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UKCRN Study Portfolio

Recently Added studies
Summary list of studies added recently but with incomplete data.

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ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 4AT validation study - The 4AT as a triage test for delirium: a validation study in acutely hospitalised older patientsIn Set-Up Pending NHS Permission  
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A Smart COPD-SPOC monitor for interactive management of COPD - A Smart Saliva-based Point-Of-Care biosensor for interactive management of Chronic Obstructive Pulmonary Disease: COPD-SPOC monitorIn Set-Up Pending NHS PermissionObservationalNo
 A 34­week Follow­up to: MK­0431A in Pediatric Patients with Type 2 Diabetes Mellitus - A 34­week Follow­ up to: A Phase III, Multicenter, Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the  Safety and Efficacy MK­0431A (A Fixed Dose Combination Tablet of  Sitagliptin and Metformin) in Pediatric Patients with Type 2 Diabetes Mellitus.   
 Acoustic analysis of nasal airflow in normal and abnormal subjects(V2) - Cross-sectional study establishing normal nasal airflow acoustic signature as a surrogate marker for nasal patency, in patients without known nasal disease or subjective nasal blockage,  attending ENT outpatient clinics at the Royal National Throat, Nose and Ear Hospital. Case­control study to allow comparison of patients with nasal airflow  acoustic signals with and without subjective nasal blockageIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 Adult onset type 1 - diabetes ­ the PROCEED study - An Exploratory Study to Develop a Supportive Programme of Care for Adult Onset - Type 1 Diabetes­ the PROCEED study.   
 A-­JOINT - A­JOINT -Assessing joint health in patients with mild to moderate  haemophilia.In Set-Up Pending NHS Permission  
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 AURORA. - AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.   
 Blindness registration in Scotland - Registrable partial sighted and blindness at first presentation in ScotlandOpenObservationalYes, within lead country only
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Bowditch revisited: defining the optimum heart rate range in CHF - Bowditch revisited: defining the optimum heart rate range in chronic heart failureIn Set-Up Pending NHS PermissionInterventionalNo
 BVMP (Binocular Vision In Monocular Pseudophakia) - A prospective randomised controlled trial to assess improved binocular visual function in young patients under-going monocular cataract surgery with a bifocal intraocular lens.OpenInterventional and ObservationalYes, within and outside lead country
 Canine Olfactory Detection of Human Urological Cancer - Canine olfactory detection of human urological cancer from the odour of human urine samplesIn Set-Up Pending NHS PermissionObservationalNo
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 CATCH: Parents and Carers ATtending A&E for CHildren with fever - Parents and carers attending A&E for children with fever: exploring healthcare seeking behaviour.In Set-Up Pending NHS PermissionObservationalNo
 Change in free vitamin D after high dose cholecalciferol - Change in free vitamin D after high dose cholecalciferol administered to vitamin D deficient postmenopausal women.In Set-Up Pending NHS PermissionInterventionalNo
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 COPD Breathing Record Study - An exploratory, observational clinical evaluation of the CRiL N­Tidal C data collector capnometer to collect breathing records in patients with  COPDIn Set-Up Pending NHS PermissionObservationalNo
 CUTHIVAC002 - A Phase I clinical trial to assess the safety and immunogenicity of HIV DNAC CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteersIn Set-Up Pending NHS PermissionInterventionalNo
 Dementia Core Outcome Set Study - Development of a core outcome set for people with dementia living at home in their neighbourhoods and communitiesIn Set-Up Pending NHS PermissionObservational 
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development of a PROM for Cardiac Rehabilitation - Development of a Patient-reported Outcome measure (PROM) for Cardiac RehabilitationIn Set-Up Pending NHS PermissionInterventionalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diabetic Foot Ulcer Prevention System (DFUPS) - An Innovative System for the Early Identification, Monitoring, Evaluation and Diagnosis of Diabetic Foot Ulcers   
