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UKCRN Study Portfolio

Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A 34­week Follow­up to: MK­0431A in Pediatric Patients with Type 2 Diabetes Mellitus - A 34­week Follow­ up to: A Phase III, Multicenter, Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the  Safety and Efficacy MK­0431A (A Fixed Dose Combination Tablet of  Sitagliptin and Metformin) in Pediatric Patients with Type 2 Diabetes Mellitus.   
 A study of movement disorders in adults with 22q11 deletion syndrome - A study of movement disorders in adults with 22q11 deletion (Di George syndrome)In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Adult onset type 1 - diabetes ­ the PROCEED study - An Exploratory Study to Develop a Supportive Programme of Care for Adult Onset - Type 1 Diabetes­ the PROCEED study.   
 An Analysis of Long-Term Health Outcomes in Ex-Cricketers - A phase 1 cross-sectional study investigating the risk factors for and prevalence of self-reported OA and long-term outcomes within English cricket and the prevalence of significant injuryIn Set-Up Pending NHS PermissionObservational 
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Antiseptic Randomised Controlled Trial for Insertion of Catheters v1.0 - The efficacy and safety of two topical antiseptic solutions for skin disinfection prior to percutaneous central venous catheter insertion in preterm neonates: a feasibility studyIn Set-Up Pending NHS PermissionInterventionalNo
 AURORA. - AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.   
 Baronet - Biological and radiological outcomes of neoadjuvant endocrine treatment (BARONET).   
 Beliefs, Emotions, Criticism and Suicidality ­- Version 1 - An investigation into the relationship between emotions, beliefs,  coping strategies and self criticism with suicidality;  Beliefs, Emotions, Criticism and Suicidality (BECS: INSITE)   
 BIO BEHÇET’S - Optimal utilisation of biologic drugs in Behçet’s Disease: a randomised controlled trial of infliximab (IFX) verses alpha interferon (aIFN), with genotyping and metabolomic profiling, towards a stratified medicines approach to treatment.   
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Bowditch revisited: defining the optimum heart rate range in CHF - Bowditch revisited: defining the optimum heart rate range in chronic heart failureIn Set-Up Pending NHS PermissionInterventionalNo
 Bowel Dysfunction in MS - Bowel Dysfunction in multiple sclerosis: a qualitative study of people with MS and their family carersIn Set-Up Pending NHS PermissionObservational 
 Canine Olfactory Detection of Human Urological Cancer - Canine olfactory detection of human urological cancer from the odour of human urine samplesIn Set-Up Pending NHS PermissionObservationalNo
 Case­-control study of inherited women's cancer - Case­control study of individuals with increased risk of inherited women's  cancer   
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 Cerebral vasomotor regulation in atrial fibrillation (CVR-­AF) - Cerebral vasomotor regulation in atrial fibrillation (CVR-­AF)   
 CFMATTERS - Cycstic Fibrosis Microbiome determined Antimicrobial Therapy Trial in Exacerbations: Results Stratified   
 Change in narrative style as people diagnosed with schizophrenia move from inpatient to community li - Change in narrative style as people diagnosed with schizophrenia move from inpatient to community livingIn Set-Up Pending NHS Permission No
 Change in free vitamin D after high dose cholecalciferol - Change in free vitamin D after high dose cholecalciferol administered to vitamin D deficient postmenopausal women.In Set-Up Pending NHS PermissionInterventionalNo
 Changing health behaviours prior to surgery: What are your views? - Changing health behaviours prior to surgery: What are your views?In Set-Up Pending NHS Permission  
 Characterisation of myocardial inflammation in cardiomyopathies - Characterisation of myocardial inflammation in ischaemic and non-ischaemic cardiomypathiesIn Set-Up Pending NHS PermissionInterventional and ObservationalNo
 Characterization of the IgE Repertoire and Activity in Asthma, V01 - Genetic and Functional Characterization of the IgE Repertoire and Compartmental Regulation of IgE Activity in the  Pathogenesis of AsthmaIn Set-Up Pending NHS PermissionObservationalNo
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Clinical testing of the Postpartum Haemorrhage (PPH) Butterfly - The PPH Butterfly: Clinical testing for size, usability and acceptability of a new device to manage postpartum haemorrhage.   
