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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A pilot RCT of a brief mindfulness therapy in secondary care - A pilot randomised feasibility trial of a brief mindfulness-based intervention in a mental health secondary care settingIn Set-Up NHS Permission ReceivedInterventional 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ABDose - Modelling antimicrobial pharmacokinetics in critically ill patientsIn Set-Up Pending NHS PermissionObservationalNo
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 ARENA study - Effectiveness and cost-effectiveness of outpatient physiotherapy after knee replacement: A randomised controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 ATAFUTI - Alternative Treatments of Adult female Urinary Tract infection: a double blind randomised controlled trialIn Set-Up Pending NHS Permission  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 CARDAMON - Carfilzomib/Cyclophosphamide/Dexamethasone with maintenance carfilzomib in untreated transplant-eligible patients with symptomatic MM to evaluate the benefit of upfront ASCTIn Set-Up Pending NHS Permission  
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 COCAPP-A: Collaborative Care Planning Project-Acute - Cross-national comparative study of recovery-focused mental health care planning in acute inpatient mental health settings (COCAPP-A)In Set-Up Pending NHS Permission  
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 Confidence After Stroke Measure - Confidence After Stroke MeasureIn Set-Up Pending NHS PermissionObservational 
 C-STICH - The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) Trial: A Randomised Controlled Trial of monofilament versus braided sutures for insufficient cervix.In Set-Up Pending NHS Permission  
 Decision-­making in breast cancer prevention: The ENGAGE study - Exploring decision-making in breast cancer prevention: The ENGAGE studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Determining important mechanisms that contribute to IBD - Determining important mechanisms that contribute to inflammatory bowel disease.In Set-Up Pending NHS PermissionObservationalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Development of the Addiction Therapist Rating Scale (ATRS) - The development of the Addiction Therapist Rating Scale (ATRS): a rating scale for evaluating the delivery of evidence based treatments used in routine practice for alcohol and illicit drug use problems.In Set-Up Pending NHS PermissionObservational 
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 DISCHARGE Pilot Study - Quality of Life and Microcosting in Patients with Stable Angina / Chest Pain: Pilot-study to the DISCHARGE trialIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effectiveness of existing diabetes self management programs - Prepost evaluation study on the effectiveness of existing diabetes self management (DSM) programs.OpenObservationalYes, within lead country only
 ELUCIDATE- Sub Study - “Patients’ experience in the ELUCIDATE trial”In Set-Up Pending NHS PermissionObservationalNo
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 ERIC-PPCI - Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI): A multicentre randomised controlled clinical studyIn Set-Up Pending NHS PermissionInterventional 
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 FURVA, Version 1.0 - A randomised, double blind, placebo controlled, phase II study of fulvestrant with or without the addition of vandetanib as treatment for patients with metastatic breast cancer resistant to aromatase inhibitor therapy.In Set-Up Pending NHS PermissionInterventionalYes, within and outside lead country
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genes & Health (version 1) - Genes & Health: a population based DNA sequencing, medical records, and recall BioResource study of British-Bangladeshi and British-Pakistani communities.In Set-Up Pending NHS PermissionObservationalNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GP Management of Prostate Cancer - General Practitioner views and understanding of prostate cancer screening and management with active surveillanceIn Set-Up Pending NHS PermissionObservational 
 GP Provision of Work-Related Advice to Cancer Patients in Scotland - Exploring the Role of General Practitioners in the Provision of Work-Related Advice Information and Support to People Living With and Beyond Cancer in Scotland   
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HIPPO - A randomized phase II trial of Hippocampal Sparing versus Conventional Whole Brain Radiotherapy after surgical section or radiosurgery in favourable prognosis patients with 1­4 brain metastasesIn Set-Up Pending NHS PermissionInterventional 
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 iFIND- 2. Further Imaging - Intelligent Fetal Imaging and Diagnosis- 2. Further Ultrasound and MR ImagingIn Set-Up Pending NHS PermissionObservationalNo
 iFIND-1. US Data - Intelligent Fetal Imaging and Diagnosis-1. Ultrasound Scan Data CollectionIn Set-Up Pending NHS PermissionObservationalNo
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Improving Outcomes in Vascular Access: The IMPROVA study. Version 1.1 - Improving Outcomes in Vascular Access: The IMPROVA study   
 Inhaled Nanoparticles, Vascular Function and Translocation - Pulmonary inflammation, the systemic translocation of inhaled nanoparticles and vascular endothelial function (PRISTINE)In Set-Up Pending NHS Permission  
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intermittent versus Continuous Feeding on the Intensive Care Unit v3 - A Phase 2 Pilot Physiological Randomised Clinical Trial to Investigate the Effect of Intermittent versus Continuous Enteral Nutrition on Muscle Wasting in Critical IllnessIn Set-Up Pending NHS PermissionInterventionalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 iTIMM - Imageguided Theranostics in Multiple MyelomaIn Set-Up Pending NHS Permission  
 Leucine and ACEi to treat sarcopenia - Perindopril and Leucine to improve muscle function in older people   
 LungTech Stereotactic Body Radiotherapy Trial - LungTech Stereotactic Body Radiotherapy (SBRT) of Inoperable Centrally Located Non-Small Cell Lung Cancer (NSCLC): A Phase II StudyIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MAGENTA ­ v1.2 - MAGENTA: Metabonomic-genomic signature correlates of clinical resistance in metastatic cancer treated with anti-EGFR therapyIn Set-Up Pending NHS PermissionObservational 
