UK Clinical Research Network : Portfolio Database User Guide  
Welcome to the UK Clinical Research Network Study Portfolio  
UKCRN Study Portfolio


Recently Added studies
Summary list of studies added recently but with incomplete data.

< Amend search criteria

Export to Excel
ISRCTNAcronym & TitleStatusTypeOpen to additional sites
 (duplicate) PARO: Introduction and Participatory Action Research (FREGC 14-038) - A Participatory Action Research Project on the introduction, use and evaluation of PARO, the therapeutic robotic seal to residential and inpatient dementia care.OpenObservationalNo
 18F-Fluoride Assessment of Aortic Bioprostheses Durability and Outcomes - 18F-Fluoride Assessment of Aortic Bioprostheses Durability and OutcomesIn Set-Up Pending NHS Permission  
 4AT validation study - The 4AT as a triage test for delirium: a validation study in acutely hospitalised older patientsIn Set-Up Pending NHS Permission  
 A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with - A longitudinal study of adolescent outcomes and CU in a sample of clinically referred children with Attention deficit hyperactivity disorderOpenObservational 
 A multi-centred-study of the effectiveness of PEGASUS - A multi-centred study of the effectiveness of PEGASUS, an intervention to promote shared decision making about breast reconstructionIn Set-Up Pending NHS PermissionInterventional 
 A Smart COPD-SPOC monitor for interactive management of COPD - A Smart Salivabased PointOfCare biosensor for interactive management of Chronic Obstructive Pulmonary Disease: COPD-SPOC monitorIn Set-Up Pending NHS PermissionObservationalNo
 A study to evaluate the effect of solithromycin in COPD - A singlecentre, doubleblind, randomised, placebo-controlled, crossover study to evaluate the effect of solithromycin on airway inflammation in male and female patients with chronic obstructive pulmonary disease.In Set-Up Pending NHS PermissionObservationalNo
 A new approach for improving infant sleep-­sharing safety - Let's Talk About Sleep! A new approach for improving infant sleep­sharing safety: a feasibility studyIn Set-Up Pending NHS PermissionInterventionalNo
 A pragmatic trial of corticosteroid optimisation in severe asthma - A RANDOMISED PRAGMATIC TRIAL OF CORTICOSTEROID  OPTIMISATION IN SEVERE ASTHMA USING A COMPOSITE  BIOMARKER ALGORITHM TO ADJUST CORTICOSTEROID DOSE  VERSUS STANDARD CAREIn Set-Up Pending NHS PermissionInterventionalNo
 Acoustic analysis of nasal airflow in normal and abnormal subjects(V2) - Cross-sectional study establishing normal nasal airflow acoustic signature as a surrogate marker for nasal patency, in patients without known nasal disease or subjective nasal blockage,  attending ENT outpatient clinics at the Royal National Throat, Nose and Ear Hospital. Case­control study to allow comparison of patients with nasal airflow  acoustic signals with and without subjective nasal blockageIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 ACtiF - Adherence to treatment in adults with Cystic Fibrosis 2.2B - Full programme: Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis (ACtiF) This sub study 2.2B: A study to develop a Behaviour Change Intervention (BCI) to help patients with CF manage treatment adherence.In Set-Up Pending NHS PermissionInterventionalNo
 ADAM: Alcohol Dependence and Adherence to Medicine - A three-arm, Randomised Controlled Trial of the effectiveness and cost-effectiveness of adjunctive medication management and contingency management to enhance adherence to medications for relapse prevention in alcohol dependenceIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 ADHD in children with learning difficulties - ADHD in children with learning difficultiesOpenObservational 
 ADjuST study - Analgesic efficacy of high density spinal cord stimulation at 1 KHzIn Set-Up Pending NHS PermissionObservationalNo
 Adult onset type 1 - diabetes ­ the PROCEED study - An Exploratory Study to Develop a Supportive Programme of Care for Adult Onset - Type 1 Diabetes­ the PROCEED study.   