 Cognitive and Neural Networks in Psychiatry - Cognitive and Neural Networks in PsychiatryIn Set-Up Pending NHS PermissionObservational 
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Commissioning services for adults with learning disabilities or autism - The role of quality information in commissioning social care services for adults with learning disabilities or autism ­ a survey of commissioners in EnglandIn Set-Up Pending NHS PermissionObservational 
 COMPARE-­HIV - Comparison Of Molecular & Phylogenetic Approaches to Reconstruct  an Epidemic of HIV (COMPARE­-HIV)   
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 CoRe Study v1.0 - Cortical Reorganisation in Complex Regional Pain Syndrome: A study of potential biomarkersIn Set-Up Pending NHS PermissionObservationalNo
 Creative interventions for postnatal depression - The impact of creative interventions on symptoms of postnatal  depression   
 Cyclo-oxygenase and matrix metalloproteinase modulation of angiogenesis - Cyclo-oxygenase and matrix metalloproteinase modulation of angiogenesis in normoxia and hypoxia: an in vitro comparison of artery and vein remodellingIn Set-Up NHS Permission Received  
 Daily Activities Project Version 1 - Cultural Validation of the Amsterdam IADL QuestionnaireIn Set-Up Pending NHS PermissionObservationalNo
 Delivering Pulmonary Rehabilitation with Lay Health Workers (DRILL) - Delivering Pulmonary Rehabilitation with lay health workers to improve life quality in COPD: feasibility study (DRILL study)In Set-Up NHS Permission ReceivedObservational 
 Dementia Core Outcome Set Study - Development of a core outcome set for people with dementia living at home in their neighbourhoods and communitiesOpenObservationalNo
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a PROM for Cardiac Rehabilitation - Development of a Patient-reported Outcome measure (PROM) for Cardiac RehabilitationIn Set-Up Pending NHS PermissionInterventionalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 DexEnceph 1.0 - DexEnceph: A pragmatic, randomised, controlled, observer­blind trial comparing clinical outcomes in adults who receive  dexamethasone alongside standard treatment versus standard  treatment alone for Herpes Simplex Virus encephalitis.In Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diabetic Foot Ulcer Prevention System (DFUPS) - An Innovative System for the Early Identification, Monitoring, Evaluation and Diagnosis of Diabetic Foot Ulcers   
 Dietary Nitrate and Monocyte-platelet aggregates in Atherosclerosis - Dietary Nitrate and Monocyte-platelet aggregates in Patients with AtherosclerosisClosedInterventionalN/A
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Does Gut Permeability Alter after Gastric Bypass in Type 2 Diabetes? - A pilot study to investigate whether the permeability of the intestinal mucosa is altered after Gastric Bypass surgery in patients with Type 2 diabetes.In Set-Up Pending NHS Permission  
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EASI­-SWITCH v1.0 - Early switch to oral antibiotic therapy in patients with low risk  neutropenic sepsis.   