 Management of shoulder pain by UK GPs - Management of shoulder pain by UK General Practitioners (GPs): a national surveyIn Set-Up Pending NHS PermissionObservational 
 MaPLe: Molecular profiling for lymphoma - Molecular profiling for lymphomaIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Neurophysiology of fatigue in people with multiple sclerosis - Repeatability and validity of neurophysiological measure of fatigue in  multiple sclerosis patientsIn Set-Up Pending NHS Permission  
 Optimising insoles for pressure offloading - Optimisation of custom insoles for pressure relief in patients with diabetes via finite element modellingIn Set-Up Pending NHS PermissionInterventionalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patient Centred Assessment Method (PCAM) - Patient Centred Assessment Method (PCAM): improving nurse led biopsychosocial assessment of patients with long term conditions and co-morbid mental health needsIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 PERFECTED: Caring for patients with hipfracture - PERFECTED WP1 P4: A qualitative exploration of lay and professional stakeholder views of care delivery in hospitals for patients with hip-fracture & memory difficultiesIn Set-Up Pending NHS PermissionObservational 
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PIANO Study ­ PLX3397 c­KIT in advanced acral and mucosal melanoma - A Phase II Trial of PLX3397 in the Treatment of KIT Mutated Advanced Acral and Mucosal Melanoma (PIANO)In Set-Up Pending NHS PermissionInterventionalNo
 PICSO in NSTEMI Randomised Controlled Trial - PICSO in NSTEMI registry. Pressure controlled intermittent coronary sinus occlusion in NonST elevation Myocardial Infarction. An observational registryIn Set-Up Pending NHS PermissionInterventional 
 POSEIDON - Phase I/prospective randomised phase II trial Of the Safety and Efficacy of tamoxifen in combination with the Isoform selective Pi3K inhibitor GDC-0032 compared with tamoxifen alONe in hormone receptor positive, HER2 negative, metastatic breast cancer patients with prior exposure to endocrine treatmentIn Set-Up Pending NHS PermissionInterventional 
 PRECONCEPTION CARE FOR WOMEN WITH DIABETES - Preconception care for women with type 1 or type 2 diabetes: What are the facilitators and barriers to uptake?In Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up Pending NHS PermissionObservational 
 Predicting drug and radiation sensitivity in thoracic cancers - Molecular markers of early detection, therapeutic stratification and response in thoracic cancersIn Set-Up Pending NHS PermissionObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 Pregnancy Adaptations In Renal disease Study (PAIRS) - Pregnancy Adaptations in Renal Disease Study: a prospective observational study of predictive and diagnostic biomarkers in women with chronic kidney disease for the development of pre-eclampsia, acute kidney injury and physiological renal change in pregnancyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 PRISM: PRogesterone In Spontaneous Miscarriage - Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A randomised placebo-controlled trial (PRISM Trial: PRogesterone In Spontaneous Miscarriage Trial)In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 Psychoeducational Intervention for Parents with Personality Disorders - Feasibility study of a psychoeducational parenting intervention for families with parental personality disorders and child mental health needsIn Set-Up Pending NHS Permission  
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Risk Factors Leading to Hospital Infection - An Epidemiological Study of Host and Microbial Risk Factors Leading to Acquisition of Hospital InfectionIn Set-Up Pending NHS PermissionObservationalNo
 Rotigotine and Memory in Parkinson's. - The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive ImpairmentIn Set-Up Pending NHS PermissionInterventional 
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 SNAPSHOT - SNAPSHOT: Using a novel data capture tool to explore sedentary behaviour, nutrition and associated behaviours in younger adults with type 2 diabetes   
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Studies into SAH v1.0 - Studying subarachnoid haemorrage using multiple techniquesIn Set-Up Pending NHS PermissionObservationalNo
 Supplemental oxygen in OSA following CPAP withdrawal - The effects of supplemental oxygen on obstructive sleep apnoea (OSA) and its vascular consequences during continuous positive airway pressure therapy withdrawalIn Set-Up Pending NHS PermissionInterventionalNo
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 TB038 Heterologous effects of BCG - Evaluation of the heterologous effects of Bacille Calmette-Guérin (BCG) vaccination in healthy UK adults.In Set-Up Pending NHS PermissionObservationalNo
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The genetic aetiology of chemotherapy induced cardiotoxcity - The genetic aetiology of acute early onset chemotherapy induced cardiotoxicity in childrenIn Set-Up Pending NHS PermissionObservational 
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The VIOLET study - VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilotIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 ToSCA - Trial of Sertraline versus CBT for generalised Anxiety - A Phase IV randomised controlled trial of the selective serotonin reuptake inhibitor Sertraline versus Cognitive Behavioural Therapy for anxiety symptoms in people with Generalised Anxiety Disorder (GAD) who have failed to respond to low intensity psychological interventions as defined by the NICE GAD guidelinesIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 TREATT: Trial to EvaluAte Tranexamic acid therapy in Thrombocytopenia - A double blind, randomised controlled trial evaluating the safety and efficacy of Tranexamic acid in patients with haematological malignancies with severe thrombocytopeniaIn Set-Up Pending NHS PermissionInterventionalNo
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 VAN. - Understanding variation in rates of ambulance service ‘non-conveyance of patients to an emergency department’In Set-Up Pending NHS PermissionObservationalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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