pending NHS PermissionObservational 
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Body composition & chemo response & toxicity in early breast cancer - CANDO-2: A feasibility and pilot cohort study to investigate body composition and chemotherapy response and toxicity in early breast cancerIn Set-Up Pending NHS Permission  
41349358BreatheMORHF: Morphine for breathlessness in heart failure Version 1 - A parallel group, double-blind, randomised placebo-controlled trial comparing the efficacy and cost-effectiveness of 20mg daily oral modified release morphine (MRM) versus placebo on the intensity of dyspnoea in patients with stable symptomatic chronic heart failure (CHF)In Set-Up Pending NHS PermissionInterventional 
 Can aldosterone predict sinus after treatment of AF? - Does aldosterone predict maintenance of normal sinus rhythm after treatment of atrial fibrillation?   
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 Dapagliflozin in Type 2 diabetic patients with diabetic nephropathy - A study to investigate the potential renoprotective role of sodium-glucose transporter-2 (SGLT2) antagonist Dapagliflozin in Type 2 diabetic patients with diabetic nephropathyIn Set-Up Pending NHS Permission  
 Dementia in the workplace - Dementia in the workplace: a feasbility study exploring the employment related experiences of people with dementia or mild cognitive impairment and their employers and coworkers to identify the potential for continued employment postdiagnosisOpenObservationalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityIn Set-Up Pending NHS Permission  
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 DREAM GLP-1 Study - Diastolic RV EvAluation with Millar catheter to investigate the effect of Glucagon-Like Peptide-1 (GLP-1) on right ventricular function during elective coronary angioplasty and stenting DREAM-GLP1   
 DRN 900 - study diabetesIn Set-Up Pending NHS PermissionObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 ECLIPSE: Exploring the Current Landscape of IV Infusion Practices v.1 - Exploring the Current Landscape of Intravenous Infusion Practices and Errors (ECLIPSE)In Set-Up Pending NHS Permission  
 EORTC 90091-10093 - Trastuzumab in HER2-negative Early breast cancer as Adjuvant Treatment for Circulating Tumour Cells (CTC) ("Treat CTC" trial)In Set-Up Pending NHS Permission  
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 EORTC Oral Health Module - Phase 4 International Field Testing - International validation and testing of a supplementary module to the EORTC QLQ-C30 for assessment of oral and dental health in cancer: the QLQ-OH17In Set-Up Pending NHS PermissionObservational 
 EORTC QL Cut-Off Scores - Development of cut-off scores for symptom screening with the EORTC quality of life scales and evaluation of graphical presentation styles for quality of life results including these cut-offsIn Set-Up Pending NHS PermissionObservational 
 EORTC Quality of Life Module for patients with vulva cancer - Phase 3-4 development of a questionnaire to address treatment morbidity and assess the quality of life following treatment for vulva cancerIn Set-Up Pending NHS PermissionObservational 
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 EQUALIOHEXOL study - The European Quality Study on treatment in advanced chronic kidney disease: iohexol substudy   
 eRAPID RCT in systemic cancer treatment - eRAPID Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice: Randomised controlled trial in systemic cancer treatmentIn Set-Up Pending NHS PermissionInterventional 
 Evaluating outcomes of immediate breast reconstruction (POBRAD-M) - Prospective, multicentre, observational trial evaluating outcomes of immediate breast reconstruction using an implant and acellular dermal matrix (SurgiMend PRS) or autologous tissueIn Set-Up Pending NHS PermissionObservational 
 Exploring views of hospital volunteers collecting patient feedback - Exploring the views of hospital volunteers involved in collecting patient feedbackIn Set-Up Pending NHS Permissionnot specified 
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 FLAIR: Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab - FLAIR: Front-Line therapy in CLL: Assessment of Ibrutinib + RituximabIn Set-Up Pending NHS PermissionInterventional 
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitation   
 Follow up protocol to the Opsona OPN305-102 study - A Three-Part, Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Sequential Adaptive, Phase II Study to Evaluate the Safety, Tolerability and Efficacy of OPN-305, a Humanised Monoclonal Antibody that Blocks Toll-Like Receptor 2, in Renal Transplant Patients at High Risk of Delayed Graft FunctionIn Set-Up Pending NHS Permission  
 Frailty in older adults living with HIV version - A prospective, observational study to examine frailty prevalence and predictors in an HIV-infected population aged 50 years and over in the South East of EnglandIn Set-Up Pending NHS PermissionObservationalNo
 Functional Outcomes Following Anal Cancer Treatment (FOFACT) - Functional Outcomes Following Anal Cancer Treatment (FOFACT)In Set-Up Pending NHS PermissionObservational 
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Gene Therapy in Heart Failure: A Qualitative Interview Study - The Views and Experiences of Patients, their families, the Public and Healthcare Professionals’ on the use of Gene Therapy in the management of Heart Failure.   
