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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 "Burst" SCS Study - Analgesic efficacy of "burst" and tonic (500Hz) Spinal Cord Stimulation patterns: A randomised place-bocontrolled studyIn Set-Up Pending NHS PermissionInterventionalNo
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A feasibility study for cardiac rehabilitation in stroke patients - A feasibility study to identify attitudes, determine outcome measures and develop an intervention to inform a definitive trial that will determine the effectiveness of adapted cardiac rehabilitation for subacute stroke patientsIn Set-Up Pending NHS PermissionObservational 
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 A UK online 24h dietary recall tool: practical application V1 - A UK online 24h dietary recall tool for large scale population studies: practical application   
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Ablation Versus Anti-arrhythmic Therapy in reducing hospital episodes - Ablation Versus Anti-arrhythmic Therapy for Reducing All Hospital Episodes from Recurrent Atrial FibrillationIn Set-Up Pending NHS PermissionInterventional 
 Acelarin(NUC1031) plus Carboplatin for recurrent ovarian cancer - Phase IB open label study to assess the safety, pharmacokinetics and clinical activity of Acelarin (NUC-1031) given on days 1 & 8 with carboplatin on day 1, every three weeks for 6 cycles in participants diagnosed with recurrent ovarian cancer.In Set-Up Pending NHS Permission  
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
31208535AFFECT Trial - AFFECT TrialIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within and outside lead country
 Androgens and adipose tissue - Effects of androgens on human adipose tissue   
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Automated EMGpara for COPD - Myotrace: Clinical evaluation of a novel system for the acquisition and automated analysis of parasternal EMG signals in patients with COPDIn Set-Up Pending NHS PermissionObservationalNo
 Beyond TME - The role of MRI in improving surgical technique and outcomes in exenterative pelvic surgery for locally extensive primary or recurrent rectal cancerIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within and outside lead country
 BISCA Version 2.0 24/06/14 - Adapting a behavioural support intervention for smokeless tobacco cessation in South Asians (BISCA)In Set-Up Pending NHS Permission  
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Body composition & chemo response & toxicity in early breast cancer - CANDO-2: A feasibility and pilot cohort study to investigate body composition and chemotherapy response and toxicity in early breast cancerIn Set-Up Pending NHS Permission  
 CAH (feasibility study) - A cluster randomised trial of clinically-assisted hydration for cancer patients in the last days of life (feasibility study)In Set-Up Pending NHS PermissionInterventional 
 Can aldosterone predict sinus after treatment of AF? - Does aldosterone predict maintenance of normal sinus rhythm after treatment of atrial fibrillation?   
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 CHM for RUTIs - A randomised, double-blind, placebo controlled, feasibility study exploring the role of Chinese herbal medicine in the treatment of women with recurrent urinary tract infectionsIn Set-Up Pending NHS Permission  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Co-administration of RTS,S and viral vectors expressing ME-TRAP - A Phase I/IIa Sporozoite Challenge Study to Assess the Safety and Protective Efficacy of Concomitant Administration of the Combination Malaria Vaccine Candidate Regimen of RTS,S/AS01¬B + ChAd63 and MVA encoding ME-TRAP and also RTS,S/AS01B aloneIn Set-Up Pending NHS PermissionInterventionalNo
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 Comprehensive Geriatric Assessment - How best to deliver comprehensive geriatric assessment (CGA) in a cost-effective way: Modern acute care for older peopleIn Set-Up Pending NHS Permission  
 Computer Model Indices to Individualise Heart Failure Treatment - Computer model derived indices for optimal patient-specific treatment selection and planning in heart failureIn Set-Up Pending NHS PermissionObservational 
 Defining disease progression in ALS (v1.0) - Defining disease progression in Amyotrophic Lateral Sclerosis (ALS): A novel analytic approach using existing clinical and imaging datasetsIn Set-Up Pending NHS PermissionObservational 
 Dementia in the workplace - Dementia in the workplace: a feasbility study exploring the employment related experiences of people with dementia or mild cognitive impairment and their employers and coworkers to identify the potential for continued employment postdiagnosisOpenObservationalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityIn Set-Up Pending NHS Permission  
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 DISPROPRICUS - Disproportionate care in the ICU’s : a multicenter international longitudinal studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 DRN 900 - study diabetesIn Set-Up Pending NHS PermissionObservational 
 DSD Life - A Multi-Centre Clinical European Study on the Outcome of Surgical, Hormonal and Psychological Intervention in Disorders of Sexual Development.   
