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| | A foundation for the oral microbiome and metagenome - A foundation for the oral microbiome and metagenome | Open | Observational | No |
| | A study of Maternal Diabetes and Oral Clefts in Tayside using record linkage. - study of Maternal Diabetes and Oral Clefts in Tayside using record linkage. HIC Study. | Closed | Observational | N/A |
| | Analysis of Neutrophil Response in Chronic Periodontitis - Analysis of Neutrophil Response in Chronic Periodontitis (including the project entitled 'pro-inflammatory cytokine production by neutrophils in periodontitis patients'). | Open | Observational | No |
| | Analysis of the Saliva Proteome in periodontal health/disease - Analysis of the Saliva Proteome for Diagnostic Markers of Gingivitis and Periodontitis using FT-ICR-MS/MS. | Closed | Observational | N/A |
| 30662154 | ARTCARE - Atraumatic Restorative Treatment for Caries in the Elderly - A Pilot Study to Assess a Novel Approach for the Prevention of Root Caries | Open | Interventional | No |
| | Barriers and Facilitators of Oral Health - Barriers and Facilitators of Oral Health Behaviours Perceived by Patients, Dental Providers and Stakeholders in Outer North East London, UK: A Qualitative Study | Closed | Observational | N/A |
| | Changes in saliva composition in dry mouth patients - Changes in saliva composition in dry mouth patients | Open | Observational | Yes, within lead country only |
| 79884739 | Chewing gum and orthodontic pain - Chewing gum and orthodontic pain | Closed | Interventional and Observational | N/A |
| | Collecting saliva and bacteria to better understand tooth decay - Unravelling the relationship between the host response and the development of oral biofilms. | Closed | Observational | N/A |
| | Comparison of dental plaque salivary microflora composition and salivary parameters between caries - Comparison of dental plaque salivary microflora composition and salivary parameters between caries free and caries prone subjects | Closed | Interventional | N/A |
| | Culture of stem cells from human oral & dental tissues - Development of technique to assist with culture of stem cells from oral mucosa & dental pulp | Closed | Observational | N/A |
| | DAHANCA 21 - Hyperbaric oxygen treatment of mandibular osteoradionecrosis. A randomized clinical study | In Set-Up Pending NHS Permission | Interventional | Yes, within and outside lead country |
| | Dentine Remin Study - Using Nanoparticles as Part of a Remineralising Strategy for Dentine Affected by Caries or Acid Erosion | Open | Observational | No |
| | Detecting oral lesions by impedance spectroscopy- a feasibility study - A study to determine the feasibility of using electrical impedance spectroscopy to detect oral lesions | Closed | Interventional | N/A |
| | Development of a Nano-biosensor to Monitor Periodontal Inflammation - Development of a Nano-biosensor to Monitor Periodontal Inflammation | Open | Observational | No |
| | Diabetes and oral health (Version 1) - An exploration of the knowledge and attitudes regarding the links between diabetes and gum disease of those involved in the management of the diabetic patient. | Closed | Observational | N/A |
| | Diagnostic Test Accuracy - An Evaluation of an eReferral Management & Triage System for Minor Oral Surgery Referrals from Primary Care Dentists: Diagnostic Test Accuracy | In Set-Up Pending NHS Permission | Observational | No |
| | Dielectrophoresis in oral cancer - Dielectrophoresis as a prognostic tool for potentially malignant and malignant disease of the mouth | Closed | Interventional | N/A |
| | Diet, HPV and Oral Health - Methyl Donor Status and Oral HPV Infection in Young Adults: Importance to Oropharyngeal Cancer | Open | Observational | No |
| 57210949 | DRN149 (DDP) - Eliminating periodontal infection in patients with type 2 diabetes. | Closed | Interventional and Observational | N/A |
| 83229304 | DRN211 (Periodontitis and Type 2 Diabetes Mellitus) - Treatment of Periodontitis and metabolic control in patients with Type 2 Diabetes Mellitus | Closed | Interventional | N/A |
