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NB: The information displayed below does not replace the protocol. The latest protocol version should always be consulted before making clinical decisions.
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A study on emotional processing in depressed and healthy adolescents
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Investigating the effect of the antidepressant fluoxetine on emotional processing in young people with depression - a double-blind, placebo-controlled design fMRI study
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Topic
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Mental Health
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Portfolio Eligibility
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Automatically eligible
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ISRCTN
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EudraCT
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MREC N°
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12/SC/0030
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UKCRN ID
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12388
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WHO ID
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Study Type
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Interventional
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Design Type
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Treatment
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Disease(s)
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Depression
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Phase
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N/A
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Current Status
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Open
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Closure Date
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4/25/2014
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Global Sample Size
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54
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Global Recruitment to Date
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 42% |
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Geographical Scope
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Single Centre
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Lead Country
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England
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Open to new sites
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No
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Main Inclusion Criteria
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Patient group:
• Current episode of depression with or without co-morbid anxiety and in need of medication (as assessed by the Adolescent Psychiatrist);
• Participant and parent/legal guardian (for adolescents younger than 16) are willing and able to give informed consent for participation in the study;
• Male or female, aged 13−18 years;
• Right-handedness;
• Sufficiently fluent in English to understand the task and instructions.
Healthy control group:
• Participant and parent/legal guardian (for adolescents younger than 16) are willing and able to give informed consent for participation in the study;
• Male or female, aged 13−18 years;
• Right-handedness;
• Currently healthy;
• Sufficiently fluent in English to understand the task and instructions
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Main Exclusion Criteria
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Patient group:
• Current or past psychosis or mania;
• Current substance misuse;
• Psychotropic medication usage within the past 6 weeks;
• Contraindication to fMRI (e.g. braces, metal in body, claustrophobia, pregnancy, etc);
• Risk of waiting 3 to 5 days before the initiation of medication assessed as posing serious risk (as assessed by the Adolescent Psychiatrist).
Healthy control group:
• Current or past history of any psychiatric disorder (e.g., depression, anxiety);
• Current substance misuse;
• Psychotropic medication usage within the past 6 weeks;
• Contraindication to fMRI (e.g. braces, metal in body, claustrophobia, pregnancy, etc);
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Chief Investigator(s)
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| Dr Liliana Capitao |
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Further details, please contact
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Dr Liliana Capitao
Warneford Hospital
University Department of Psychiatry
Warneford Lane
Headington
Oxford
Oxfordshire
OX3 7JX
UNITED KINGDOM
Tel: 01865223622
liliana.capitao@psych.ox.ac.uk
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| Funder(s) |
Medical Research Council (MRC)
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| Sponsor(s) |
University of Oxford
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