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 DNAVAC 001 - DNAVAC001: A Phase 1 open labelled trial to optimise DNA vaccination for antibody inductionIn Set-Up Pending NHS PermissionInterventionalNo
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Effectiveness of Ripple mapping for atrial tachycardia ablation - A prospective multicentre study of effectiveness of Ripple mapping for atrial tachycardia ablationIn Set-Up Pending NHS Permission  
 Energy Expenditure Study Version 1.0 - Feasibility Study to Investigate the Energy Expenditure of Acute Spinal Cord Injured Patients at Different Stages of Rehabilitation   
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 Exercise to prevent shoulder problems (PROSPER) (V1.0) - Exercise to prevent shoulder problems in patients undergoing breast cancer treatment: The PRevention Of Shoulder ProblEms TRial (PROSPER)In Set-Up Pending NHS PermissionInterventionalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Fancostem-­Plerixafor & Filgrastim mobilisation in Fanconi Anaemia - Phase II clinical trial to evaluate safety and efficacy of mobilisation and collection of CD34+ cells after treatment with plerixafor and filgrastim in patients with Fanconi anaemia for subsequent transduction with a  lentiviral vector carrying the FANCA gene and reinfusion into the  patientIn Set-Up Pending NHS PermissionInterventional 
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 Function of novel lipids in skin disease - Function of novel lipids in skin diseaseIn Set-Up Pending NHS PermissionObservationalNo
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 Genetic Study of Neurocognitive Substrates in OCD - Genetic Study of Neurocognitive Substrates in Obsessive­Compulsive DisorderIn Set-Up Pending NHS PermissionInterventional and Observational 
 GENFI Manchester - GENFIIn Set-Up Pending NHS PermissionObservational 
 Girls Active - A cluster randomised controlled trial to investigate the effectiveness and cost-effectiveness of the 'Girls Active' interventionIn Set-Up Pending NHS PermissionObservationalNo
 GlucoCEST - Establishment of GlucoCEST MRI as a Biomarker in Cancer Translational StudyIn Set-Up Pending NHS PermissionInterventional 
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HGUS Study - A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/­ ifosfamide following surgery or in metastatic first line treatmentIn Set-Up Pending NHS Permission  
 Home testing of day and night closed loop with pump suspend feature - An open-label, multi-centre, randomised, single-period, parallel design study to assess the efficacy, safety, utility and psychosocial effect of 12 week day and night automated closed loop glucose control combined with pump suspend feature compared to sensor augmented insulin pump therapy in youth and adults with type 1 diabetes with sub-optimal glucose control under free living conditionsIn Set-Up Pending NHS PermissionInterventionalNo
 Human Factor and Usability Testing of A Binocular OCT System - A Prospective SingleSite NonInterventional Study to Evaluate Human Factors and Usability of Automated, Comprehensive Ocular Examination in Elderly and Visually Impaired Populations using a Prototype Binocular Optical Coherence Tomography SystemIn Set-Up Pending NHS PermissionObservational 
 Hypoxia gene signature as a biomarker in prostate cancer - Development and validation of a hypoxia gene signature as a biomarker of radioresistance in prostate cancerIn Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICARIS Trial - Impact on Caesarean Section Rates Following Injections of Sterile Water (ICARIS)In Set-Up Pending NHS PermissionInterventional 
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Impact and Evaluation of the BuRNTool - Impact and Evaluation of a Burns Risk Assessment of Neglect and Maltreatment in Children Tool. BuRNTool A multi centre studyIn Set-Up Pending NHS PermissionInterventional 
 Improving access to dementia services for minority ethnic elders - Improving access to UK dementia services for the South Asian minority ethnic population: development and pilot of an intervention.In Set-Up Pending NHS Permission  
