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| NB: The information displayed below does not replace the protocol. The latest protocol version should always be consulted before making clinical decisions. |
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DRN 023 ASCEND
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ASCEND : A randomised 2x2 factorial study of aspirin versus placebo, and omega-3 fatty acid supplementation versus placebo, for primary prevention of cardiovascular events in people with diabetes
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Topic
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Diabetes (co-adopted by PCRN)
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Portfolio Eligibility
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Funded by UKCRC partner
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ISRCTN
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60635500
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EudraCT
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2004-000991-15
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MREC N° |
MREC 03/8/087
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UKCRN ID |
2257
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WHO ID
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Research Summary
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The aim of ASCEND is to determine whether 100mg daily aspirin and/or supplementation with 1g omega-3 fatty acids daily prevents cardiovascualr events in patients who do not already have clinically manifest areterial disease, without leading to significant bleeding or other adverse events.
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Study Type |
Interventional
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Design Type |
Treatment
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Disease(s) |
Cardiovascular disease
All Diseases
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Phase |
IV
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Current Status
| Open |
| Closure Date | 31/12/2010 |
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Sample Size
| 15000 |
| Accrual to Date |
 71% |
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Geographical Scope
| UK Multi-Centre |
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Lead Country
| England |
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Open to new sites
| Yes, within and outside lead country |
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Main Inclusion Criteria
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Inclusion Criteria:
Men and women with diabetes (Type 1 or 2)
Age >= 40 years with no previous history of vascular disease
No clear contra-indication to aspirin
No other predominant life-threatening medical problem (e.g. cancer)
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Main Exclusion Criteria
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Exclusion Criteria:
Definite history of myocardial infarction, stroke or arterial revascularisation procedure
Clear indication for aspirin, warfarin or any other blood thinning medication
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Chief Investigator(s)
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| Dr Jane Armitage |
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Further details, please contact
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Dr Louise Bowman
University of Oxford
ASCEND
Clinical Trial Service Unit
Richard Doll Building
Old Road
Headington
Oxford
Oxfordshire
OX3 7LF
UNITED KINGDOM
Tel: 01865 743875
louise.bowman@ctsu.ox.ac.uk
| Lucy Fletcher
University of Oxford
Old Road
Headington
Oxford
Oxfordshire
OX3 7LF
UNITED KINGDOM
Tel: 01865 743888
lucy.fletcher@ctsu.ox.ac.uk
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Funder(s) |
British Heart Foundation
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Sponsor(s) |
University of Oxford
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