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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A clinical evaluation of a CVC securement device - A clinical evaluation of two central venous catheter stabilization systemsIn Set-Up Pending NHS PermissionInterventionalNo
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Abbreviated Mentalization Based Therapy in Borderline Crises(AMBIC) - A randomised controlled trial of community mentalization based therapy compared to treatment as usual in borderline personality disorder: a study of clinical outcome and cost effectivenessIn Set-Up Pending NHS PermissionInterventional 
 ACtiF Adherence to treatment in adults with Cystic Fibrosis 2.2B (1) - Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis (ACtiF)In Set-Up Pending NHS PermissionObservationalNo
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 ADSTEM - A phase I/II study to evaluate allogeneic mesenchymal stromal cells for the treatment of skin disease in adults with recessive dystrophic epidermolysis bullosa.In Set-Up Pending NHS PermissionObservationalNo
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 BronchUK Study - Observational cohort and Biobank UK StudyIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Calibre - CALiBRe: Assessment of the Mechanism of Action of idelalisi (CAL101) in B-cell Receptor Pathway Inhibition in CLLIn Set-Up Pending NHS Permission  
 CapaCiTY Study 2 - Chronic Constipation Treatment Pathway - PRAGMATIC RANDOMISED TRIAL OF LOW VERSUS HIGH VOLUME INITIATED TRANSANAL IRRIGATION THERAPY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventionalNo
 CapaCiTY Study 3-Chronic Cinstipation Treatment Pathway - STEPPED WEDGE RANDOMISED TRIAL OF LAPAROSCOPIC VENTRAL MESH RECTOPEXY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
 Caring for Me and You : cCBT for dementia carers - Can online Cognitive Behavioural Therapy lead to sustained improvement in mood and other key outcomes in people caring for individuals with dementia? A randomised controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 Case-control study for Campylobacter in the under 5s. Version 1 - Case-control study for Campylobacter in the under 5s.In Set-Up Pending NHS PermissionObservational 
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Cellular immunity to herpesvirus infection: Studies with EBV & CMV -v1 - Cellular immunity to herpesvirus infection: Studies with Epstein-Barr virus and human cytomegalovirusIn Set-Up Pending NHS PermissionObservationalNo
 Chronic neuroinflammation following blast TBI - Investigating chronic neuroinflammation and neurodegeneration following blast traumatic brain injury (bTBI) and its relationship to brain structure and functionIn Set-Up Pending NHS PermissionObservational 
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Clinical trial of wearable computer to improve visual field v4 - A pilot clinical trial of an augmented reality wearable computer to improve the visual field of monocular patientsIn Set-Up Pending NHS Permissionnot specifiedNo
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 CTC tumourgenicity in early stage NSCLC - Tumourigenicity of Circulating Tumour Cells in Early Stage Lung Cancer to Predict Disease RecurrenceIn Set-Up Pending NHS Permission No
 DECIDE and SHARE-IT: shared decision making - Development of generic decision aids linked to recommendations in GRADE guidelines to promote shared decision making in the clinical encounter: user-testing and feedback   
 Decision making in the management of recurrent tonsillitis - Decision making in adults referred to ENT for management of recurrent tonsillitisIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Decision-making for intensive care unit admissions - Understanding and improving the decision-making process surrounding admission to the intensive care unitIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing a Magnetic Resonance Imaging Biomarker for Parkinson's - Developing a Magnetic Resonance Imaging Biomarker for Parkinson'sIn Set-Up Pending NHS PermissionObservationalNo
 Developing a system for robust and rapid simultaneous EEG-fMRI - The fast without the spurious: developing a system for robust and rapid simultaneous EEG-fMRI measurementsIn Set-Up Pending NHS PermissionObservational 
 Development of a lifestyle service pathway in NAFLD - Development of the first evidence based lifestyle service pathway for people with non-alcoholic fatty liver disease (NAFLD) Phase 1: Exploring the current service pathwayIn Set-Up Pending NHS PermissionObservationalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Dex - CSDH Trial - A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematomaIn Set-Up Pending NHS PermissionInterventionalNo
 Dex – CSDH Trial - A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematomaIn Set-Up Pending NHS PermissionInterventional 
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Educational needs for spinal cord stimulation surgery - An exploration of the experiences and educational needs of patients with Failed Back Surgery Syndrome receiving spinal cord stimulation.In Set-Up Pending NHS PermissionObservationalNo