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effectiveness of Ripple mapping for atrial tachycardia ablation - A prospective multicentre study of effectiveness of Ripple mapping for atrial tachycardia ablationIn Set-Up Pending NHS Permission  
 Engager: Evaluation of a collaborative care intervention for offenders - Evaluation of a complex intervention (Engager) for prisoners with  common mental health problems, near to and after release -­ Full Trial   
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 Evaluation of a novel cervical orthosis to support neck weakness due to neurological disease (Head u - Evaluation of a novel cervical orthosis to support neck weakness due to neurological disease (Head up)In Set-Up Pending NHS Permission No
 Experiences of decision making in pre-­dialysis patients ver.1 - Experiences of decision making in adult pre­dialysis patients and carers of kidney failure treatment options   
 Exploring the transition experiences of higher-stage medical trainees - Exploring the transition experiences of higher-stage medical trainees: A longitudinal audio-diary study across the trainee-trained/ trainee-SAS transitionIn Set-Up Pending NHS Permission  
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Feasibility of high intensity interval training in people with IPD - Can people with Parkinson's disease exercise at high intensity and, if so, what are the benefits? A feasibility studyIn Set-Up Pending NHS PermissionInterventionalNo
 Feasibility of surface EMG recordings in MND - Sequential surface EMG recordings in motor neuron disease:  fasciculations as a biomarker of motor neuron healthIn Set-Up Pending NHS PermissionObservationalNo
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 Genetic Study of Neurocognitive Substrates in OCD - Genetic Study of Neurocognitive Substrates in Obsessive­Compulsive DisorderIn Set-Up NHS Permission ReceivedInterventional and ObservationalYes, within lead country only
 GENFI Manchester - GENFIIn Set-Up Pending NHS PermissionObservational 
 Gift­-Surg – Fetal MRI - Guided Instrumentation for Fetal Therapy and Surgery: Fetal MRI to  improve prenatal diagnosis and therapy for fetal abnormality   
 GlucoCEST - Establishment of GlucoCEST MRI as a Biomarker in Cancer Translational StudyIn Set-Up Pending NHS PermissionInterventional 
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Hartmann's procedure versus intersphincteric APE: a prospective study - Hartmann's type procedure versus intersphincteric APE in patients undergoing resection of rectal cancer in whom restoration of gastrointestinal continuity is not appropriate: a multi centre, prospective observational studyIn Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 HAUS Study -­ Phase II - Feasibility and acceptability of home sampling kits to increase the  uptake of HIV testing among black Africans in the United Kingdom:  The Haus Study -­ Phase II   
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HGUS Study - A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/­ ifosfamide following surgery or in metastatic first line treatmentIn Set-Up Pending NHS Permission  
 HGUSStudy - A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/- ifosfamide following surgery or in metastatic first line treatmentIn Set-Up Pending NHS Permissionnot specified-unknown-
 Home testing of day and night closed loop with pump suspend feature - An open-label, multi-centre, randomised, single-period, parallel design study to assess the efficacy, safety, utility and psychosocial effect of 12 week day and night automated closed loop glucose control combined with pump suspend feature compared to sensor augmented insulin pump therapy in youth and adults with type 1 diabetes with sub-optimal glucose control under free living conditionsIn Set-Up Pending NHS PermissionInterventionalNo
 HOPE -­ HF - AV optimisation delivered with direct His bundle pacing, in patients  with heart failure, long PR without left bundle branch block: randomised multi­centre clinical outcome study The His Optimised Pacing Evaluated for Heart Failure Trial (HOPE­-HF)   
 Human Factor and Usability Testing of A Binocular OCT System - A Prospective Single-Site Non-Interventional Study to Evaluate Human Factors and Usability of Automated, Comprehensive Ocular Examination in Elderly and Visually Impaired Populations using a Prototype Binocular Optical Coherence Tomography SystemIn Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 ILD Controls V1.0 - Control subjects for better understanding of pathogenesis of fibrotic lung diseaseIn Set-Up NHS Permission ReceivedObservationalNo