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effects of Cholecalciferol Supplementation on EPO Requirements - Evaluation of the effectiveness of Cholecalciferol Supplementation in Haemodialysis Patients: The Impact on Erythropoietin (EPO) Requirements and Quality of LifeIn Set-Up Pending NHS Permission No
 EFSA-DON in urine trial - Occurrence data collection of deoxynivalenol (DON) and its metabolites in urine of human group populationsOpenObservationalNo
 ElaTION - The efficacy and cost effectiveness of Real Time Ultrasound Elastogrophy in the investigation of thyroid nodules and the diagnosis of thyroid cancer.In Set-Up Pending NHS Permission  
 EORTC 90091-10093 - Trastuzumab in HER2-negative Early breast cancer as Adjuvant Treatment for Circulating Tumour Cells (CTC) ("Treat CTC" trial)In Set-Up Pending NHS Permission  
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 EORTC Quality of Life Module for patients with vulva cancer - Phase 3-4 development of a questionnaire to address treatment morbidity and assess the quality of life following treatment for vulva cancerIn Set-Up Pending NHS PermissionObservational 
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Evaluation of a new self-administered visual field screening tool - Development and evaluation of a self-administered/assisted visual field screening tool for glaucomaIn Set-Up Pending NHS PermissionObservationalNo
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitation   
 Follow up protocol to the Opsona OPN305-102 study - A Three-Part, Multi-centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Sequential Adaptive, Phase II Study to Evaluate the Safety, Tolerability and Efficacy of OPN-305, a Humanised Monoclonal Antibody that Blocks Toll-Like Receptor 2, in Renal Transplant Patients at High Risk of Delayed Graft FunctionIn Set-Up Pending NHS Permission  
 Future Care Study - The Future Care Study: Decision making concerning eating and drinking for people with progressive neurological disease with and without decision making capacity; patient, public, professional and family perspectivesIn Set-Up Pending NHS PermissionObservational 
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENPET: Targeted FCH-PET imaging based on genetic profile - Detection of metastatic disease in BRCA mutation carrier prostate cancer patients with optimised imaging protocolsIn Set-Up Pending NHS PermissionInterventional 
 GENPROS. - GENPROS - Analysing outcomes after prostate cancer diagnosis and treatment in carriers of rare germline mutations in cancer predisposition genesIn Set-Up Pending NHS PermissionObservational 
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 hepatitis E virus (HEV) infection and neurological disease - An observational cohort study to identify the association of hepatitis E virus (HEV) infection with neurological disease.In Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 Imaging in Transforming Gliomas - Translocator Protein Expression in Transforming GliomasIn Set-Up Pending NHS Permission  
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 IMMUNOTACE - A randomised phase II clinical trial of conditioning cyclophosphamide and chemoembolisation with or without vaccination with dendritic Cells pulsed with HepG2 lysate in vivo in patients with Hepatocellular CarcinomaIn Set-Up Pending NHS PermissionInterventional 
 Immunotherapy for prostate cancer - Development of novel immunotherapies for prostate cancerIn Set-Up Pending NHS Permission  
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Informed Consent for PCI: Questionnaire Study - Mixed methods study to optimise informed consent for Percutaneous Coronary Intervention (PCI) in clinical practice: Questionnaire StudyIn Set-Up Pending NHS PermissionObservational 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 JAVA-P - A phase II study of Cabazitaxel chemotherapy in relapsed locally advanced and/or metastatic carcinoma of the penisIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Measuring Quality in Community Nursing: A mixed methods study - Measuring Quality in Community Nursing: A mixed methods studyIn Set-Up Pending NHS PermissionObservational 
 MErCuRIC1: MEK and MET Inhibition in Colorectal Cancer - A Phase I study of MEK1/2 inhibitor PD0325901 with cMET inhibitor PF02341066 in KRASMT and KRASWT(with aberrant cMET) Colorectal Cancer PatientsIn Set-Up Pending NHS Permission  
 Metformin for endometrial cancer RCT - Presurgical metformin for women with endometrial cancer: a randomised placebo controlled trialIn Set-Up Pending NHS PermissionInterventional 
