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Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A comparative ethnographic investigation into the culture, organisation, management techniques and e - A comparative ethnographic investigation into the culture, organisation, management techniques and environmental features of high-secure mental health units   
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A randomised, controlled trial to determine the median effective concentration of bupivacaine, levob - A randomised, controlled trial to determine the median effective concentration of bupivacaine, levobupivacaine and ropivacaine after intrathecal and extradural injection for pain relief in the first stage of labour.ClosedInterventionalN/A
 aaaTestStudy_LT - aaaTestStudy_LT test recordIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 An evaluation of a real-time survey for improving patient experiences - An evaluation of a real-time survey for improving patients’ experiences of the relational aspects of careIn Set-Up Pending NHS PermissionObservational 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Baby-OSCAR Trial - Outcome After Selective Early Treatment for Closure of Patent Ductus Arteriosus in Pre-term BabiesIn Set-Up Pending NHS PermissionInterventionalNo
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 CanACT feasibility - The addition of ACT or a Talking Control to treatment as usual for the management of dysfunction in advanced cancer: A feasibility randomised controlled trialIn Set-Up Pending NHS Permission  
 CARDAMON - Carfilzomib/Cyclophosphamide/Dexamethasone with maintenance carfilzomib in untreated transplant-eligible patients with symptomatic MM to evaluate the benefit of upfront ASCTIn Set-Up Pending NHS Permission  
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 CLEFT-Q Fieldtest - An International Study to Develop a Patient-Reported Outcome Measure for Cleft Lip and/or Palate Patients: The CLEFT-QIn Set-Up Pending NHS PermissionObservational 
 closED. - Impact of closing Emergency Departments in England   
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Collaborative case management to aid return to work - Collaborative case management to aid return to work after long term sickness absence: a pilot randomised controlled trialIn Set-Up Pending NHS PermissionObservational 
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 Confidence After Stroke Measure - Confidence After Stroke MeasureIn Set-Up Pending NHS PermissionObservational 
 Cortisol profiles in the critically ill after cardiac surgery - Cortisol profiles in the critically ill after cardiac surgeryIn Set-Up Pending NHS PermissionObservationalNo
 Decision-­making in breast cancer prevention: The ENGAGE study - Exploring decision-making in breast cancer prevention: The ENGAGE studyIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 DISCHARGE Pilot Study - Quality of Life and Microcosting in Patients with Stable Angina / Chest Pain: Pilot-study to the DISCHARGE trialIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effective Home Support Dementia Care:Patterns of Current Provision v1 - EFFECTIVE HOME SUPPORT IN DEMENTIA CARE: COMPONENTS,  IMPACTS AND COSTS OF TERTIARY  PREVENTION:Preparatory Studies(Project 1.2 Patterns of Current Provision in England)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 ELUCIDATE- Sub Study - “Patients’ experience in the ELUCIDATE trial”In Set-Up Pending NHS PermissionObservationalNo
 Enterococcus faecium hospital/farm/environment study - The relative importance of human and animal sources of vancomycin-resistant Enterococcus faeciumIn Set-Up Pending NHS PermissionObservationalNo
 ENZAMET - Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancerIn Set-Up Pending NHS PermissionInterventional 
 EORTC Clinical Trial 10994 - EORTC Clinical Trial 10994 - BIG p53 First Prospective Intergroup Translational Research Trial Assessing Predictive Value of p53 Using a Functional Assay in Patients with Locally Advanced Inflammatory or Large Operable Breast Cancer Prospectively RandomisClosedObservationalN/A
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Factors that affect clinical decision making in cancer MDT meetings - Assessment of cognitive and social-interactional factors, and implementation of intervention for improvement of decision making in cancer MDT meetings: A mixed design studyIn Set-Up Pending NHS PermissionObservational 
 Factors that influence antibiotic prescribing habits for acne - Identifying factors that influence antibiotic prescribing habits for acne with a view to changing prescribing behaviours and optimising patient care by minimising the emergence of antimicrobial resistance.In Set-Up Pending NHS PermissionObservationalNo
 Faecal s-RAGE - s-RAGE and calprotectin in samples of human faeces and bloodIn Set-Up Pending NHS PermissionObservationalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENFI IMPETus Tau PET imaging pilot study - Genetic Frontotemporal dementia Initiative (GENFI) – IMPETus Tau PET imaging pilot study   
