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Perhexiline in HFpEF

Randomised double blind controlled trial of Perhexiline in heart failure with preserved ejection fraction syndrome

Specialty
Cardiovascular
Portfolio Eligibility
Automatically eligible
ISRCTN 25678870
EudraCT 2006-001109-28
MREC N° 08/H1207/84
UKCRN ID 7196
WHO ID
Research Summary
We are investigating the effect of perhexiline on patients with heart failure and preserved ejection fraction. Heart failure is a condtion that is defined by the heart's impaired energetic status. We hypothesis that by improving the heart's energetic staus with the metabolic modulating drug perhexiline, we will improve the patients exercise capacity. This improvement in exercise capacity will be due to improved cardiac energetics and improved diastolic function.
Study Type Interventional
Design Type Treatment
Disease(s) Heart Failure
Phase III
Current Status Closed - follow-up complete
Closure Date 11/30/2013
Global Sample Size 70
Global Recruitment to Date
102%
Geographical Scope UK Multi-Centre
Lead Country Scotland (also active in England)
Health care professionals can obtain a copy of the protocol by clicking here
Main Inclusion Criteria
1) heart failure normal ejection fraction diagnosed by signs or symptoms of heart failure and limitation on metabolic exercise testing.
Main Exclusion Criteria
1) renal or liver impairment
2) atrial fibrillation
3) contraindication to MRI
4) contraindication to perhexiline
Chief Investigator(s)
Prof Michael Frenneaux
Further details, please contact
Dr Roger Beadle

University of Birmingham
Department of Cardiovascular Medicine
Medical School

Edgbaston
Birmingham
West Midlands
B15 2TT
UNITED KINGDOM

Tel: 0121 4158825
rogerbeadle@hotmail.com
Dr SATNAM SINGH

University of Aberdeen
Department of Cardiology
Level 3
Bolwarth Building
Forester Hill
Aberdeen
AB25 2ZD
UNITED KINGDOM

Tel: 07932782159
s.singh@abdn.ac.uk
Funder(s) British Heart Foundation (BHF)
Sponsor(s) University of Aberdeen
NHS Grampian




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