 AFTER - Aggression Following TBI: Effectiveness of RisperidoneIn Set-Up Pending NHS PermissionInterventionalNo
 ALIFE 2 - Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia : ALIFE 2In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Anti-angiogenic agent in neuroblastoma - Assessment of therapeutic potential of a new anti-angiogenic agent in neuroblastomaIn Set-Up NHS Permission Received  
 Antiplatelet therapy in COPD (APPLE-COPD:ICON 2) - Anti-platelet Therapy in the Primary Prevention of Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease.In Set-Up Pending NHS PermissionObservationalNo
 BFT with People with Learning Disabilities - Behavioural Family Therapy with People with Learning Disabilities: A Feasibility StudyOpenObservationalNo
 BLIS - Barriers to life style interventions in schizophreniaIn Set-Up Pending NHS Permission  
 Can MR-proADM improve prediction of outcome in acutely ill patients? - The clinical utility of a risk assessment tool combining NEWS (National Early Warning Score) and mid-­regional pro-adrenomedullin (MR­proADM) for the disposition planning of acutely ill patientsIn Set-Up Pending NHS PermissionObservationalNo
 CapaCiTY Study 2 - Chronic Constipation Treatment Pathway - PRAGMATIC RANDOMISED TRIAL OF LOW VERSUS HIGH VOLUME INITIATED TRANSANAL IRRIGATION THERAPY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventionalNo
 CapaCiTY Study 3-Chronic Cinstipation Treatment Pathway - STEPPED WEDGE RANDOMISED TRIAL OF LAPAROSCOPIC VENTRAL MESH RECTOPEXY IN ADULTS WITH CHRONIC CONSTIPATIONIn Set-Up Pending NHS PermissionInterventional and ObservationalYes, within lead country only
 CATALyST - Neighbourhood determinants of the common mental disorders: the Caerphilly Health and Social Needs Longitudinal StudyOpen  
 CATCH: Parents and Carers ATtending A&E for CHildren with fever - Parents and carers attending A&E for children with fever: exploring healthcare seeking behaviour.In Set-Up Pending NHS PermissionObservationalNo
 CIST full study - Spectral mammography for lesion characterization: (Characterization using Imaging with Spectral mammography of Tissue – CIST study)In Set-Up Pending NHS Permission  
63375144CLARET - CLL Levels following Alemtuzumab in Responders to Earlier Therapy: A randomised phase III study to assess alemtuzumab consolidation therapy in patients with CLL who have responded to previous therapy.In Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 Clinical decision making on the ward round - An ethnographic study investigating intra- and inter- disciplinary team dynamics in antimicrobial decision making on the ward roundIn Set-Up Pending NHS PermissionObservational 
 Clinical validation of the Dystonia NMS Questionnaire (DNMS Quest) - Clinical validation of the Dystonia NMS Questionnaire (DNMS Quest) in patients with primary dystoniaIn Set-Up Pending NHS PermissionObservational 
 Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: develo - Cognitive and neurobiological mechanism leading to psychotic traits in adolescents with ADHD: developing an evidence base for intervention strategiesIn Set-Up Pending NHS Permission  
 Comparison of Ostomy Products (COOP) - A randomised-controlled double-blind crossover comparison of Manuka honey hydrocolloid (Aurum®) versus conventional hydrocolloid (Optum®) on peristomal skin health.In Set-Up Pending NHS PermissionObservationalNo
 Complementary therapies and supportive care - Research Proposal: Complementary therapies and supportive cancer care: towards integration and holistic care? A qualitative study of patients and professionalsIn Set-Up NHS Permission Received  
 CONCEPTT substudy - A Feasibility Study Examining the Relationship between Autonomic Neuropathy and Severe Maternal Hypoglycaemia in Type 1 Diabetes during PregnancyIn Set-Up Pending NHS Permission  
 COPD Breathing Record Study - An exploratory, observational clinical evaluation of the CRiL N­Tidal C data­collector capnometer to collect breathing records in patients with  COPDIn Set-Up Pending NHS PermissionObservationalNo