 Effect of a TNF alpha inhibitor on microglial activation in MCI - A double-blind, placebo-controlled study of the effect of a TNF alpha antibody, certolizumab pegol (Cimzia), on microglial activation in amyloid PET positive patients with Mild Cognitive Impairment due to AD-Intermediate likelihoodIn Set-Up Pending NHS PermissionInterventionalNo
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 Experiences of voluntary services staff involved in PRASE - Experiences of voluntary services staff involved in the implementation of the Patient Reporting and Action for a Safe Environment (PRASE) interventionIn Set-Up Pending NHS Permission  
 Exploring Context Change Study - Context change and effects on nebuliser adherence among people with cystic fibrosisIn Set-Up Pending NHS PermissionObservationalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility of a guided workbook intervention for cancer patients - A feasibility study of "WorkPlan" - a guided workbook intervention to support work-related goals among cancer survivorsIn Set-Up Pending NHS Permission No
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GABA­-B function in alcohol dependence - GABA­-B receptor function in alcohol dependence: a study of the effects of 2 doses of baclofen and placebo on objective and subjective measurements of brain functionIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HRQoL in Adolescents and Young Adults with Cancer - An investigation into the use of the EORTC Core instrument and the possible need of a module for the assessment of Health Related Quality of Life (HRQoL) in Adolescents and Young Adults (AYA) with cancerIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IgNiTE: Immunoglobulin in the treatment of encephalitis - A phase III multicentre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the management of children with encephalitis (The IgNiTE study)In Set-Up Pending NHS PermissionInterventional 
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 INTER-STAARS - Attention Control Training for Infants at risk of ADHD: a randomized controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 LAIV and EHPC - The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage StudyIn Set-Up Pending NHS PermissionObservationalNo
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MAGENTA: Graded Exercise Therapy Vs Activity Management - The feasibility and acceptability of conducting a trial investigating the effectiveness and cost effectiveness of Graded Exercise Therapy compared to Activity Management for paediatric CFS/ME: A feasibility randomised controlled trialIn Set-Up Pending NHS PermissionObservational 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Multimodality imaging of the aorta - Investigation into aortic structure and function using magnetic resonance imaging (MRI), computed tomography (CT) and position emission tomography (PET)In Set-Up Pending NHS Permission  
 Non-contact, hand-held device for measurement of respiratory rate - Development of the “BreathEasy”: a non-contact, hand-held device for measurement of respiratory rate (CPRM)In Set-Up Pending NHS PermissionInterventional 
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke SurvivorsIn Set-Up Pending NHS Permission  
 Ob-AKI feasibility study - The impact of obesity on recovery from acute kidney injury (AKI): the Ob-AKI feasibility studyIn Set-Up Pending NHS Permission  
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patients' views of discussing weight management with knee OA V1.15.1.15 - To understand patients’ views and experiences of discussing weight management with a health professional when they have a clinical diagnosis of knee osteoarthritis and a BMI of over 25.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 PERFECTED WP2: Implementing optimised hospital care - PERFECTED WP2: Implementing the optimisation of hospital care delivery to older adults by NHS staff via action research methodologyIn Set-Up Pending NHS Permission  
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Phenotype and function of IgE+ B cells in human bone marrow - Investigating phenotype and function of human bone marrow IgE+ B cells in allergic diseasesIn Set-Up Pending NHS PermissionObservationalNo
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Proactive Telephone Coaching & Tailored Support (PROTECTS) - A pragmatic, two-arm, patient-level, randomised trial of the effectiveness of Proactive Telephone Coaching and Tailored Support for older people with multimorbidity within the CLASSIC cohort (CLASSIC PROTECTS)In Set-Up Pending NHS Permission  
 Protein defects in retinal degenerations (version 0.9) - Investigation of protein defects in inherited retinal degenerationsIn Set-Up Pending NHS PermissionObservationalNo