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Impact and Evaluation of the BuRNTool - Impact and Evaluation of a Burns Risk Assessment of Neglect and Maltreatment in Children Tool. BuRNTool A multi centre studyIn Set-Up Pending NHS PermissionInterventional 
 IMPACT Imaging Pilot - IMaging pilot study of the avß6 integrin radiotracer [18F]A20FMDV2 in PAtients with solid Cancer TypesIn Set-Up Pending NHS Permission  
 Improving clinical practice for babies with hearing loss - Improving clinical practice for babies with hearing lossIn Set-Up Pending NHS PermissionInterventional 
 INCA; investigating neuronal responses by assessing cough in asthma - Investigating Neuronal responses by assessing capsaicin evoked  Cough responses in an allergen challenge model of AsthmaIn Set-Up Pending NHS PermissionInterventionalNo
 Independent Prescribing Optometrists in Acute Ophthalmic Services - Independent prescribing optometrists in Manchester Royal Eye Hospital's Acute Ophthalmic Services (UK); how do  their diagnostic, prescribing and management decisions compare with consultant ophthalmologists?In Set-Up Pending NHS PermissionObservationalNo
 Inflammatory Dendritic Cells in Arthritis - Characterization of IL17 Biomarkers and Synovial Inflammatory Dendritic Cells in Inflammatory ArthritisIn Set-Up Pending NHS PermissionObservational 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Investigating the Immune Response in Haematological Malignancies - Investigating the immune response to haematological malignancies with a view to novel therapies.In Set-Up Pending NHS PermissionObservational 
 IVAN Follow Up - Five year observational follow-up of the IVAN trial cohort: a study of function and morphologyIn Set-Up Pending NHS PermissionObservationalNo
 LAAOS III - Left Atrial Appendage Occlusion Study III (LAAOS III)In Set-Up NHS Permission ReceivedInterventionalYes, within and outside lead country
 LEAK: Lipocalin in the ED for the diagnosis of Acute Kidney injury - A multicenter prospective cohort study of the diagnostic accuracy of Neutrophil Gelatinase­Associated Lipocalin (NGAL) and Cystatin C for Acute Kidney Injury (AKI) in consecutive adult  patients admitted from the Emergency Department (ED).In Set-Up Pending NHS PermissionObservationalNo
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 Limiting chemotherapy side effects by using moxa - Using daily selfadministered indirect moxibustion to Zusanli ST36 to reduce chemotherapyinduced pancytopenia: a feasibility studyIn Set-Up Pending NHS Permission  
 Listen-In - Listen-In: the development and testing of a web-based therapy application for patients with impaired speech comprehension caused by stroke.In Set-Up Pending NHS PermissionInterventionalNo
 Longitudinal Histories-Endometriosis PCCIU - Longitudinal History Patterns for Earlier Diagnosis of EndometriosisOpen  
 LuCID: Lung Cancer Indicator Detection - LuCID: Lung Cancer Indicator DetectionIn Set-Up Pending NHS Permission  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 Macular Hole Imaging by AO­SLO (version 1.0) - Macular Hole Imaging by Adaptive Optics Scanning Laser OphthalmoscopyIn Set-Up Pending NHS PermissionObservationalNo
 Mapping and evaluating Specialist Autism Team service models - The SHAPE project: Supporting adults with High­functioning Autism and asPerger syndromE. Mapping and evaluating  Specialist Autism Team service models   
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Measurement of quality of life in carers of people with dementia - C-DEMQOL- Measurement of quality of life in family carers of people with  dementia: development of a new instrument for evaluation   
 Mechanisms of Regulation of Vascular Function - Mechanisms of Regulation of Vascular FunctionClosedInterventionalN/A
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 MROC: MR in Ovarian Cancer - The Impact of Multiparametric MRI on the Staging and Management of Patients with Suspected or Confirmed Ovarian Cancer.In Set-Up Pending NHS Permission  
 NCAAPS - Neuroscience Clinical Adolescent and Adult Psychiatry Study  (NCAAPS): Multi-site studies of atypical and abnormal neurocognition in individuals with mental illnesses aged 14-­24 years   
 Negative Pressure Therapy Wound Healing - NEPTUNE; Version 1.0 - Negative Pressure Therapy Wound Healing (NEPTUNE): a pilot randomised controlled trial comparing negative pressure wound therapy and usual care for surgical wounds healing by secondary intention.In Set-Up Pending NHS PermissionInterventional 
 New Biomarkers of Early Myocardial Infarction - Characterising Novel and Discovering New Biomarkers of Early Myocardial InjuryIn Set-Up Pending NHS PermissionObservational 