 CUTHIVAC002 - A Phase I clinical trial to assess the safety and immunogenicity of HIV DNAC CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteersIn Set-Up Pending NHS PermissionObservationalNo
 DECIDE and SHARE-IT: shared decision making - Development of generic decision aids linked to recommendations in GRADE guidelines to promote shared decision making in the clinical encounter: user-testing and feedbackIn Set-Up Pending NHS Permission  
 Dementia Core Outcome Set Study - Development of a core outcome set for people with dementia living at home in their neighbourhoods and communitiesIn Set-Up Pending NHS PermissionObservational 
 Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disabilit - Detecting chromosomal anomalies with attention deficit hyperactivity disorder and learning disability using microarray based comparative genomic hybridisationOpenObservational 
 Development and Evaluation of a Neurorehabilitation Outcomes Database - Development and Evaluation of a Neurorehabilitation Outcomes DatabaseOpenObservationalNo
 Development of a PROM for Cardiac Rehabilitation - Development of a Patient-reported Outcome measure (PROM) for Cardiac RehabilitationIn Set-Up Pending NHS PermissionInterventionalNo
 Development of a tumour radiosensitivity-associated gene expression signature - Development of a tumour radiosensitivity-associated gene expression signatureClosed N/A
 Diabetes 001 (LRN East) - Influence of maternal glucose tolerance in pregnancy on parity-related and normal variation in size at birth; investigation of genetic determinantsIn Set-Up Pending NHS PermissionObservationalNo
 Diabetes 019 (LRN NWLon) - A trial to compare the effects of nebivolol versus atenolol on various cardiovascular measurements including insulin sensitivityClosed N/A
 Diabetic Foot Ulcer Prevention System (DFUPS) - An Innovative System for the Early Identification, Monitoring, Evaluation and Diagnosis of Diabetic Foot Ulcers   
 DIADS - Diagnostic Instruments for Austim in Deaf children Study – Validation of Autism Assessment Instruments for deaf childrenIn Set-Up NHS Permission ReceivedObservationalNo
 Diagnosing and monitoring infection in critical illness - Diagnosing and monitoring infection in critically ill patients using metabolic and immunological signaturesIn Set-Up Pending NHS PermissionObservationalNo
 Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a n - Disentangling genetic, intrauterine and environmental factors on childhood psychopathology using a novel methodOpenObservational 
 Early predictor of violence - Early predictor of violenceOpenObservational 
 EaStER Main trial - EaStER: Early Stage Glottic Cancer: Endoscopic Excision or Radiotherapy?Suspended Yes, within and outside lead country
 Educating adolescents at Risk of Anaphylaxis and their Future Doctors - Educating adolescents at Risk of Anaphylaxis and their Future Doctors (ERA+FD)In Set-Up Pending NHS PermissionObservationalNo
 Effects of dietary nitrate in hypertensive pregnant women (version 1) - Feasibility study on the effects of dietary nitrate on cardiovascular  function in hypertensive pregnant womenIn Set-Up Pending NHS PermissionInterventionalNo
 Electrical Impedance Tomography of brain function - Imaging Stroke, Epilepsy and Evoked Potentials in the brain using Electrical Impedance TomographyIn Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 ENRICH Ibrutinib for untreated mantle cell lymphoma - Randomised, open label study of rituximab/ibrutinib vs rituximab/chemotherapy in older patients with untreated mantle cell lymphomaIn Set-Up Pending NHS PermissionInterventional 
 Epigenetic biomarkers in HNSCC - Epigenetic biomarkers in Head and Neck Squamous Cell Carcinoma surgical margin analysisIn Set-Up NHS Permission Received  
 Equivalence in analgesic efficacy & bowel function taking OXN tablets - A randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/ 40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy.   