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENPROS. - GENPROS - Analysing outcomes after prostate cancer diagnosis and treatment in carriers of rare germline mutations in cancer predisposition genesIn Set-Up Pending NHS PermissionObservational 
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 HCMR Study - HCMR - Novel Predictors of Outcome in Hypertrophic CardiomyopathyIn Set-Up Pending NHS PermissionInterventionalNo
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hyperoxaemia - Myocardial Perfusion and Microvascular Dysfunction in Stable Coronary Artery Disease During Hyperoxaemia   
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Imaging Amyloidosis with PET/MRI - Imaging Cardiac and Systemic Amyloidosis using 18F-Florbetapir Positron Emission Tomography (PET), relationship with Magnetic Resonance imaging (MRI) using simultaneous hybrid PET/MRI; a pilot studyIn Set-Up Pending NHS PermissionObservational 
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 IMMUNOTACE - A randomised phase II clinical trial of conditioning cyclophosphamide and chemoembolisation with or without vaccination with dendritic Cells pulsed with HepG2 lysate in vivo in patients with Hepatocellular CarcinomaIn Set-Up Pending NHS PermissionInterventional 
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Integrative care pathway for patients with MUS - Innovative and integrative care pathway for patients with MUS (Medically Unexplained Symptoms) conditions in primary care mental health liaison servicesIn Set-Up Pending NHS PermissionObservational-unknown-
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Leg oedema In Multiple Sclerosis (LIMS) Version 1.0 - Chronic lower limb oedema in people with multiple sclerosis: prevalence, precipitating factors and secondary consequencesIn Set-Up Pending NHS PermissionObservationalNo
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Marine enzymes as a novel method of biofilm control - Marine enzymes as a novel method of biofilm controlIn Set-Up Pending NHS Permission  
 Mechanisms of Exercise Benefit with IV Iron in CHF ver 8 - Mechanisms of Exercise Benefit with Intravenous Iron in Chronic Heart Failure: The Ferric Iron in Heart Failure (FERRICHF) II Trial   
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Modelling retinal disease mechanisms and ocular cell development - Modelling retinal disease mechanisms and ocular cell development using induced pluripotent stem cellsIn Set-Up Pending NHS PermissionObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Msk Evaluation - Evaluation of the redesigned NHS Lanarkshire Musculoskeletal Service   
 Online CBT for Type 1 diabetes - The ‘Diabetes with Online Therapy’ Study (DOT): A feasibility study of the effectiveness of online cognitive behavioural therapy (CBT) for improving glycaemic control for people with type 1 diabetes   
 On-line self-management after treatment for prostate cancer - 'Getting Down to Coping' On-line self-management after treatment for prostate cancer: a feasibility studyIn Set-Up Pending NHS Permission  
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PaMIR: Parkinson’s Magnetic Resonance Imaging Research:Part 1 - PaMIR: Parkinson’s Magnetic Resonance Imaging Research: Part 1 – Multicentre MRI study in Parkinson’s diseaseIn Set-Up Pending NHS PermissionObservational 
 Phase Ib trial of Atu027 in HNSCC - Phase Ib trial of Atu027 in Combination With Cisplatin, 5FU and Cetuximab in Patients With Head and Neck CancerIn Set-Up Pending NHS Permission  
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PICTURE BREAST XS (cross-sectional) - PICTURE Breast XS: Patient Information Combined for local Therapy oUtcome assessment in bREast cancer cross-sectionalIn Set-Up Pending NHS Permission  
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 Quantitative test of the resynchronization hypothesis for CRT - Quantitative test of the resynchronization hypothesis with development of tools for haemodynamic optimization and response quantification   
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 redi: Risk-assessed Exercise & Diet Intervention - Stage 1 - redi: Risk-assessed Exercise and Diet Intervention for men with prostate cancer: Stage I - Proof of conceptIn Set-Up Pending NHS Permission  