 Oesophageal Squamous cell CARcinoma (OSCAR) study - Study to determine novel biomarkers for early diagnosis and to  inform therapeutic management of Oesophageal Squamous Cell  Dysplasia and Carcinoma (OSCAR)   
 Oxytocin in healthy relatives of frontotemporal dementia (Version 1) - Social cognition and empathy functioning in first-degree healthy relatives of frontotemporal dementia patients and its relation to physiological Oxytocin levelsIn Set-Up Pending NHS PermissionObservational 
 PACT­-G - The Paediatric Autism Communication Trial ­- Generalised   
 Pain management in people with dementia in care homes: feasibility - Pain management in people with dementia living in care homes:  feasibility pilot and audit   
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PARSIFAL I - A randomized, multicenter, openlabel, phase II trial to evaluate the efficacy and safety of palbociclib in combination with fulvestrant or letrozole in patients with HER2 negative, ER+ metastatic breast cancer.In Set-Up Pending NHS PermissionInterventional-unknown-
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 POSAG Trial: Prevalence of Obstructive Sleep Apnoea in Glaucoma - POSAG Trial: Prevalence of Obstructive Sleep Apnoea in Glaucoma Prospective observational controlled trial of the prevalence of obstructive sleep apnoea in patients with open­angle  glaucoma.In Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Preemptive paracetamol for postoperative pain - Preemptive paracetamol for postoperative pain: a randomised, double blind two way crossover trialIn Set-Up Pending NHS PermissionInterventionalNo
 Progression Evaluation in Glaucoma (PEG) - Progression Evaluation in Glaucoma (PEG): Progression of disease in patients newly diagnosed with glaucoma and glaucoma suspects  participating in the GATE studyIn Set-Up Pending NHS PermissionObservationalNo
 Psoriasis Clinic Quality Index - An Investigation of the user experience of patients attending out patient psoriasis clinics at the Royal Victoria Infirmary.In Set-Up Pending NHS PermissionObservational 
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 Qualitative Evaluation of Telephone Outreach for NHS Health Checks - Qualitative evaluation of telephone outreach to enhance uptake of NHS Health Checks in more deprived communities   
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR) - Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR)  Development of a rapid Point of Care Molecular assay for the  detection of carbapenem resistance genes in rectal swabs   
 Reading, Playing and Talking - How to promote children's language development using family­based shared book reading. Study A: Identifying language­boosting behaviours with children with language impairment   
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?In Set-Up Pending NHS PermissionObservational 
 REGENERATE (REP1 Gene Replacement Therapy) Trial: Version 1.0 - An open label Phase 2 clinical trial of retinal gene therapy for  choroideremia using an adeno-associated viral vector (AAV2) encoding Rab­escort protein 1 (REP1)In Set-Up Pending NHS PermissionInterventionalNo
 Renal MRI Feasibility Study in Patients with CKD and AKI - Using MRI ASL Techniques for Quantitative Measurement of Renal Haemodynamics and Structural Parameters in Acute Kidney Injury and Chronic Kidney Disease.In Set-Up Pending NHS PermissionObservational 
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Resolution of acute inflammation in autoimmune rheumatic disease - The innate and adaptive inflammatory response to intradermal e.coli  in patients with autoimmune rheumatic disease and healthy controls.   
 Retrospective case note review of enteral tube related issues (v1) - Hospital admissions for enteral tube related issues: retrospective case note review to determine frequency, reasons and risk factors.In Set-Up Pending NHS PermissionObservationalNo
 REVAKI­-2 - The Effect of Sildenafil (REVATIO®) on Post Cardiac Surgery Acute  Kidney Injury: A Randomised, Placebo-controlled Phase IIb Clinical Trial: The REVAKI­-2 Trial   
 Roflumilast Effects on the Chemotactic Capacity of Leukocytes in COPD - The effects of Roflumilast on the chemotactic capacity of leukocytes from COPD patientsIn Set-Up NHS Permission ReceivedInterventionalNo
 SAMSON trial - Self-Assessment Method for Statin side-effects Or Nocebo (SAMSON) trial.In Set-Up Pending NHS PermissionInterventional 
 SARON - Stereotactic ablative radiotherapy for oligometastatic non­small cell lung cancer.   A randomised phase III trial.   
