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| NB: The information displayed below does not replace the protocol. The latest protocol version should always be consulted before making clinical decisions. |
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DARE
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Drug-Induced Arrhythmia Risk Evaluation (DARE) Study
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Topic
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PCRN
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Portfolio Eligibility
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Funded by UKCRC partner
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ISRCTN
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EudraCT
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MREC N° |
02/2/73
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UKCRN ID |
2608
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WHO ID
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Study Type |
Both
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Design Type |
Screening, Genetic epidemiology
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Disease(s) |
All Diseases
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Phase |
N/A
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Current Status
| Closed - in follow-up |
| Closure Date | 13/01/2010 |
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Sample Size
| 2500 |
| Accrual to Date |
 4% |
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Geographical Scope
| UK Multi-Centre |
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Lead Country
| England |
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Main Inclusion Criteria
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A case of ventricular proarrhythmia will be defined by the following inclusion criteria:
- documented TdP, VF, polymorphic VT or non-polymorphic VT (not associated
with QT prolongation)
and/or
- exacerbation of pre-existing ventricular arrhythmias defined as either:
- a new documented ventricular arrhythmia (for example, new polymorphic VT)
- conversion of unsustained ventricular arrhythmias to sustained
and/or
- severe prolongation of the corrected QT interval >= 500ms
- moderate prolongation of the corrected QT interval
(>= 450ms [male patient] or (>= 470ms [female patient]) and a clinical history of presyncope or syncope
and
- diagnosed as secondary to therapeutic drug administration or overdosage
- age - 16 years old if included in the genetics project
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Main Exclusion Criteria
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<16 years old
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Chief Investigator(s)
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| Prof A J Camm |
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Further details, please contact
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Dr Vanessa Marshall
Drug Safety Research Unit
Bursledon Hall
Blundell Lane
Bursledon
Bursledon
Southampton
Hampshire
SO31 1AA
UNITED KINGDOM
Tel: 01275 857864
vanessa.marshall@dsru.org
| Mrs Pauline Telfer
Drug Safety Research Unit
Bursledon Hall
Blundell Lane
Bursledon
Bursledon
Southampton
Hampshire
SO31 1AA
UNITED KINGDOM
pauline.telfer@dsru.org
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Funder(s) |
British Heart Foundation
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Sponsor(s) |
St George's, University of London
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