 Renal denervation effects in patients with chronic kidney disease - Effects of renal denervation on renal function in patients with chronic kidney disease   
 Resources for Living (R4L) Pilot - Resources for Living (R4L) Pilot: Exploring the Potential of Progressive Cuisine for Quality of Life Improvement for Head and Cancer SurvivorsIn Set-Up Pending NHS PermissionObservational 
 Respiratory and peripheral muscle function in people with lung cancer - Respiratory and peripheral muscle function in people with lung cancerIn Set-Up Pending NHS Permission  
 Retinal photography in older HIV positive adults - Using retinal photography to estimate cerebrovascular and cardiovascular health in HIV positive adults aged over fifty, HIV negative controls aged over fifty, and younger HIV positive adultsIn Set-Up Pending NHS PermissionObservational 
 RIOPRED - Riociguat in patients with respiratory disease and hypoxia – a proof-of-concept studyIn Set-Up Pending NHS PermissionObservationalNo
 SERENADE - SERENADE: Screening for synchronous metastases in colorectal cancer using Hepatic Diffusion weighted MRI.In Set-Up Pending NHS PermissionInterventional 
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Telehealth in Motor Neurone Disease - Telehealth in Motor Neurone Disease: A single centre, randomised controlled feasibility and pilot study of the use of the TiM telehealth system to deliver highly specialised care in Motor Neurone Disease, at a distance.In Set-Up Pending NHS PermissionInterventionalNo
 Testing a new stepwise strategy for the management of renal anaemia - Testing a new stepwise strategy for the management of renal anaemia in primary care: An exploratory cluster randomised triaIn Set-Up Pending NHS Permission  
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The Glove Project - Generation and Evaluation of Hand Therapy Devices for Epidermolysis BullosaIn Set-Up Pending NHS PermissionObservationalNo
 The impact on patients of viewing their own 3D medical imaging result - The impact on patients and their health related decision making of viewing their own medical imaging results in the form of 3D accessible images.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 The PODD Study - The PODD Study: The PeriOdontal Disease and Diabetes Study: An opportunistic screening study   
 The Pulses Study - Pulsed glucocorticoid replacement therapy for patients with adrenocortical insufficiency secondary to Addison’s disease and congenital adrenal hyperplasiaIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The STAT-ROC Feasibility Study - A feasibility study of adjuvant STATin therapy in the prevention of postoperative Recurrence of Oesophageal adenoCarcinoma (The STATROC feasibility study)In Set-Up Pending NHS PermissionInterventional 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 TMS markers of plasticity in acute stroke - Characterising post stroke plasticity in humans: is there a critical window for enhancing neuroplasticity after stroke?In Set-Up Pending NHS PermissionInterventional 
 Trajectories of Outcome in Neurological Conditions Sub-Study 4 Longtitudinal - Trajectories of Outcome in Neurological Conditions: Quality of Life (QoL) and neurological disease Sub-Study4 LongtitudinalIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Trial Net Dried Blood Spot Substudy - Dried Blood Spot Substudy to Assess the Use of Dried Capillary Bloodspots for Initial Screening to Identify Individuals with Multiple Islet AutoantibodiesIn Set-Up Pending NHS Permission  
 TRIP - Testing in recreational settings prevention - interventions addressed to polydrug users - TRIP - Testing in recreational settings prevention - interventions addressed to polydrug usersClosedObservationalN/A
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods study   
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 Whole body PET-MRI in paediatric and adolescent Hodgkin Lymphoma - Feasibility of using whole body PET-MRI to stage and restage paediatric and adolescent lymphoma – a pilot study.In Set-Up Pending NHS Permission  




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