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Simpler and Safer Deep Brain Stimulation for Parkinson’s Disease - Simpler and Safer Deep Brain Stimulation for Parkinson’s Disease   
 Sleep and Psoriasis survey - What is the frequency and nature of sleep disruption in a sample of people with psoriasis?In Set-Up Pending NHS PermissionObservationalNo
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 SoMOSA: Study of Mechanisms of Action of Omalizumab in Severe Asthma. - SoMOSA: Study of Mechanisms of Action of Omalizumab in Severe Asthma.Opennot specifiedNo
 Soul­-Deep II:The South London Diabetes and Ethnicity Phenotyping study - Soul-Deep II: the South London Diabetes and Ethnicity Phenotyping Study Phase II   
 STAMINA ­- MRI pathology and pelvic pain in athletes(version 1.0) - STAMINA: study of the association between MRI pathology and pelvic pain in athletesIn Set-Up Pending NHS Permission  
 Standing frames for children with Cerebral Palsy_v1 - Standing frames as part of postural management for children with  spastcity. What is the acceptability of a trial to determine the efficacy of standing frames?   
 STAR_PAC - A Phase 1B study repurposing ATRA as stromal targeting agent along with gemcitabine and nab­Paclitaxel for  pancreatic cancer (STAR_PAC)   
 Studying calcaneus microarchitecture with teriparatide treatment - Studying calcaneus microarchitecture with teriparatide treatment   
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 TEAM GB - TEAM GB: The Exercise and Gut Bacteria Study   
 testCW - should be ignored/deleted   
 The Brain Imaging In Dementia study (BRAIID) - Brain imaging in dementia (BRAIID): an observational longitudinal study to optimise image reporting in dementia clinical practice.In Set-Up NHS Permission ReceivedObservationalYes, within lead country only
 The relationship between tinnitus, hyperacusis and anxiety in children - A prospective investigation into the relationship between tinnitus, hyperacusis and anxiety in children aged 8-16 years in children attending a paediatric audiology department   
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The RP Genome Project - The UK Inherited Retinal Disease Consortium RP Genome ProjectIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The 3R Study - A randomised controlled trial to investigate the effect of structured  education on people at high risk of cardiovascular disease   
 Tissue metabolism and blood flow in critically ill patients - An observational study in critically ill patients of the relationship  between tissue blood flow and metabolism and their severity of  disease and outcomesIn Set-Up Pending NHS PermissionObservationalNo
 'Together’ promotion of healthy lifestyles - 'Together’ a European project related to the promotion of healthy  lifestyles to pregnant and lactating women.In Set-Up Pending NHS PermissionObservationalNo
 TROLLEY - Evaluation of a growth guiding construct vs. standard dual growing  rods and VEPTR for the treatment of early onset  scoliosis patients: A prospective multi­center cohort study with a matched historical control.   
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vascular Function in Obesity - Identification of cardiovascular changes in obesity using dynamic and static retinal vessel analysisIn Set-Up Pending NHS PermissionObservationalNo
 Visual processing patterns in neurodevelopmental disorders - Visual processing patterns in neurodevelopmental disordersOpenObservational 
 WEB-based Physiotherapy for people with Axial Spondyloarthritis - WEBBased Physiotherapy for People with Axial Spondyloarthritis: A Cohort Study (WEBPASS)In Set-Up Pending NHS PermissionInterventionalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  
 Whole-­genome sequencing of multidrug-­resistant organisms in ICU - Whole-genome sequencing to investigate colonisation and transmission of  multidrug-­resistant organisms on the  adult intensive care unit at Addenbrooke’s Hospital   
 Wireless Monitoring - Evaluation of a wireless monitoring systemIn Set-Up Pending NHS PermissionInterventionalNo
 Xenon lung imaging in COPD: a COPD Cohort substudy - Hyperpolarised xenon magnetic resonance imaging (Xe-129 MRI) lung imaging in COPDIn Set-Up NHS Permission ReceivedObservationalNo
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