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MicroRNAs as biomarkers for acne scarring - MicroRNAs as mechanism-based biomarkers of wound scarring and repair in acneIn Set-Up Pending NHS PermissionObservationalNo
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Mobilising knowledge across health and social care boundaries - Mobilising knowledge across health and social care boundaries in community settings: understanding and developing the role of knowledge brokeringIn Set-Up Pending NHS PermissionObservational 
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 Monitoring and Managing from Ward to Board - Information Systems: Monitoring and Managing From Ward to BoardIn Set-Up Pending NHS Permission  
 Msk Evaluation - Evaluation of the redesigned NHS Lanarkshire Musculoskeletal Service   
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PANDA (gynaecology) - A Single Arm Phase II trial of BMN 673 for inoperable, advanced endometrial cancer with retrospective PTEN, MSI and MRE11 analysisIn Set-Up Pending NHS PermissionInterventionalNo
 Patient Centred Assessment Method (PCAM) - Patient Centred Assessment Method (PCAM): improving nurse led biopsychosocial assessment of patients with long term conditions and co-morbid mental health needsIn Set-Up Pending NHS Permission  
 PEPPeRS - PEPPeRS - Multidisciplinary Person Centred Caring: Its conceptualisation and measurement through three instruments (PErsonalisation, ParticiPation and ResponSiveness)In Set-Up Pending NHS Permission No
 Phase 1B and 1C Clinical trial of PP1420 - A DoubleBlind, Randomised, PlaceboControlled Dose Escalation Study to Assess the Safety, Tolerability and Efficacy of Single and Multiple Doses of PP 1420 in Healthy Subjects   
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PICTURE BREAST Longitudinal - PICTURE: Patient Information Combined for local Therapy oUtcome assessment in bREast cancer - longitudinalIn Set-Up Pending NHS Permission  
 PICTURE BREAST XS (cross-sectional) - PICTURE Breast XS: Patient Information Combined for local Therapy oUtcome assessment in bREast cancer cross-sectionalIn Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 PROCAS – Lifestyle Breast Cancer Prevention Feasibility Study - Prevention of Cancer at Screening: Lifestyle Prevention (PROCAS - Lifestyle Prevention) Feasibility Study - Does personalised information about risk of cardiovascular disease and diabetes enhance uptake and adherence to a weight loss programme amongst women who receive breast cancer risk feedback in the NHS Breast Cancer Screening Programme?In Set-Up Pending NHS Permission  
 PROWESS - A feasibility study of delivering a culturally adapted group based breast cancer self-management intervention in a community setting, designed to enhance confidence to self-manage following treatment for primary breast cancer and promote peer support, among women from different ethnic and socio-economic backgroundsIn Set-Up Pending NHS Permission  
 PSP CBD MSA Longitudinal Study UK - PROgressive Supranuclear Palsy CorTicoBasal Syndrome Mulitple System Atrophy Longitudinal Study UK (PROSPECTMUK)   
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 RCT of Comprehensive Geriatric Assessment in a HAH setting v 1.0 - A Multi-Centre Randomised Controlled Trial to Compare the Effectiveness of Admission Avoidance Hospital at Home with Comprehensive Geriatric Assessment vs. Inpatient Comprehensive Geriatric Assessment on the Number of Frail Older People ‘Living at Home’In Set-Up Pending NHS Permission  
 REASURE (Radium-223: Evaluation of Activity and SUrrogate REsponse) - A phase II randomised trial of biomarkers to assess (dose) response in patients with metastatic castration resistant prostate cancer treated with radium-223In Set-Up Pending NHS Permission  
 redi: Risk-assessed Exercise & Diet Intervention - Stage 1 - redi: Risk-assessed Exercise and Diet Intervention for men with prostate cancer: Stage I - Proof of conceptIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Resilience in young adults with T1D - Resilience in young adults with T1D   
 Resources for Living (R4L) Pilot - Resources for Living (R4L) Pilot: Exploring the Potential of Progressive Cuisine for Quality of Life Improvement for Head and Cancer SurvivorsIn Set-Up Pending NHS PermissionObservational 
 Retinal photography in older HIV positive adults - Using retinal photography to estimate cerebrovascular and cardiovascular health in HIV positive adults aged over fifty, HIV negative controls aged over fifty, and younger HIV positive adultsIn Set-Up Pending NHS PermissionObservational 
 Risk assessment for PTBD +/stenting - Risk stratification scoring for percutaneous transhepatic biliary drainage (PTBD), with or without stenting.In Set-Up Pending NHS Permission  