| | Effect of dietary supplementation on chronic periodontitis patients - The effect of daily dietary intake of dried juice concentrates of fruit, vegetables and berries(Juice Plus+) upon periodontal outcomes in chronic periodontitis | Open | Interventional | No |
| | Effect of P11-4 in patients with carious lesions - Effect of self assembling peptides P11-4 in patients with class 5 caries lesions: A mono-centre, uncontrolled, pilot study | Closed | Observational | N/A |
| | Effects of Risk Communication on Adherence with Periodontal Treatment - The Effects of Providing Individualised Periodontal Disease Risk Information on Adherence with Periodontal Treatment | Open | Interventional | No |
| | Efficacy and Cost-effectiveness of Screening by DCPs - Efficacy and Cost-effectiveness of Screening for Common Oral Diseases in a General Dental Practice Environment | In Set-Up Pending NHS Permission | Interventional | Yes, within lead country only |
| | Evidence based management of COFP - Development and evaluation of an evidence based intervention for chronic orofacial pain | Closed | Interventional | N/A |
| 55278026 | Face2face - An analysis of the effect of photographic intervention on medical dialogue within pain consultations. An exploration of photographic portraiture with patients and clinicians from oral and dental medicine | Closed | Interventional and Observational | N/A |
| | FiCTION Feasibility Study - Filling Children's Teeth: Indicated or Not? | Closed | Observational | N/A |
| 77044005 | FiCTION Pilot Rehearsal Trial - Filling Children’s Teeth: Indicated or Not? Pilot Rehearsal Trial | Closed | Interventional | N/A |
| | FiCTION Trial - FiCTION - Filling Children's Teeth: Indicated or Not? | Open | Observational | No |
| 25601281 | Genetic influence on pain in man - Genetic and psychometric role in post surgical acute pain using ASL/regional cerebral blood (rCBF) flow | Open | Interventional and Observational | -unknown- |
| 29710460 | HAP - Are microimplants as effective at providing orthodontic anchorage as conventional methods | Open | Interventional | Yes, within lead country only |
| 71267356 | Head and Neck Cancer: molecular, cellular and immunological mechanisms - Investigation of the molecular and genetic mechanisms promoting oral cancer development and progression | Open | Observational | Yes, within and outside lead country |
| 39634732 | HOPON - HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of the Irradiated Mandible | Open | Interventional | Yes, within lead country only |
| | IMPROVDENT:Improving Dentures for Patient Benefit - IMPROVDENT:Improving Dentures for Patient Benefit
A cross over randomised clinical trial comparing impression materials for complete dentures | Closed | Interventional | N/A |
| | Improving care and support for people with progressive illness - Improving care and support for people with progressive illness | Closed | Observational | N/A |
| | Improving Quality in Healthcare: A Case Study in Dental Primary Care in Scotland. - Improving Quality in Healthcare: A Case Study in Dental Primary Care in Scotland. | Open | Observational | No |
| | In vitro properties of periodontal stem cells - In vitro properties of periodontally derived mesenchymal stem cells | Open | Observational | No |
| | INCENTIVE: Improving the Organisation & Delivery of Dental Health Care - INCENTIVE: Improving the organisation and delivery of dental health care to patients - innovation in commissioning and delivery of primary dental care service delivery and organisation | Closed | Observational | N/A |
| | Inflammatory mediators in oral disease - Investigation of the role of inflammatory mediators in periodontal and periradicular inflammatory disease pathogenesis | Open | Observational | No |
| 95933794 | INTERVAL Dental Recalls Trial - Full Trial Follow-on - INTERVAL Dental Recalls Trial (Investigation of NICE Technologies for Enabling-Risk-Variable-Adjusted-Length Dental Recall Trial) - Full Trial Follow-ON | Open | Interventional | Yes, within and outside lead country |