 Genomics of diabetic retinopathy in the UK - Investigating diabetic retinopathy: A study of the clinical epidemiology, cellular and population genomics of diabetic retinopathy among primary care patients in the UK   
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Heart failure revascularization - Heart failure revascularization trial UK (HEART UK)    
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HIPPO - A randomized phase II trial of Hippocampal Sparing versus Conventional Whole Brain Radiotherapy after surgical section or radiosurgery in favourable prognosis patients with 1­4 brain metastasesIn Set-Up Pending NHS PermissionInterventional 
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identification and characterisation of novel therapeutic targets for angiogenesis-based disorders 1 - Identification and characterise novel therapeutic targetts for angiogenesis-based disorders of pregnancy - (HUVECS)ClosedObservationalN/A
 Identification of Novel Psychoactive Substances (IONA) - Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy 3 - Identify and characterise novel therapeutic targets for angiogenesis-based disorders of pregnancy - tissue biomarkersClosedObservationalN/A
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Improving post hypoglycaemic follow-up care - An assessment of the feasibility, and potential impact of a dual intervention to improve self-referral rates to diabetic care following hypoglycaemic emergencies.Closed N/A
 Inhaled Nanoparticles, Vascular Function and Translocation - Pulmonary inflammation, the systemic translocation of inhaled nanoparticles and vascular endothelial function (PRISTINE)In Set-Up Pending NHS Permission  
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 iTIMM - Imageguided Theranostics in Multiple MyelomaIn Set-Up Pending NHS Permission  
 KYN: Alcohol and breast cancer prevention - prevention Know Your Numbers (KYN): Adding Primary Prevention to the NHS Breast Screening Programme Phase IIn Set-Up Pending NHS PermissionObservational 
 Lifestyle in Later Life - An evaluation of the determinants of lifestyle and health behaviours in later life, and to investigate their relationship with health outcomesIn Set-Up Pending NHS PermissionObservational 
 LungTech Stereotactic Body Radiotherapy Trial - LungTech Stereotactic Body Radiotherapy (SBRT) of Inoperable Centrally Located Non-Small Cell Lung Cancer (NSCLC): A Phase II StudyIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MAGENTA ­ v1.2 - MAGENTA: Metabonomic-genomic signature correlates of clinical resistance in metastatic cancer treated with anti-EGFR therapyIn Set-Up Pending NHS PermissionObservational 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Measurement of chlamydia antibodies using residual GUM specimens - Investigation of measured antibody response to Chlamydia trachomatis infection in women with known clinical histories using residual serum samples collected from genitourinary medicine (GUM) clinic attendersIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Metabonomic and Microbiomic profile of Pruritus and Fatigue in PBC - Metabonomic and Microbiomic profile of Pruritus and Fatigue in Primary Biliary Cirrhosis.In Set-Up Pending NHS PermissionObservationalNo
 Methylnaltrexone for the Treatment of Opioid Induced Constipation - Use of Methylnaltrexone for the Treatment of Opioid Induced Constipation & GastroIntestinal Stasis in Intensive Care PatientsIn Set-Up Pending NHS PermissionInterventionalNo
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 MRC-BLISS - MRC Bipolar Lithium Imaging and Spectroscopy Study (BLISS)In Set-Up Pending NHS PermissionObservational 
 N-Acetylcysteine in patients with Sickle Cell Disease - N-Acetylcysteine in patients with Sickle Cell Disease. Reducing the incidence of daily life pain in patients with sickle cell diseaseIn Set-Up Pending NHS PermissionInterventionalNo
 Nail bed INJury Analysis (NINJAP) - Nail bed INJury Analysis (NINJA) Pilot Study: Should the nail plate be replaced or discarded after nail bed repair in children?In Set-Up Pending NHS PermissionInterventionalNo
 Non-contact, hand-held device for measurement of respiratory rate - Development of the “BreathEasy”: a non-contact, hand-held device for measurement of respiratory rate (CPRM)In Set-Up Pending NHS PermissionInterventional 
 OCTIMISE - Optical Coherence Tomography to guIde stent placeMent durIng percutaneouS coronary intErventionIn Set-Up Pending NHS PermissionInterventional 
 OPTIMISE - Optimising Pelvic floor muscle Training to Improve quality of life outcomes for individuals with progressive Multlple SclErosis and  incontinence, a feasibility study: OPTIMISEIn Set-Up Pending NHS PermissionObservational 
 Pain management in people with dementia in care homes: pilot - Pain management in people with dementia living in care homes: feasibility pilot and auditIn Set-Up Pending NHS PermissionObservationalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Patient Centred Assessment Method (PCAM) - Patient Centred Assessment Method (PCAM): improving nurse led biopsychosocial assessment of patients with long term conditions and co-morbid mental health needsIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 PEACE (Posthumous tissuE donAtion in CancEr) - The PEACE (Posthumous tissuE donAtion in CancEr) StudyIn Set-Up Pending NHS Permission  