 Improving clinical practice for babies with hearing loss - Improving clinical practice for babies with hearing lossIn Set-Up Pending NHS PermissionInterventional 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Kidney Injury after Major Surgery (KIMS) - Observational study of the long term outcomes of acute kidney injury after major surgeryIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 LAAOS III - Left Atrial Appendage Occlusion Study III (LAAOS III)In Set-Up NHS Permission ReceivedInterventionalYes, within and outside lead country
 LENTICOLF - Phase 1 study of lentiviralmediated COL7A1 gene-modified autologous fibroblasts in adults with recessive dystrophic epidermolysis bullosaIn Set-Up Pending NHS Permissionnot specified 
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 LOCATE - LOCATE: Localising Occult prostate Cancer metastases with Advanced imaging TEchniqueIn Set-Up Pending NHS PermissionObservational 
 Longitudinal Histories-Endometriosis PCCIU - Longitudinal History Patterns for Earlier Diagnosis of EndometriosisOpen  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 MISSION COPD - MISSION COPD -Modern Innovative SolutionS in Improving Outcomes iN ­COPD -A comparison of clinical outcomes before and after the MISSION COPD clinic.In Set-Up NHS Permission ReceivedObservationalNo
 MODEM - Monitoring of Dementia Using Eye MovementsIn Set-Up NHS Permission ReceivedObservationalYes, within lead country only
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 MRI cardiopulmonary metrics in pulmonary arterial hypertension - Reproducibility of Magnetic resonance imaging cardiopulmonary metrics in healthy volunteers and patients with pulmonary arterial hypertension – Implications for trial designIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Multimodality imaging of the aorta - Investigation into aortic structure and function using magnetic resonance imaging (MRI), computed tomography (CT) and position emission tomography (PET)In Set-Up Pending NHS Permission  
 Oxford UKR: Second decade outcome study - Oxford Unicompartmental Knee Replacement: Second decade  outcome study.In Set-Up Pending NHS PermissionObservationalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 Paired Biopsies in Lung Cancer - Paired Biopsies in Lung Cancer– A Pilot StudyIn Set-Up Pending NHS PermissionObservational-unknown-
 PARSIFAL I - A randomized, multicenter, openlabel, phase II trial to evaluate the efficacy and safety of palbociclib in combination with fulvestrant or letrozole in patients with HER2 negative, ER+ metastatic breast cancer.In Set-Up Pending NHS PermissionInterventional-unknown-
 Patient outcomes following complex musculoskeletal injury - A cohort study to assess patient outcomes following complex  musculoskeletal injury and how the rehabilitation pathway impacts on  their recoveryIn Set-Up Pending NHS Permission  
 Personalised cancer risk information to promote behaviour change - Exploring the potential for using personalised cancer risk information to promote behaviour changeIn Set-Up Pending NHS Permission  
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 Phase I/II study of gene­-modified WT1 TCR therapy in MDS & AML patient - A single arm Phase I/II study of the safety and efficacy of gene-modified WT1 TCR therapy in patients with myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML) with low blast counts failing to achieve an IWG defined response following azacitidine therapyIn Set-Up Pending NHS Permission No
 Physiotherapy provision in the UK for pulmonary hypertension patients - An investigation into the current physiotherapy provision in the United Kingdom (UK) for patients with pulmonary hypertension (PH)In Set-Up Pending NHS Permissionnot specified 
 Pinsite Infection In Circular Frames -­ PINS trial - A randomised controlled trial of a new daily skincare regimen for  lowering the incidence of pinsite infections following circular frame  surgeryIn Set-Up NHS Permission ReceivedInterventionalNo
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 PRAM'OH Study: Patient ­Reported and Assessment of Mothers' Oral Health - Self-­reported questionnaire and gum health investigations to  explore demographic, clinical and behavioural factors influencing the  link between gum disease and preterm birth in East London hospitalsIn Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Preventing Preterm Birth with Probiotics ­Pilot Randomised Trial - Preventing Preterm Birth with Probiotics ­Pilot Randomised Trial (PrePro)In Set-Up Pending NHS PermissionInterventional 
