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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A New Rehabilitation Treatment following Stroke - A randomised controlled study of early vs. late, and unisensory vs. multisensory rehabilitation for stroke patients with perceptual and cognitive impairments.In Set-Up Pending NHS Permission  
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Amyloid PET imaging in the timely diagnosis of Alzheimer's disease - Role of amyloid PET imaging in the timely diagnosis of Alzheimer’s disease in patients with underlying depression or vitamin B12/Folate deficiency: Feasibility study.In Set-Up Pending NHS PermissionInterventional 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Calibre - CALiBRe: Assessment of the Mechanism of Action of idelalisi (CAL101) in B-cell Receptor Pathway Inhibition in CLLIn Set-Up Pending NHS Permission  
 Carbetocin RTS A65870 - A Phase III, randomized, double blind, active, controlled, multinational, multicentre, noninferiority trial using Carbetocin room temperature stable (RTS) for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginallyIn Set-Up Pending NHS PermissionInterventionalNo
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Cellular immunity to herpesvirus infection: Studies with EBV & CMV -v1 - Cellular immunity to herpesvirus infection: Studies with Epstein-Barr virus and human cytomegalovirusIn Set-Up Pending NHS PermissionObservationalNo
 Characterising Phenotypes of Mtb Infection (ISIT-TB) - A Novel Whole Blood Transcriptomic Signature to Characterise Phenotypes of Mycobacterium Tuberculosis Infection (ISIT-TB)In Set-Up Pending NHS PermissionObservationalNo
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during Pregnancy   
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Developing a system for robust and rapid simultaneous EEG-fMRI - The fast without the spurious: developing a system for robust and rapid simultaneous EEG-fMRI measurementsIn Set-Up Pending NHS PermissionObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Dex – CSDH Trial - A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematomaIn Set-Up Pending NHS PermissionInterventional 
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early motion and directed exercise (EMADE) in ankle fracture fixation - Early motion and directed exercise (EMADE) post ankle fracture fixation. A pragmatic randomised controlled trial.In Set-Up Pending NHS PermissionInterventionalNo
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effect of a TNF alpha inhibitor on microglial activation in MCI - A double-blind, placebo-controlled study of the effect of a TNF alpha antibody, certolizumab pegol (Cimzia), on microglial activation in amyloid PET positive patients with Mild Cognitive Impairment due to AD-Intermediate likelihoodIn Set-Up Pending NHS PermissionInterventional 
 Efficacy of a media education programme in post gestational diabetes - A multimedia approach to diabetes structured education: The effects of "Keeping Healthy After Gestational Diabetes" on patient knowledge, self­efficacy and acceptability of a multimedia based education program.   
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 eSupportive Care - The development of an eSupportive care system to support children and young people with complex health care needs and their families to stay at homeIn Set-Up Pending NHS PermissionObservationalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 Grown in Wales - The Grown in Wales Study: Developing a placentomic tool for characterising atypical pregnancies and predicting outcomesIn Set-Up Pending NHS PermissionObservationalNo
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Imaging biomarkers in lung cancer - MRI measurement of hypoxia in NSCLC: validation and efficacy as response and toxicity biomarkersIn Set-Up Pending NHS PermissionObservational 
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Immune cells in Inflammatory Bowel Disease - Immune cells in inflammatory bowel diseaseIn Set-Up Pending NHS PermissionObservationalNo
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Inhaled Nanoparticles, Vascular Function and Translocation - Pulmonary inflammation, the systemic translocation of inhaled nanoparticles and vascular endothelial function (PRISTINE)In Set-Up Pending NHS Permission  
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 MARQUE: Dementia and agitation in domestic environments - Managing Agitation and Raising QUality of Life:   Stream 4: Qualitative study of people with dementia and agitation and their family  carers living in domestic environmentsIn Set-Up Pending NHS PermissionObservationalNo
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 NACAH - The mechanism of action of N-ACetylcysteine for reducing the risk of Infection in Alcoholic HepatitisIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
