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A study on emotional processing in depressed and healthy adolescents

Investigating the effect of the antidepressant fluoxetine on emotional processing in young people with depression - a double-blind, placebo-controlled design fMRI study

Specialty
MentalHealth
Portfolio Eligibility
Automatically eligible
ISRCTN
EudraCT
MREC N° 12/SC/0030
UKCRN ID 12388
WHO ID
Research Summary
Study Type Interventional
Design Type Treatment
Disease(s) Depression
Phase N/A
Current Status Open
Closure Date 5/31/2015
Global Sample Size 54
Global Recruitment to Date
83%
Geographical Scope Single Centre
Lead Country England
Open to new sites No
Main Inclusion Criteria
Patient group:
• Current episode of depression with or without co-morbid anxiety and in need of medication (as assessed by the Adolescent Psychiatrist);
• Participant and parent/legal guardian (for adolescents younger than 16) are willing and able to give informed consent for participation in the study;
• Male or female, aged 13−18 years;
• Right-handedness;
• Sufficiently fluent in English to understand the task and instructions.

Healthy control group:
• Participant and parent/legal guardian (for adolescents younger than 16) are willing and able to give informed consent for participation in the study;
• Male or female, aged 13−18 years;
• Right-handedness;
• Currently healthy;
• Sufficiently fluent in English to understand the task and instructions
Main Exclusion Criteria
Patient group:
• Current or past psychosis or mania;
• Current substance misuse;
• Psychotropic medication usage within the past 6 weeks;
• Contraindication to fMRI (e.g. braces, metal in body, claustrophobia, pregnancy, etc);
• Risk of waiting 3 to 5 days before the initiation of medication assessed as posing serious risk (as assessed by the Adolescent Psychiatrist).

Healthy control group:
• Current or past history of any psychiatric disorder (e.g., depression, anxiety);
• Current substance misuse;
• Psychotropic medication usage within the past 6 weeks;
• Contraindication to fMRI (e.g. braces, metal in body, claustrophobia, pregnancy, etc);
Chief Investigator(s)
Dr Liliana Capitao
Further details, please contact
Dr Liliana Capitao

Warneford Hospital
University Department of Psychiatry
Warneford Lane
Headington
Oxford
Oxfordshire
OX3 7JX
UNITED KINGDOM

Tel: 01865223622
liliana.capitao@psych.ox.ac.uk
Funder(s) Medical Research Council (MRC)
Sponsor(s) University of Oxford




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