46012373Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 PRIM4641 - A method validation, single-period, open-label evaluation study to explore the sensitivity of a novel biosensor device (SenseWear® Armband Gecko) for measuring physical activity in subjects with COPD & AsthmaIn Set-Up Pending NHS Permission  
 PRIM4754 - Non-interventional study on Edoxaban treatment in routine clinical practice for patients with non valvular atrial fibrillationIn Set-Up Pending NHS PermissionInterventionalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 RAPSODI GD - Remote assessment of Parkinsonism supporting ongoing development of interventions in Gaucher's diseaseIn Set-Up Pending NHS PermissionObservationalNo
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?In Set-Up Pending NHS PermissionObservational 
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 RESPECT-21: evaluation of specialist cancer surgery reorganisation - Reorganising specialist cancer surgery for the 21st century: a mixed methods evaluation (RESPECT-21)In Set-Up Pending NHS PermissionObservational-unknown-
 RIVER Registry – RIVaroxaban Evaluation in Real life setting - Prospective, multicentre, international Registry of male and female patients newly diagnosed with Atrial Fibrillation and treated with  RivaroxabanIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Simvastatin as a neuroprotective treatment for moderate PD (PD STAT) - Simvastatin as a neuroprotective treatment for Parkinson's disease: a double­blind, randomised, placebo controlled futility study in patients of moderate severityIn Set-Up Pending NHS PermissionInterventional 
 Sleep and Psoriasis survey - What is the frequency and nature of sleep disruption in a sample of people with psoriasis?In Set-Up Pending NHS PermissionObservational 
 SNAP­HT trial development pilot study V2.0 - Self­-management of Postnatal anti­-hypertensive Treatment: SNAP­HT trial development pilot studyIn Set-Up Pending NHS PermissionInterventional 
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Targeted Radiotherapy for ALAmyloidosis –‘TRALA’ - A Phase I/IIa Study of Targeted Radiotherapy alone for Stem Cell Transplant Conditioning in Systemic AL AmyloidosisIn Set-Up Pending NHS PermissionInterventional-unknown-
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 testCW - should be ignored/deleted   
 The DIASTOLIC Study - Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular dysfunction:In Set-Up Pending NHS PermissionObservational 
 The INFECIR2 Albumin Prevention Study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.In Set-Up Pending NHS PermissionInterventionalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The MATE study - Treating neovascular age-related Macular Degeneration with Aflibercept: a pilot 24 month, multi-­centre randomized controlled trial comparing Standard Care with an individualised Treat and Extend regimen.In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 The microbial pathology of severe asthma - Heterogeneity of Asthma: a pilot study to investigate  its microbiome and how it relates to asthma severityIn Set-Up Pending NHS PermissionInterventionalNo
 The VISICORT Study - Adverse Immune Signatures and their Prevention in Corneal Transplantation (The VISICORT study)In Set-Up Pending NHS PermissionInterventionalNo
 Ticagrelor for prevention of tumour cell-induced platelet aggregation - Investigating Aspirin and Ticagrelor for the prevention of tumour cell-induced platelet aggregationIn Set-Up Pending NHS PermissionInterventionalNo
 Treatment side effects in adults with learning disability and epilepsy - Identifying treatment Side effects in adults with an Intellectual Disability and Epilepsy: Development of a PatientReported Outcome Measure (PROM) for identification of AntiEpileptic Drug (AED) side effects (SIDEPRO)In Set-Up Pending NHS PermissionObservationalNo
 True NTH UK – Post Surgical Follow up - True NTH UK – Post Surgical Follow upIn Set-Up Pending NHS PermissionObservational 
 Umbilical cord Cell Model of Inflammation and Disease - Regulation of the recruitment and migration of leukocytes during  inflammationIn Set-Up Pending NHS Permission  
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vascular Function in Obesity - Identification of cardiovascular changes in obesity using dynamic and static retinal vessel analysisIn Set-Up Pending NHS PermissionObservationalNo
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received
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