 Non-contact, hand-held device for measurement of respiratory rate - Development of the “BreathEasy”: a non-contact, hand-held device for measurement of respiratory rate (CPRM)In Set-Up Pending NHS PermissionInterventional 
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke SurvivorsIn Set-Up Pending NHS Permission  
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Pleural Effusions in Critical Care - Pleural Effusions in Critical Care (PECC) is an observational trial into the evolution of pleural fluid development in critical care.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 QUEST Follow-Up Study - Follow-Up to the QUEST cohort at 10-14 yearsIn Set-Up Pending NHS PermissionObservational 
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 RAIDER - A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladderIn Set-Up Pending NHS PermissionInterventional 
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 REACT RCT - Real Time Continuous Glucose Monitoring in Neonatal Intensive CareIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 RIO - Rucaparib Window of Opportunity Study - Window study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (RIOIn Set-Up Pending NHS PermissionInterventional 
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesIn Set-Up Pending NHS PermissionInterventional 
 Sclero XIII - Sclero XIII: A phase II ,double-blind, randomized, placebo controlled study to investigate pharmacokinetics (PK), safety and efficacy of intravenous factor XIII treatment in patients with systemic sclerosisIn Set-Up Pending NHS PermissionInterventionalNo
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SPECIAL: Standard or PalliativE Care In Advanced Lung cancer - SPECIAL: Standard or PalliativE Care In Advanced Lung cancer Does early referral of patients with metastatic non-small cell lung cancer to UK specialist palliative care services make a difference in their quality of life or survival?In Set-Up Pending NHS PermissionObservational 
 Stakeholders’ views and experiences of perinatal mental health care - Stakeholders’ views and experiences of perinatal mental health care: a qualitative studyIn Set-Up Pending NHS PermissionObservational 
 Supporting Excellence in End of Life Care (SEED): Workstream 2.4 - Supporting Excellence in End of Life Care (SEED): Workstream 2.4In Set-Up Pending NHS PermissionObservational 
 Supporting physiotherapy adherence in children with cystic fibrosis - Development of an intervention to increase physiotherapy adherence among young children with cystic fibrosis: a Medical Research Council complex intervention framework development and feasibility study   
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The DISCLOSE study - The DISCLOSE study: Development and pIloting Core discLosure for infOrmed conSent for surgEryIn Set-Up Pending NHS PermissionObservationalNo
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The perceptual effects of crowding in amblyopic and developing vision - The perceptual effects of crowding in amblyopic and developing visionIn Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The role of phosphodiesterase 10A in early de novo sporadic PD - The role of phosphodiesterase 10A in early de novo sporadic PD: An in vivo positron emission tomography studyIn Set-Up Pending NHS PermissionInterventional and Observational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 THERAPIST Version 1.0 - Investigating relationships between IL-17, Th17 pathway activation and therapeutic response to TNF inhibition in RA patients.In Set-Up Pending NHS PermissionObservationalNo
 TNBC in D&G - Triple negative breast cancers and markers of HPV involvement:study in NHS Dumfries and GallowayIn Set-Up Pending NHS PermissionObservationalNo
 TORCMEK - A Phase Ib/IIa study of AZD2014 in combination with Selumetinib in patients with advanced cancersIn Set-Up Pending NHS PermissionInterventional 
 Understanding Mental Health in the Emergency Department - Understanding how to improve the quality of Emergency Department care, as measured by process measures (length of time in ED), patient experience and safety (patients absconding from ED).In Set-Up Pending NHS PermissionObservationalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 WB-DW-MRI at 3T in relapsed multiple myeloma:early response assessment - Pilot study to evaluate diffusion-weighted MRI (DWMRI) Whole Body MRI in relapsed Multiple Myeloma at 3T: test-retest, early response assessment and exploratory imaging of renal function.In Set-Up Pending NHS Permission  
 WEBPaMS - WEB-Based Physiotherapy for People with Multiple SclerosisIn Set-Up Pending NHS PermissionInterventionalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 YoDA BRCA: Genetic Testing Decision Aid for young women - YoDA BRCA: Development and pilot testing of a web­based Genetic Testing Decision Aid for young women newly  diagnosed with early stage breast cancerIn Set-Up Pending NHS PermissionObservational 




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