 Exome Sequencing to Discover new causative genes for TAAD - Discovery and Impact of New Causative Genes for TAAD (Thoracic Aortic Aneurysm and Dissection)In Set-Up Pending NHS PermissionObservationalNo
 Family and Population Genetic Studies in Mental Illness 2 - Family and Population Genetic Studies in Mental Illness 2In Set-Up Pending NHS Permission  
 Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS) - Feasibility study of psychopathology in children with 22Q11 deletion syndrome (22Q11DS)In Set-Up Pending NHS Permission  
 Focus Group for Envisage Project - Focus group with participants from the Envisage Project to inform future use of biomechanical visualisations in stroke rehabilitationIn Set-Up Pending NHS Permission  
 GAN Cymru - Collaborative study to identify genes associated with susceptibility to anorexia nervosaOpenObservational-unknown-
 GARMIN-II: double-blind randomised controlled trial of lesogaberan in cough - The Role of GABAb receptor mechanisms in cough: Double-blind randomised controlled trial of Lesogaberan in Chronic cough patients with positive and negative symptom association probabilitiesIn Set-Up Pending NHS PermissionInterventionalNo
 Genetic dissection of the mood-psychosis spectrum - Genetic dissection of the mood-psychosis spectrumOpenObservational 
 Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disord - Genetic susceptibility to a deficit in contextual processing across the schizophrenia/bipolar disorder diagnostic divideIn Set-Up NHS Permission Received  
 GENFI Manchester - GENFIIn Set-Up Pending NHS PermissionObservational 
 GOG-0242 - A PHASE II STUDY TO DETERMINE THE RESPONSE TO SECOND CURETTAGE AS INITIAL MANAGEMENT FOR PERSISTENT LOW RISK, NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASIAIn Set-Up NHS Permission Received  
 GSAO - A Phase I trial of intravenous GSAO (Protocol PH1/109)In Set-Up NHS Permission Received  
 HAPO FAMILY - HAPOIn Set-Up Pending NHS Permission  
 Hepatitis C virus transmission networks in Glasgow - Hepatitis C virus transmission networks in GlasgowIn Set-Up Pending NHS Permission  
 HGUS Study - A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/­ ifosfamide following surgery or in metastatic first line treatmentIn Set-Up Pending NHS Permission  
 How human thymic epithelial cells shape selfantigen - How human thymic epithelial cells shape selfantigen diversityIn Set-Up Pending NHS PermissionInterventional 
 Hypoxia gene signature as a biomarker in prostate cancer - Development and validation of a hypoxia gene signature as a biomarker of radioresistance in prostate cancerIn Set-Up Pending NHS PermissionObservationalNo
 HYPREL - A feasibility study of relaxation therapy plus autohypnotherapy (HYPREL) for patients with thoracic cancer undergoing radiotherapyIn Set-Up NHS Permission Received  
 ICON3 p53 - Evaluation of p53 mutation as a predictive factor in outcome to chemotherapy in ovarian cancer. (“ICON3 p53 study”)In Set-Up NHS Permission Received  
 Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate - Identifying susceptibility genes for ADHD with antisocial behaviour as a covariateIn Set-Up Pending NHS Permission  
 IELSG 42 - Marietta - An international phase II trial assessing tolerability and efficacy of sequential MethotrexateAracytinbased combination and RICE combination, followed by high-dose chemotherapy supported by autologous stem cell transplant, in patients with systemic B-cell lymphoma with central nervous system involvement at diagnosis or relapse (MARIETTA regimen)In Set-Up Pending NHS PermissionInterventional 
 IELSG10 - A phase II study of CHOP, Rituximab, intrathecal methotrexate followed by radiotherapy in patients with primary testicular Non-Hodgkin's LymphomaClosed N/A
 IM-CAT - Immunotherapy for squamous cell carcinoma of the head and neck by TransimmunizationIn Set-Up NHS Permission ReceivedInterventionalYes, within lead country only
 IMRiS - A phase II study of intensity modulated radiotherapy (IMRT) in primary bone and soft tissue sarcomaIn Set-Up Pending NHS PermissionInterventional 
 Innovate Dementia Acorn Project - An evaluation of the impact of intelligent lighting in an in-patient environment for people living with dementiaIn Set-Up Pending NHS PermissionObservational 
 INPIC Pilot: Cordotomy - The role of cordotomy in the management of mesothelioma-related pain in the United KingdomIn Set-Up NHS Permission Received  
 Intellatip MiFi Catheter to Optimise Left Atrial Ablation & Mapping - The Utilisation of the Intellatip MiFi Open Irrigation Catheter to Optimise AF Ablation & Mapping of Atrial Arrhythmias.In Set-Up Pending NHS PermissionObservationalNo
 Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in bir - Investigating genetic and environmental risk factors for sub-clinical psychosis like symptoms in birth cohort studyOpenObservational 
 Kidney Injury after Major Surgery (KIMS) - Observational study of the long term outcomes of acute kidney injury after major surgeryIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Leukapheresis of white cells from patients with CLL for gene therapy - Leukapheresis of white cells from patients with Chronic Lymphocytic Leukaemia to develop immunotherapy approaches using genetically modified T cellsIn Set-Up Pending NHS Permission  
 Living with RDEB - Living with Recessive Dystrophic Epidermolysis Bullosa (RDEB)In Set-Up Pending NHS PermissionObservationalNo
 LOCATE - LOCATE: Localising Occult prostate Cancer metastases with Advanced imaging TEchniqueIn Set-Up Pending NHS PermissionObservational 
 Long term abdominal drains in end stage cirrhosis - Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis : a feasibility randomised controlled trial.In Set-Up Pending NHS PermissionObservationalNo
 Longitudinal Histories-Endometriosis PCCIU - Longitudinal History Patterns for Earlier Diagnosis of EndometriosisOpen  
 LYDO (Thome) - A Long Term Study of a Medication for Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)OpenInterventional 
 MARCHON - A randomised 3-arm trial of modestly accelerated radiotherapy alone or with either synchronous nimerazole or synchronous cisplatinum chemotherapyClosed N/A
 MBCT for social anxiety in visible skin conditions - The effectiveness of mindfulness based cognitive group therapy for  social anxiety symptoms in people living with visible skin conditions: A case series of a group interventionIn Set-Up Pending NHS PermissionObservationalNo
 Metabolomics in SLE - Pilot study on the use of metabolomics to predict outcome in patients with systemic lupus erythematosusIn Set-Up Pending NHS PermissionObservationalNo
 Methotrexate induced liver fibrosis - Evaluation of the role of AST:ALT ratio, ELF markers and fibroscan in the detection of methotrexate induced hepatotoxicity.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Microanatomical correlation - Microanatomical correlation between dynamic MRI and histopathology in women with operable breast cancerIn Set-Up NHS Permission Received  
 MINI - A MINI perspective: needs assessment for common mental disorders in primary care.OpenObservationalNo
 MODEM - Monitoring of Dementia Using Eye MovementsIn Set-Up NHS Permission ReceivedObservationalYes, within lead country only
 Molecular genetic studies of schizophrenia - Molecular genetic studies of schizophreniaOpenObservational 
 MRI cardiopulmonary metrics in pulmonary arterial hypertension - Reproducibility of Magnetic resonance imaging cardiopulmonary metrics in healthy volunteers and patients with pulmonary arterial hypertension – Implications for trial design   
 Multimodality imaging of the aorta - Investigation into aortic structure and function using magnetic resonance imaging (MRI), computed tomography (CT) and position emission tomography (PET)In Set-Up Pending NHS Permission  
 NEST: NMDA-receptors in Epilepsy, Stroke and TBI - NEST: NMDA receptor binding in focal Epilepsies, Stroke and Traumatic brain injury patients at risk of developing epilepsyIn Set-Up Pending NHS PermissionObservationalNo
 NMDA PET in TBI - Imaging NMDA receptor activation following head injury using positron emission tomographyIn Set-Up Pending NHS PermissionObservationalNo
 Non-Invasive Brain Stimulation in Stroke Patients (NIBS) - A Randomised Trial of Non-Invasive Brain Stimulation (NIBS) in Stroke SurvivorsIn Set-Up Pending NHS Permission  
 OARS­ - The Outcomes in Ankle Replacement Study - The Outcomes in Ankle Replacement Study (OARS): A study of  patient reported outcomes following total ankle replacement based on data from the National Joint Registry for England and WalesIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 OatMet version 2 - The effect of oat processing on gastric emptying and satiety induced after consuming porridge.In Set-Up Pending NHS PermissionInterventionalNo
 Oxford UKR: Second decade outcome study - Oxford Unicompartmental Knee Replacement: Second decade  outcome study.In Set-Up Pending NHS PermissionObservationalNo
 Pain_OMICs - Pain_Omics - a prospective study to identify biomarkers involved in the transition from acute to persistent chronic low back painIn Set-Up Pending NHS Permission  