| | INTERVAL Dental Recalls Trial. Feasibility Study - INTERVAL Dental Recalls Trial [Investigation of NICE Technologies for Enabling Risk-Variable-Adjusted-Length Dental Recall Trial] Feasibility Study | Closed | Interventional | N/A |
| 56465715 | IQuaD - Improving the Quality of Dentistry (IQuaD): A multicentre randomised controlled trial comparing oral hygiene advice and periodontal instrumentation for the prevention and management of periodontal disease in dentate adults attending dental primary care. | Open | Interventional | Yes, within and outside lead country |
| 33042138 | IVIG in the treatment of refractory trigeminal neuralgia - Low dose intravenous immunoglobulin or 0.9 sodium chloride in the treatment of primary trigeminal neuralgia refractory to Carbamazepine. A randomised double blind parrallel placebo controlled multicentre trial in an outpatient setting | Closed | Interventional | N/A |
| 58887461 | LEONIDAS-1 - Long-term effectiveness of a novel intra-oral electro-stimulator for the treatment of dry mouth in patients with Sjogren's syndrome: a feasibility study | Open | Interventional | No |
| 03712770 | Lugol's Iodine in Head and Neck Cancer Surgery - A multi-centre, randomised controlled trial assessing the effectiveness of Lugol’s Iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in-situ at mucosal resection margin of oral and oropharyngeal squamous cell carcinoma. | Open | Interventional | Yes, within and outside lead country |
| | Microbiota and host immune response in pathogenesis of oral diseases - Characterisation of oral bacterial and fungal populations and host immune response in patients with periodontal diseases, candidal mucosal infection and idiopathic recurrent aphtous stomatitis. | Open | Interventional | No |
| | Molecular Genetic Investigations of Amelogenesis Imperfecta - Understanding mammalian biomineralisation in health and disease via a molecular dissection of the mechanisms underpinning Amelogenesis Imperfecta | Open | Observational | Yes, within lead country only |
| | Monitoring of Oral Cancer Patients Using Novel Lab-On-A-Chip Ensembles - Monitoring of Oral Cancer Patients Using Novel Lab-On-A-Chip Ensembles | Closed | Interventional | N/A |
| | NESSTAC - North of England and Scotland Study of Tonsillectomy and Adenotonsillectomy in Children | Closed | Interventional and Observational | N/A |
| | Next Generation OCT resources - Next Generation components and systems for biomedical imaging | In Set-Up NHS Permission Received | Observational | No |
| | Obesity intervention delivered by dental teams - Preventing obesity in young people attending primary dental care settings: an exploratory randomised controlled trial | Open | not specified | Yes, within lead country only |
| | Ocular and Oral Complications of Haemopoietic Stem Cell Transplant - Characterisation of the Acute and Chronic Ocular and Oral Complications of Haemopoietic Stem Cell Transplant | Open | Observational | No |
| | Odontogenesis - Odontogenesis: a paradigm for mammalian biomineralisation and the role of extracellular matrix in the control of crystal deposition and growth | Withdrawn During Setup | Observational | No |
| 77607163 | Oral vs intravenous paracetamol for wisdom tooth extractions - A comparison of pre medication with oral paracetamol versus intravenous paracetamol given at time of induction for postoperative analgesia following wisdom tooth extraction | Closed | Interventional | N/A |
| | Outcomes of Periodontal Therapy in Rheumatoid Arthritis (OPERA) - Outcomes of Periodontal Therapy in Rheumatoid Arthritis (OPERA) | Open | Interventional | No |
| | PANDORA - Point-of-care Analysis by Non-invasive Dielectrophoresis for ORAl cancer diagnosis | In Set-Up Pending NHS Permission | Interventional | No |
| | Periodontitis and type 1 diabetes and smoking - An investigation of the prevalence of chronic periodontitis and other oral complications in non smoking patients with type 1 diabetes mellitus. | Closed | Observational | N/A |
| | Plaque Reduction by Polyols - A double blind crossover study to evaluate the plaque inhibitory effects of various polyols, in sugar-free chewing gum during various stages of plaque regrowth | Closed | Interventional | N/A |