 Provision Of Psychological support to People in Intensive care (v1.0) - Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI) cluster-randomised controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 Psychological impact of macular degeneration management (POPPIES) - An exploration of Patient and carer Opinions and Psychological Impact of different management strategies in the treatment of wet agerelated macular degeneration (POPPIES)In Set-Up Pending NHS PermissionObservationalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 RAIDER - A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladderIn Set-Up Pending NHS PermissionInterventional 
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Rheumatoid Arthritis Annual Review Clinic Evaluation - Understanding the role of an annual review clinic for patients with rheumatoid arthritis (RA).In Set-Up Pending NHS PermissionObservationalNo
 Safety and efficacy of the Alpha AMS subretinal implant - Safety and efficacy of the Alpha AMS subretinal implant for partial restoration of vision in visually impaired participants with degenerative retinal disease.In Set-Up Pending NHS Permissionnot specifiedNo
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 Sensitivity and specificity of corneal microscopy in polyneuropathy - Sensitivity and specificity of corneal confocal microscopy in painless and painful polyneuropathy (SeCoM) Part of the Europain CollaborationIn Set-Up Pending NHS PermissionObservationalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Simvastatin in sight threatening Uveitis trial (SU) - Can simvastatin significantly reduce the amount of immunosuppressive medication required by patients with sight threatening uveitis? A phase IIb, single site, randomized, placebo controlled, double blinded trial.In Set-Up Pending NHS PermissionInterventionalNo
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SPECIAL: Standard or PalliativE Care In Advanced Lung cancer - SPECIAL: Standard or PalliativE Care In Advanced Lung cancer Does early referral of patients with metastatic non-small cell lung cancer to UK specialist palliative care services make a difference in their quality of life or survival?In Set-Up Pending NHS PermissionObservational 
 SPRAINED Study Version 1.0 - Synthesising a clinical Prognostic Rule for Ankle Injuries in the Emergency Department (SPRAINED)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 STACEY - Stakeholders’ views and experiences of perinatal mental health care: a qualitative studyIn Set-Up Pending NHS PermissionObservationalNo
 Stress in Inflammatory Bowel disease - Identifying factors associated with stress in Inflammatory Bowel DiseaseIn Set-Up Pending NHS PermissionObservationalNo
 STRIVE HF - A multicentre randomised control trial comparing standard cardiac resynchronisation pacing with triventricular pacingIn Set-Up Pending NHS PermissionInterventional 
 Structural brain abnormalities and hypoxia in sickle cell anaemia - Structural brain abnormalities and hypoxia in sickle cell anaemiaIn Set-Up Pending NHS PermissionInterventional 
 SUMS - A multi-centre randomised controlled trial to assess the effectiveness and cost effectiveness of a home-based Self-management standing frame programme plus usual care versus usual care in people with progressive multiple sclerosis (MS) who have severely impaired balance and mobilityIn Set-Up Pending NHS PermissionInterventionalNo
 Supporting Excellence in End of Life Care (SEED): Workstream 2.4 - Supporting Excellence in End of Life Care (SEED): Workstream 2.4In Set-Up Pending NHS PermissionObservational 
 Supporting physiotherapy adherence in children with cystic fibrosis - Development of an intervention to increase physiotherapy adherence among young children with cystic fibrosis: a Medical Research Council complex intervention framework development and feasibility study   
 Survey of selfmanagement - Men’s experiences of living with and managing rheumatoid arthritis and preferences for selfmanagement services: A survey studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 TABI. - TABI: Thrombin Generation Assay to predict the efficacy of Bypassing agents in Haemophilia Patients with Inhibitors.In Set-Up Pending NHS PermissionObservationalNo
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The INFECIR2 Albumin Prevention Study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.In Set-Up Pending NHS PermissionObservationalNo
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 TNBC in D&G - Triple negative breast cancers and markers of HPV involvement:study in NHS Dumfries and GallowayIn Set-Up Pending NHS PermissionObservationalNo
 Understanding Long Standing Emotional Difficulties in Primary Care - The development of a feasible and acceptable psychological intervention for people with personality disorder traits in primary care improving access to psychological therapies (IAPT) servicesIn Set-Up Pending NHS PermissionObservationalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 WB-DW-MRI at 3T in relapsed multiple myeloma:early response assessment - Pilot study to evaluate diffusion-weighted MRI (DWMRI) Whole Body MRI in relapsed Multiple Myeloma at 3T: test-retest, early response assessment and exploratory imaging of renal function.In Set-Up Pending NHS Permission  
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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