 PanCareLife fertility study of female childhood cancer survivors v2 - Fertility impairment in a Pan­-European cohort of female 5­year survivors of childhood cancer: PanCareLife studyIn Set-Up Pending NHS PermissionObservationalNo
 Patients' views of discussing weight management with knee OA V1.15.1.15 - To understand patients’ views and experiences of discussing weight management with a health professional when they have a clinical diagnosis of knee osteoarthritis and a BMI of over 25.In Set-Up Pending NHS PermissionObservationalYes, within and outside lead country
 Phase II trial of PR1 and WT1 peptides in Chronic Myeloid Leukaemia - A Cancer Research UK Phase II immunotherapy study of PR1169 and WT1126 peptide vaccines plus GMCSF and imiquimod given alongside second line therapy with nilotinib versus nilotinib therapy alone in patients with Chronic Myeloid Leukaemia (CML) molecularly positive for BCRABL transcript.Closed N/A
 PhenoDM1 - Myotonic Dystrophy type 1 (DM1) deep phenotyping to improve delivery of personalised medicine and assist in the planning, design and recruitment of clinical trials.In Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Physiotherapy in Conservatively Managed Distal Radius Fractures - Outcomes and Cost Effectiveness of Physiotherapy, Self Directed Therapy and Advice Sheets Following Conservatively Managed Distal Radius Fractures : A Prospective Randomised Controlled Trial.In Set-Up Pending NHS PermissionObservationalNo
 Pinsite Infection In Circular Frames -­ PINS trial - A randomised controlled trial of a new daily skincare regimen for  lowering the incidence of pinsite infections following circular frame  surgeryIn Set-Up NHS Permission ReceivedInterventionalNo
 PIONEER Study - PIONEER: A Phase I Study of Olaparib in Combination with Chemoradiation in Locally Advanced Pancreatic Cancer   
 Planning and Evaluation Methodologies for Mental Healthcare Buildings - 'PEMETH': Planning and Evaluation Methodologies for Mental Healthcare BuildingsIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Platelet function in paediatric cardiac patients on bypass and ECMO - Platelet function in paediatric cardiac patients on bypass and ECMOIn Set-Up Pending NHS PermissionObservationalNo
 Predicting and preventing adolescent depression - Predicting and preventing adolescent depressionOpenObservational 
 Predicting response to disease modifying treatments in MS - Predicting response to disease modifying treatments for multiple sclerosisIn Set-Up NHS Permission ReceivedObservational 
 Predicting poor outcome following total hip and knee arthroplasty - A prospective observational (C) study in adult patients with primary osteoarthritis (P), to identify the physical and psychological risk factors predicting poor patient satisfaction and function (O) following primary total hip and knee arthroplasty (I) I ­Intervention, P ­Population,  O Outcome, C ­ ComparatorOpenObservationalNo
46012373Prevention of morbidity in sickle cell disease: phase II (POMS 2b) - Prevention of morbidity in sickle cell disease Phase II (Improvement of Pain and Quality of Life in Patient with Sickle Cell Disease with Autoadjusting Continuous Positive Airways Pressure: Phase II) (POMS 2b)In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 PRIM4641 - A method validation, single-period, open-label evaluation study to explore the sensitivity of a novel biosensor device (SenseWear® Armband Gecko) for measuring physical activity in subjects with COPD & AsthmaIn Set-Up Pending NHS Permission  
 PRIM4754 - Non-interventional study on Edoxaban treatment in routine clinical practice for patients with non valvular atrial fibrillationIn Set-Up Pending NHS PermissionInterventionalNo
 PRODIGY (Definitive RCT) - PRODIGY: Prevention of long term social disability amongst young people with emerging psychological difficulties: a definitive randomised controlled trial of social recovery cognitive behavioural therapyIn Set-Up Pending NHS PermissionInterventionalNo
 Protein defects in retinal degenerations (version 0.9) - Investigation of protein defects in inherited retinal degenerationsIn Set-Up Pending NHS PermissionObservationalNo
 Proteomics of diabetic macular oedema and retinal vein occlusion - A comparative proteomic approach to identify novel biomarkers for  diabetic macular oedema and retinal vein occlusionIn Set-Up Pending NHS PermissionObservationalNo
 PTLD1 - Title to be confirmedIn Set-Up NHS Permission Received Yes, within and outside lead country
 RACE - A prospective Randomized multicenter study comparing horse Antithymocyte globuline (hATG) + Cyclosporine A (CsA) with or without Eltrombopag as front-line therapy for severe aplastic anemia patients.In Set-Up Pending NHS PermissionInterventional 