| | Preparatory information for children undergoing general anaesthesia - Improving access to preparatory information for children undergoing general anaesthesia for surgical dental procedures and their families | Open | Interventional | No |
| | Prevention and Management of Dental Caries in General Practice - Understanding the systems, organisational and patient barriers and facilitators to quality improvement in primary dental care | Closed | Observational | N/A |
| | Prototype Sensor for Periodontal Disease Monitoring - Prototype Sensor for Periodontal Disease Monitoring | Closed | Observational | N/A |
| | Pulp treatment in non-vital primary molars - A pilot study to compare clinical and radiographic success of a non-root instrumentation non-vital pulpotomy and a traditional pulpectomy | Withdrawn During Setup | Interventional | No |
| | Quality of Life in Hypodontia Patients - A Multicentre Study to Assess Quality of Life in Patients with Developmentally Absent Teeth (Hypodontia) using a Condition Specific Instrument | Open | Observational | No |
| | RCT of lower denture impression techniques - RCT of lower denture impression techniques | Closed | Interventional | N/A |
| | Saliva biomarkers for diagnosis of periodontal disease - A study evaluating (selected) saliva biomarkers to validate their predictive capability in diagnosing clinical periodontal disease | Closed | Observational | N/A |
| | SALIVA NITRITE AND GASTRO-OESOPHAGEAL REFLUX - Effect of nitrite in saliva on gastro-oesophageal reflux | Closed | Interventional | N/A |
| 17029222 | Seal or Varnish? - Seal or Varnish? A randomised trial to determine the relative cost and effectiveness of pit and fissure sealants and fluoride varnish in preventing dental decay | Closed | Interventional | N/A |
| 65018995 | SEND - The role of selective neck dissection in patients with early oral squamous cell carcinoma (1-3cm primary size) and no clinical evidence of lymph node metastases in the neck (N0) | Open | Interventional | Yes, within and outside lead country |
| | SIXES - SIXES Dental Trial
Should I eXtract Every Six? | Suspended | Interventional | -unknown- |
| | SOHIPP - The Scottish Oral Health Improvement Prison Programme (SOHIPP): Developing, implementing and evaluating an oral health preventive programme for prison populations in Scotland: A survey of prisoners' oral health and a qualitative study of prisoners' oral health concerns. | Closed | Observational | N/A |
| | Technical Efficiency of Using DCPs - Determining the Optimal Model for Role-substitution in NHS Dental Services in England and Northern Ireland | In Set-Up Pending NHS Permission | Observational | Yes, within lead country only |
| | Teeth and Dentist: What Do You Think? - Development of a Child-centred Caries Specific Measure of Oral Health Related Quality of Life | Open | Observational | No |
| | The DEEP Study - The DEEP Study: Developing Effective and Efficient care Pathways for patients with chronic pain | Open | Observational | No |
| | The influence of denture microbiota on oral and systemic disease - The influence of denture microbiota on oral and systemic disease | In Set-Up Pending NHS Permission | Observational | No |
| 24437812 | The LEONIDAS2 study - Long-term Evaluation of the effectiveness Of a Novel Intra-oral electro-stimulator for the treatment of raDiotherapy-ASsociated dry mouth (The LEONIDAS-2 study) | Open | Interventional | Yes, within lead country only |
| | The Molecular Basis of Ocular Surface Disease - The Molecular Basis of Ocular Surface Disease (MBOSD) | Open | Observational | No |
| | Timing of Primary Surgery for Cleft Palate - Timing of Primary Surgery for Cleft Palate (TOPS) v1.1 | Open | Interventional | No |
| | TOPS - A randomised preference trial of medical versus surgical termination of pregnancies less than 14 weeks' gestation (TOPS) | Closed | Interventional and Observational | N/A |
| | X-ray microtomography study of carious teeth and comparison of its removal by various techniques - X-ray microtomography study of carious teeth and comparison of its removal by various techniques | Closed | Interventional | N/A |