 SHAPE - Simple Hysterectomy And Pelvic node dissection in Early cervix cancer - A randomized phase III trial comparing radical hysterectomy and pelvic node dissection versus simple hysterectomy and pelvic node dissection in patients with low-risk early-stage cervical cancerIn Set-Up Pending NHS Permission  
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SORAMIC - Evaluation of Sorafenib in combination with local microtherapy guided by GdEOBDTPA enhanced MRI in patients with inoperable hepatocellular carcinomaIn Set-Up Pending NHS PermissionInterventional 
 Standardised NBIA Patient Registry and Natural History Study - Standardised NBIA Patient Registry and Natural History StudyIn Set-Up Pending NHS PermissionObservational 
 STOP-HCV Cirrhosis Study - Prognostic biomarkers in HCV cirrhosis.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Stratification of patellofemoral pain (StrOPP) - Stratification of patellofemoral pain using clinical, biomechanical and imaging features.In Set-Up Pending NHS PermissionObservationalNo
 Testing a new stepwise strategy for the management of renal anaemia - Testing a new stepwise strategy for the management of renal anaemia in primary care: An exploratory cluster randomised trialIn Set-Up Pending NHS PermissionInterventional and Observational 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The MUNROS project: the questionnaires (Work Packages 4,5 and 6) - Health Care Reform: the iMpact on practice, oUtcomes and costs of New roles for health pROfeSsionals (MUNROS). WP 4, 5 and 6: The Surveys   
 The Plymouth EarlyBird 3 Study - Childhood predictors of long term health: The Plymouth EarlyBirds as adults (The EarlyBird 3 study)   
 The Pulses Study - Pulsed glucocorticoid replacement therapy for patients with adrenocortical insufficiency secondary to Addison’s disease and congenital adrenal hyperplasiaIn Set-Up Pending NHS Permission  
 The REACT study - The REACT study: Establishing what relationship exists between fungal colonisation and allergy and the clinical, radiological and pathological characteristics of lung disease.In Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The role of obesity and diabetes in endometrial cancer - OBITEC: Uncovering obesity and diabetes related complex metabolic dysregulation associated to endometrial cancer   
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 THYRoxine in Acute Myocardial Infarction (ThyrAMI) - THYRoxine in Acute Myocardial Infarction (ThyrAMI)   
 Trajectories of Outcome in Neurological Conditions Sub-Study 4 Longtitudinal - Trajectories of Outcome in Neurological Conditions: Quality of Life (QoL) and neurological disease Sub-Study4 LongtitudinalIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 TRIP - Testing in recreational settings prevention - interventions addressed to polydrug users - TRIP - Testing in recreational settings prevention - interventions addressed to polydrug usersClosedObservationalN/A
 Tropomyosin Receptor kinase Antagonism in Cylindromatosis (TRAC) - Topical tropomysin kinase (TRK) inhibitor as a treatment for inherited CYLD defective skin tumours (TRAC)In Set-Up Pending NHS PermissionInterventionalNo
 Understanding meningococcal carriage and disease - A multi-centre cross sectional study of meningococcal oropharyngeal carriage in healthy teenagers in the UKIn Set-Up Pending NHS Permission  
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Undiagnosed Lupus-Like Autoimmunity and unexplained stillbirth - Undiagnosed Lupus-like autoimmunity and unexplained stillbirthIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Urodynamic assessment methods before Prostate Surgery - A randomised controlled trial to determine the clinical and cost effectiveness of invasive urodynamic studies for diagnosis and management of bladder outlet obstruction in men in the National Health Service (NHS)In Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 VERDIS: Video-based communication research in a hospice - Video-based communication research and training in decision-making and empathy in supportive and palliative careOpennot specifiedNo
 viral hepatitis case-finding in primary care - A Feasibility Study of Case-Finding Strategies for the Detection of Hepatitis B and C in Primary CareIn Set-Up Pending NHS PermissionObservational 
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 Whole body PET-MRI in paediatric and adolescent Hodgkin Lymphoma - Feasibility of using whole body PET-MRI to stage and restage paediatric and adolescent lymphoma – a pilot study.In Set-Up Pending NHS Permission  




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