 RADIOLOGIC - Definitive Chemoradiotherapy with the Addition of Lapatinib in Inoperable, Locally Advanced Oesophageal and OGJ Adenocarcinoma A Phase I studyClosedInterventionalN/A
 Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorder - Randomised controlled trial of cortisol versus placebo for chronic post traumatic stress disorderIn Set-Up Pending NHS Permission  
 Reduced habitual intrusions: an early marker for Parkinson's disease? - Reduced habitual intrusions: an early marker for Parkinson's disease?In Set-Up Pending NHS PermissionObservational 
 Representing Communities: Hodgehill - Representing Communities: Developing the creative power of people to improve health and well-beingIn Set-Up Pending NHS Permission  
 Repurposing anti-TNF for treating Dupuytren's disease - A multicentre, double blind, randomised, placebocontrolled, parallel group, phase II trial to determine the safety and efficacy of intranodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with a dose response run-in.In Set-Up Pending NHS PermissionObservationalNo
 Research on the impact of NSCLC on caregivers' quality of life - Caregiver Interviews to Understand the Disease Experience and Impact of Non-­Small Cell Lung Cancer on Quality of Life   
 Retention of CD16+ monocytes in the ischaemic limb - The Retention of Angiogenic CD16+ Monocytes in Critical Limb Ischaemia (ROAM­CLI)   
 Risk factors for colorectal precursor lesions - Risk factors for colorectal cancer in individuals’ with a colorectal precursor lesionIn Set-Up Pending NHS PermissionObservational 
 RIVER Registry – RIVaroxaban Evaluation in Real life setting - Prospective, multicentre, international Registry of male and female patients newly diagnosed with Atrial Fibrillation and treated with  RivaroxabanIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Rowing Away from Diabetes - Indoor rowing in adults with impaired glucose regulation: a pilot study   
 Sched3 - Assessment of post booster antibody responses in UK infants given a reduced priming schedule of meningococcal serogroup B and 13 valent pneumococcal conjugate vaccinesClosedInterventionalN/A
 SIBS - A Genetic Study of Quantitative Phenotypes Related to Breast CancerIn Set-Up NHS Permission Received  
 Size of sepsis in Wales - Size of sepsis in WalesOpenObservationalNo
62865905SOB-LC - A randomised trial of high vs low intensity training in breathing techniques for breathlessness in patient with malignant lung disease: a feasibility studyClosedInterventionalN/A
 Social and Personal Constructs of Dementia - Social and Personal Constructs of DementiaOpenObservationalYes, within lead country only
 Sound feedback and body image in Complex Regional Pain Syndrome - A study using sound feedback for enhancing bodily feelings and  emotional state in patients with Complex Regional Pain Syndrome  Type 1.In Set-Up Pending NHS PermissionObservationalNo
 SSAT063­-PK of EFV 400mg once daily during pregnancy in HIV+ women - SSAT063; Pharamcokinetics of efavirenz 400mg once daily during  pregnancy in HIV­-1 infected womenIn Set-Up Pending NHS PermissionInterventionalNo
 Stem Cell Therapy for the Treatment of Congenital Heart Disease - Stem Cell Therapy for the Treatment of Congenital Heart Disease: Mending the Youngest HeartIn Set-Up Pending NHS PermissionInterventional and Observational 
12472821Study examining the effect of Etanercept on inflammation in the brain - A double-blind, placebo-controlled study of the effect of a TNF alpha inhibitor, etanercept (Enbrel), on microglial activation in amyloid PET positive patients with Mild Cognitive Impairment due to AD-Intermediate likelihoodIn Set-Up Pending NHS PermissionInterventionalNo
 Surgery and Alzheimer's pathology - Evaluating the influence of obesity on neuroinflammation and Alzheimer’s pathologyIn Set-Up Pending NHS PermissionObservationalNo
 Tau PET in traumatic brain injury - Assessing tau levels after Traumatic Brain Injury (TBI) using [18F]T807 Positron Emission Tomography (PET).In Set-Up Pending NHS PermissionInterventional 
 Test And Detect Antibodies in HPV unvaccinated women Study­-2 - Test And Detect Antibodies in HPV unvaccinated women (TADAH-2) StudyIn Set-Up Pending NHS PermissionInterventionalNo
 Testing Arthritis Gloves in Rheumatoid/ Inflammatory Arthritis - The effects of arthritis gloves on people with Rheumatoid Arthritis or  Early Inflammatory Arthritis with hand pain: a multicentre-randomised controlled trialIn Set-Up Pending NHS PermissionInterventionalNo