 PETRA:Threatened preterm labour-risk and care management v.1 - Threatened preterm labour: a prospective cohort study of a clinical risk assessment tool and a qualitative exploration of women's experiences of risk assessment and management.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Physical Activity Questionnaire for CKD - Development and Validation of a Physical Activity Questionnaire for Subjects with Chronic Kidney DiseaseIn Set-Up NHS Permission Receivednot specifiedNo
 PIANO Study ­ PLX3397 c­KIT in advanced acral and mucosal melanoma - A Phase II Trial of PLX3397 in the Treatment of KIT Mutated Advanced Acral and Mucosal Melanoma (PIANO)In Set-Up Pending NHS PermissionInterventionalNo
 Pneumo carriage, PIN study - A study to assess the carriage of pneumococci in children aged 1-5 years, and their household contactsIn Set-Up Pending NHS PermissionObservational 
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up Pending NHS PermissionObservational 
 Predicting drug and radiation sensitivity in thoracic cancers - Molecular markers of early detection, therapeutic stratification and response in thoracic cancersIn Set-Up Pending NHS PermissionObservational 
 Predictive Biomarkers for Drugs Targeting ALK/p53 in Neuroblastoma - Pilot Study to Develop Predictive Biomarkers for Drugs Targeting the ALK and p53 Pathways for Children with NeuroblastomaIn Set-Up Pending NHS PermissionObservational 
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Responsiveness and MID of 4MGS in IPF - Responsiveness of the 4 metre gait speed (4MGS) in patients with idiopathic pulmonary fibrosis (IPF) and determination of the minimum important difference (MID)In Set-Up Pending NHS PermissionObservationalNo
 RIGHT-2 - Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT2): Assessment of safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor, and of the feasibility of a multicentre ambulance-based stroke trialIn Set-Up Pending NHS PermissionInterventional 
 Rotigotine and Memory in Parkinson's. - The Effect of Rotigotine on Memory in Idiopathic Parkinson's Disease without Cognitive ImpairmentIn Set-Up Pending NHS PermissionInterventional 
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 SIOP Ependymoma II - SIOP Ependymoma II - An International Clinical Program for the diagnosis and treatment of children, adolescents and young adults with EpendymomaIn Set-Up Pending NHS PermissionInterventional 
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Testingsss - TestingIn Set-Up NHS Permission Received  
 The development of an immunoglobulin (Ig) burden of treatment question - The development of an immunoglobulin (Ig) burden of treatment questionnaireIn Set-Up Pending NHS PermissionObservationalNo
 The genetic aetiology of chemotherapy induced cardiotoxcity - The genetic aetiology of acute early onset chemotherapy induced cardiotoxicity in childrenIn Set-Up Pending NHS PermissionObservational 
 The Grey-Zone FFR Study - A randomised controlled trial in stable intermediate coronary lesions and grey-zone FFR values with evaluation of the diagnostic utility of invasive coronary physiological indices and quantitative perfusion MRI.In Set-Up Pending NHS PermissionInterventionalNo
 The Joint Symptoms Questionnaire Study - The Joint Symptoms Questionnaire StudyIn Set-Up Pending NHS PermissionObservational 
 The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative NeoplasmsIn Set-Up Pending NHS Permission  
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The SONIC study - Investigating SecONdary Immunodeficiency in Chronic kidney disease ­ the SONIC study   
 Transeuro Study - An Open Label Study To Assess The Safety And Efficacy Of Neural All-Transplantation With Fetal Ventral Mesencephalic Tissue In Patient's With Parkinson's Disease   
 TREATT: Trial to EvaluAte Tranexamic acid therapy in Thrombocytopenia - A double blind, randomised controlled trial evaluating the safety and efficacy of Tranexamic acid in patients with haematological malignancies with severe thrombocytopeniaIn Set-Up Pending NHS PermissionInterventionalNo
 Two cluster RCTs to evaluate feedback in blood transfusion audits - Two linked cluster randomised trials to evaluate feedback interventions embedded within a national audit of blood transfusion practiceIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Virtual reality intervention for anxiety in children with ASD - Reducing anxiety in children with autism spectrum disorders through  virtual reality environmentsIn Set-Up Pending NHS PermissionInterventional 
 WEBPaMS - WEB-Based Physiotherapy for People with Multiple SclerosisIn Set-Up Pending NHS PermissionInterventionalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




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