 The EYE project – Process evaluation - Improving Engagement in Early Interventions: A pilot study adopting young psychosis service user and carer perspectives to shape EIP Services in the South East for patient benefit – Process evaluationOpenObservationalNo
 The in vivo migration and micromotion of the TriFit TS femoral stem - Investigation of the invivo migration and micromotion in the Corin TriFit TS femoral hip system using Radiostereometric Analysis (RSA)In Set-Up Pending NHS PermissionObservationalNo
 The INFECIR2 Albumin Prevention Study - Albumin administration in the prevention of hepatorenal syndrome and death in patients with cirrhosis, bacterial infections other than spontaneous bacterial peritonitis and high risk of hospital mortality.In Set-Up Pending NHS PermissionObservationalNo
 The PRACTICE Trial - Pulmonary Rehabilitation and ACTIvity after COPD Exacerbation - The PRACTICE TrialIn Set-Up Pending NHS PermissionObservationalNo
 The role of Nm23-H1 as a haemopoietic stem cell survival factor - The role of Nm23-H1 as a haemopoietic stem cell survival factor and its implications for leukaemiaIn Set-Up Pending NHS PermissionObservational 
 The TARGET Trial - A Phase I study of a chemotherapy doublet (Gemcitabine plus Capecitabine-GemCap) combined with a biologic doublet (Bevacizumab plus Erlotinib) in patients with advanced pancreatic adenocarcinoma (PC): the TARGET TrialIn Set-Up NHS Permission Received  
 The MATE study - Treating neovascular age-related Macular Degeneration with Aflibercept: a pilot 24 month, multi-­centre randomized controlled trial comparing Standard Care with an individualised Treat and Extend regimen.In Set-Up Pending NHS PermissionInterventionalYes, within lead country only
 Time for Dementia (TFD) - Time for Dementia: Evaluation of a novel multi-professional longitudinal clerkship in dementiaIn Set-Up Pending NHS PermissionObservationalNo
 Trans­-venous occlusion of pelvic vein incompetence - TRANS-­VENOUS OCCLUSION OF INCOMPETENT PELVIC VEINS AS A TREATMENT FOR CHRONIC PELVIC PAIN IN WOMEN: A RANDOMISED CONTROL TRIALIn Set-Up Pending NHS PermissionInterventional 
 True NTH UK – Post Surgical Follow up - True NTH UK – Post Surgical Follow upIn Set-Up Pending NHS PermissionObservational 
 Understanding the experiences of people with major stroke - Understanding the experiences and multidimensional needs of people with major stroke: a mixed methods studyIn Set-Up Pending NHS Permission  
 Understanding the nature of inhibitors in haemophilia - Understanding the nature of inhibitors in haemophiliaIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 URICA - Evaluating urinary carbonic anhydrase II (CAII) excretion as a fast, simple and economical means of diagnosing haemolysis in newborns under minimal-laboratory conditions.In Set-Up Pending NHS PermissionObservational 
 V1: Development of a PRO Measure in Haematological Practice - The Conceptualisation, Development and Validation of a Treatment-Related Patient-Reported Outcome Measure in Haematological Malignancies for Use in Clinical PracticeIn Set-Up Pending NHS PermissionObservational 
 Validating the MSKHQ - Validating the Arthritis Research UK Musculoskeletal Health Questionnaire (MSKHQ).OpenObservationalNo
 Validation of alcohol screening instruments in primary care - Alcohol Use Disorders Identification Test (AUDIT) and a shortened version (AUDITC) as screening instruments for identfication of excessive drinking: validation in a primary care population in EnglandIn Set-Up Pending NHS Permission  
 Vascular Function in Obesity - Identification of cardiovascular changes in obesity using dynamic and static retinal vessel analysisIn Set-Up Pending NHS PermissionObservationalNo
 Vibrant Effectiveness and Reliability Study (VERS) - Evaluating the long-term reliability and performance of the Vibrant Soundbridge and Bonebridge systemsIn Set-Up Pending NHS PermissionObservationalYes, within lead country only
 Welsh BDI study - Translation and Validation study of a Welsh Language Version of the Beck Depression Inventory-II.In Set-Up NHS Permission ReceivedObservational-unknown-
 Which outcomes related to RCT informed consent matter to stakeholders? - EvaLuation of Interventions for informed Consent for randomIsed controlled Trials (ELICIT): protocol for a systematic review of the literature and identification of a core outcome set using a Delphi surveyIn Set-Up Pending NHS Permission  
 White Matter Mapping (06RP01) - White Matter Mapping for Improved Characterisation and Neurosurgical Planning of Brain TumoursIn Set-Up NHS Permission Received  




public.ukcrn.org.uk/search
If you experience problems using the application, please click here.